Современные подходы к лечению цитомегаловирусной инфекции у онкогематологических больных
Аннотация
Проблема цитомегаловирусной (ЦМВ) инфекции является чрезвычайно серьезной и актуальной у иммунокомпрометированных пациентов. Препаратом, рутинно используемым для контроля ЦМВ-инфекции в данной когорте пациентов, является ганцикловир. К сожалению, такие проблемы, как миелотоксичность и развитие лекарственной резистентности, нередко ограничивают возможность его применения. Хорошей альтернативой является валганцикловир, эффективность которого подтверждена в клинических исследованиях. Проблема контроля ЦМВ-инфекции не является решенной, даже несмотря на внедрение в практику высокоэффективных методов ранней диагностики и упреждающей терапии. Использование иммуноаблативных препаратов (таких как алемтузумаб или антитимоцитарный глобулин), а также трансплантация гемопоэтических стволовых клеток от альтернативных доноров являются факторами высокого риска развития жизнеугрожающих висцеральных ЦМВ-ассоциированных осложнений. Новые методы контроля ЦМВ активно исследуются в настоящее время. В частности, одним из перспективных направлений является культивирование и клиническое использование ЦМВ-специфических Т-лимфоцитов.
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Для цитирования:
Балашов Д.Н. Современные подходы к лечению цитомегаловирусной инфекции у онкогематологических больных. Онкогематология. 2013;8(1):46-51. https://doi.org/10.17650/1818-8346-2013-8-1-46-51
For citation:
Balashov D.N. Trends in the treatment of cytomegalovirus infection in oncohematological patients. Oncohematology. 2013;8(1):46-51. (In Russ.) https://doi.org/10.17650/1818-8346-2013-8-1-46-51
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