Preview

Oncohematology

Advanced search

Extramedular lesions of a small intestinum in acute myeloid leukemia: case report and literature review

https://doi.org/10.17650/1818-8346-2019-14-2-41-47

Abstract

Currently, the diagnosis of acute myeloid lekemia is based on the standards of morphological studies and immunophenotyping of the bone marrow. The manifestation of the disease can be accompanied by extramedullary lesions, which are difficult to verify. The article presents a case of diagnosis of acute myeloid lekemia in an elderly w oman, occurring with a leukemic lesion of the small in - testine. Morphological studies and immunophenotyping of small intestine biopsy revealed acute myeloid lekemia blast tumor cells. Difficulties of examination in such cases lead to late revealing of leukemic infiltrates of rare localization and significantly worsen the prognosis. 

About the Authors

I. A. Dokshina
Kirov Research Institute of Haematology and Blood Transfusion under the Federal Medicobiological Agency
Russian Federation
72 Krasnoarmeyskaya St., Kirov 610027, Russia


A. V. Lyanguzov
Kirov Research Institute of Haematology and Blood Transfusion under the Federal Medicobiological Agency
Russian Federation
72 Krasnoarmeyskaya St., Kirov 610027, Russia


S. V. Ignatyev
Kirov Research Institute of Haematology and Blood Transfusion under the Federal Medicobiological Agency
Russian Federation
72 Krasnoarmeyskaya St., Kirov 610027, Russia


O. Yu. Sergunina
Kirov Research Institute of Haematology and Blood Transfusion under the Federal Medicobiological Agency
Russian Federation
72 Krasnoarmeyskaya St., Kirov 610027, Russia


S. L. Kalinina
Kirov Research Institute of Haematology and Blood Transfusion under the Federal Medicobiological Agency
Russian Federation
72 Krasnoarmeyskaya St., Kirov 610027, Russia


E. S. Prokopyev
Kirov Research Institute of Haematology and Blood Transfusion under the Federal Medicobiological Agency
Russian Federation
72 Krasnoarmeyskaya St., Kirov 610027, Russia


D. A. Dyakonov
Kirov Research Institute of Haematology and Blood Transfusion under the Federal Medicobiological Agency
Russian Federation
72 Krasnoarmeyskaya St., Kirov 610027, Russia


References

1. Grove C.S., Vassiliou G.S. Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer? Dis Model Mech 2014;7(8):941–51. DOI: 10.1242/dmm.015974.

2. Cho-Vega J.H., Medeiros L.J., Prieto V.G. et al. Leukemia cutis. Am J Clin Pathol 2008;129(1):130–42. DOI: 10.1309/WYACYWF6NGM3WBRT.

3. Kravtsova E.N., Shchetinina O.V. Myeloid sarcoma in the practice of otorhinolaryngologist. Rossiyskaya otorinolaringologiya = Russian Otorhinolaryngology 2017;(6):135–9. (In Russ.).

4. Byrd J.C., Weiss R.B., Arthur D.C. et al. Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21) (q22;q22): results from Cancer and Leukemia Group B 8461. J Clin Oncol 1997;15(2):466–75. DOI: 10.1200/JCO.1997.15.2.466.

5. Faaij C.M., Willemze A.J., Révész T. et al. Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: differential roles for CCR2, CCR5, CXCR4 and CXCR7. Pediatr Blood Cancer 2010;55(2):344–8. DOI: 10.1002/pbc.22500.

6. Pileri S.A., Ascani S., Cox M.C. et al. Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia 2007;21(2):340–50. DOI: 10.1038/sj.leu.2404491.

7. Choi M., Jeon Y. K., Sun C.H. et al. RTK-RAS pathway mutation is enriched in myeloid sarcoma. Blood Cancer J 2018;8(5):43. DOI: 10.1038/s41408-018-0083-6.

8. Arber D.A., Orazi A., Hasserjian R. et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016;127(20):2391–405. DOI: 10.1182/blood-2016-03-643544.

9. Troitskaya V.V., Parovichnikova E.N., Savchenko V.G. The protocol for the differential treatment of acute myeloid leukemia in patients over 60 years old. In: Algorithms for diagnosis and protocol for the treatment of diseases of the blood system. Ed.: V.G. Savchenko. Vol. 1. Moscow: Praktika, 2019. Pp. 529–569. (In Russ.).

10. Klimashevskiy V.F., Morozova E.V., Shashkova N.G. et al. Myeloid sarcoma of the cervix as a manifestation of the recurrence of acute myeloblastic leukemia. Voprosy onkologii = Problems in Oncology 2006;(1):102–4. (In Russ.).

11. Breccia M., Mandelli F., Petti M.C. et al. Clinico-pathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution. Leuk Res 2004;28(11):1165–9. DOI: 10.1016/j.leukres.2004.01.022.

12. Valiev T.T., Kovrigina A.M., Panferova T.R. et al. A Case report of myeloid sarcoma in a child. Clinicheskaya onkogematologiya = Clinical Oncohematology 2017;10(2):218–26. (In Russ.). DOI: 10.21320/2500-2139-2017-10-2-218-226.

13. Girelli C.M., Carsenzuola V., Latargia M. et al. Small-bowel myeloid sarcoma: Report of a case with atypical presentation. Int J Surg Case Rep 2014;5(9):613–6. DOI: 10.1016/j.ijscr.2014.07.002.

14. Choi E.K., Ha H.K., Park S.H. et al. Granulocytic sarcoma of bowel: CT findings. Radiology 2007;243(3):752–9. DOI: 10.7860/JCDR/2014/9112.4578.

15. Ignatyev S.V., Lyanguzov A.V., Dokshina I.A. et al. Analysing clinical cases of antibioticassociated colitis in a patient with hodgkin’s lymphoma. Vyatskiy meditsinskiy vestnik = Medical Newsletter of Vyatka 2018;1(57):67–70. (In Russ.).

16. Hagen P.A., Singh C., Hart M., Blaes A.H. Differential diagnosis of isolated myeloid sarcoma: a case report and review of the literature. Hematol Rep 2015;7(2):5709. DOI: 10.4081/hr.2015.5709.

17. Le Beau M.M., Larson R.A., Bitter M.A. et al. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. N Engl J Med 1983;309:630–6. DOI: 10.1056/NEJM198309153091103.

18. Russell S.J., Giles F.J., Thompson D.S. et al. Granulocytic sarcoma of the small intestine preceding acute myelomonocytic leukemia with abnormal eosinophils and inv (16). Cancer Genet Cytogenet 1988;35:231–5.

19. Morel F., Herry A., Le Bris M.J. et al. Isolated granulocytic sarcoma followed by acute myelogenous leukemia type FAB-M2 associated with inversion 16 and trisomies 9 and 22. Leukemia 2002;16(12):2458–9. DOI: 10.1038/sj.leu.2402593.

20. Alvarez P., Navascués C.A., Ordieres C. et al. Granulocytic sarcoma of the small bowel, greater omentum and peritoneum associated with a CBFβ/MYH11 fusion and inv(16) (p13q22): a case report. Int Arch Med 2011;4(1):3. DOI: 10.1186/1755-7682-4-3.

21. Gajendra S., Gogia A., Das P. et al. Acute myeloid leukemia presenting as “Bowel upset”: a case report. J Clin Diagnost Res 2014;8(7):9–10. DOI: 10.7860/JCDR/2014/9112.4578.


Review

For citations:


Dokshina I.A., Lyanguzov A.V., Ignatyev S.V., Sergunina O.Yu., Kalinina S.L., Prokopyev E.S., Dyakonov D.A. Extramedular lesions of a small intestinum in acute myeloid leukemia: case report and literature review. Oncohematology. 2019;14(2):41-47. (In Russ.) https://doi.org/10.17650/1818-8346-2019-14-2-41-47

Views: 10945


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1818-8346 (Print)
ISSN 2413-4023 (Online)