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Chronic myelogenous leukemia: molecular monitoring in clinical practice
- Authors: Ryabchikova N.R.1, Minniakhmetov I.R.2, Safuanova G.S.1, Islamgulov D.V.2, Karunas A.S.2, Khusnutdinova E.E.2
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Affiliations:
- Bashkortostan State Medical University, Ministry of Health of Russia
- Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences
- Issue: Vol 8, No 1 (2013)
- Pages: 7-16
- Section: HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE
- Published: 22.02.2013
- URL: https://oncohematology.abvpress.ru/ongm/article/view/39
- DOI: https://doi.org/10.17650/1818-8346-2013-8-1-7-16
- ID: 39
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Abstract
Use of tyrosine kinase inhibitor imatinib has led to significant progress in chronic myeloid leukemia (CML) treatment. To date, genetic monitoring is a mandatory attribute of therapy with tyrosine kinase inhibitors. The purpose of this study was to access the imatinib therapy efficacy in CML patients using complete molecular genetic monitoring by standard cytogenetics, realtime polymerase chain reaction and mutational analysis. Correlation between cytogenetic and molecular response was shown. Heterogeneity of molecular response in each patient group was revealed by expression of BCR-ABL. Kinase domain mutations were detected in 32 % of CML patients resistant to imatinib.
About the authors
N. R. Ryabchikova
Bashkortostan State Medical University, Ministry of Health of RussiaRussian Federation
I. R. Minniakhmetov
Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of SciencesRussian Federation
G. Sh. Safuanova
Bashkortostan State Medical University, Ministry of Health of Russia
Author for correspondence.
Email: safuanova@bk.ru
Russian Federation
D. V. Islamgulov
Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of SciencesRussian Federation
A. S. Karunas
Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of SciencesRussian Federation
E. E. Khusnutdinova
Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of SciencesRussian Federation
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