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КЛИНИЧЕСКАЯ ХАРАКТЕРИСТИКА И РЕЗУЛЬТАТЫ ТЕРАПИИ РЕЦИДИВОВ/РЕФРАКТЕРНЫХ ФОРМ НЕХОДЖКИНСКИХ ЛИМФОМ У ДЕТЕЙ: ОБЗОР ЛИТЕРАТУРЫ И АНАЛИЗ СОБСТВЕННЫХ ДАННЫХ

https://doi.org/10.17650/1818-8346-2018-13-2-21-31

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Аннотация

Несмотря на разработку и активное использование современных высокоэффективных протоколов лечения неходжкинских лимфом (НХЛ) у детей, результаты терапии рецидивов и рефрактерных форм остаются неудовлетворительными. В настоящей статье приведен мировой и собственный опыт лечения рецидивов/рефрактерных форм различных вариантов НХЛ у детей: лимфобластных лимфом из клеток-предшественников, анапластической крупноклеточной лимфомы и гетерогенной группы лимфом из зрелых В-клеток. Представлены противорецидивные схемы лечения, результаты использования неларабина, ритуксимаба, кризотиниба, брентуксимаба ведотина, трансплантации гемопоэтических стволовых клеток в лечении рецидивов и рефрактерных форм НХЛ. При анализе терапии рецидивов 27 больных с НХЛ, проходивших лечение в ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» МЗ РФ, показатель общей выживаемости составил 29,1 ± 7,9 % (медиана наблюдения 56,3 ± 14,4 мес). Попытки терапии первично рефрактерного течения НХЛ оказались неудачными. Собственные и литературные данные заставляют проводить дальнейший поиск терапевтических решений, направленных на повышение результатов терапии рецидивов и рефрактерных форм НХЛ.

Об авторе

Т. Т. Валиев
ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России, НИИ детской онкологии и гематологии
Россия

Тимур Теймуразович Валиев

115478 Москва, Каширское шоссе, 23



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Для цитирования:


Валиев Т.Т. КЛИНИЧЕСКАЯ ХАРАКТЕРИСТИКА И РЕЗУЛЬТАТЫ ТЕРАПИИ РЕЦИДИВОВ/РЕФРАКТЕРНЫХ ФОРМ НЕХОДЖКИНСКИХ ЛИМФОМ У ДЕТЕЙ: ОБЗОР ЛИТЕРАТУРЫ И АНАЛИЗ СОБСТВЕННЫХ ДАННЫХ. Онкогематология. 2018;13(2):21-31. https://doi.org/10.17650/1818-8346-2018-13-2-21-31

For citation:


Valiev T.T. CLINICAL CHARACTERISTICS AND TREATMENT RESULTS OF PEDIATRIC RELAPSED/REFRACTORY NON-HODGKIN’S LYMPHOMAS. Oncohematology. 2018;13(2):21-31. (In Russ.) https://doi.org/10.17650/1818-8346-2018-13-2-21-31

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ISSN 1818-8346 (Print)
ISSN 2413-4023 (Online)