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HETEROGENEITY OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (EGIL SUBTYPE BIV)
- Authors: Demina I.A.1, Verzhbitskaya Т.Y.2,3, Kashpor S.A.1, Baidun L.V.4, Koniuhova T.V.1, Plyasunova S.A.1, Tsaur G.А.2,3, Rusanova E.B.5, Gorchakova M.V.5, Zueva E.E.5,6, Kazakova A.N.1, Zerkalenkova E.A.1, Olshanskaya Y.V.1, Abugova Y.G.1, Fechina L.G.2,3, Miakova N.V.1, Samochatova E.V.1, Maschan А.А.1, Popov А.M.1
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Affiliations:
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
- Sverdlovsk Regional Clinical Children’s Hospital No 1
- Research Institute of Medical Cell Technologies
- Russian Children Clinical Hospital, Ministry of Health of Russia
- I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
- Ariel University
- Issue: Vol 12, No 4 (2017)
- Pages: 34-40
- Section: BASIC RESEARCH
- Published: 08.12.2017
- URL: https://oncohematology.abvpress.ru/ongm/article/view/265
- DOI: https://doi.org/10.17650/1818-8346-2017-12-4-34-40
- ID: 265
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Abstract
Introduction. Surface immunoglobulin expression is a main immunophenotypic criteria of mature subtype of B-lineage acute lymphoblastic leukemia. Although the majority of such cases represents Burkitt leukemia/lymphoma, it was shown for several times that membrane IgM could be detected in the absence of other mature lymphomas signs.
The aim of the study was to evaluate heterogeneity of childhood acute lymphoblastic leukemia (ALL) with surface IgM expression and to assess correspondence of BIV EGIL ALL subtype with Burkitt lymphoma (BL) bone marrow dissemination.
Materials and methods. Immunophenotypic, cytomorfologic and genetic data of 54 BIV-ALL cases were analyzed.
Results. Among the studied patients 39 had BL, while others belonged to B-cell precursor ALL (BCP-ALL). All BL patients and none of BCP-ALL patients carried C-MYC rearrangement while in BCP-ALL group in 8 cases and in any BL cases KMT2A rearrangements were found. None of BCP-ALL children had L3 morphology according to FAB classification.
Conclusions. B-lineage ALL with surface IgM expression is rather heterogeneous group of cases including typical BL and rare cases of BCP-ALL even with KMT2A-rearrangements. Combination of all available diagnostic technologies will allow precise split of these two different disease and select the appropriate treatment scheme.
About the authors
I. A. Demina
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationТ. Yu. Verzhbitskaya
Sverdlovsk Regional Clinical Children’s Hospital No 1; Research Institute of Medical Cell Technologies
32 Serafimy Deryabinoy St., Ekaterinburg 620149; 22a Karla Marksa St., Ekaterinburg 620026
Russian FederationS. A. Kashpor
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationL. V. Baidun
Russian Children Clinical Hospital, Ministry of Health of Russia
117 Leninskiy Prospect, Moscow, 119571
Russian FederationT. V. Koniuhova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationS. A. Plyasunova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationG. А. Tsaur
Sverdlovsk Regional Clinical Children’s Hospital No 1; Research Institute of Medical Cell Technologies
32 Serafimy Deryabinoy St., Ekaterinburg 620149; 22a Karla Marksa St., Ekaterinburg 620026
Russian FederationE. B. Rusanova
I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
6–8 L. Tolstogo St., Saint Petersburg 197022
Russian FederationM. V. Gorchakova
I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
6–8 L. Tolstogo St., Saint Petersburg 197022
Russian FederationE. E. Zueva
I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia; Ariel University
Faculty of Natural Sciences, Department of Molecular Biology ArU.
6–8 L. Tolstogo St., Saint Petersburg 197022; Ariel, 40700
IsraelA. N. Kazakova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationE. A. Zerkalenkova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationYu. V. Olshanskaya
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationYu. G. Abugova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationL. G. Fechina
Sverdlovsk Regional Clinical Children’s Hospital No 1; Research Institute of Medical Cell Technologies
32 Serafimy Deryabinoy St., Ekaterinburg 620149; 22a Karla Marksa St., Ekaterinburg 620026
Russian FederationN. V. Miakova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationE. V. Samochatova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationА. А. Maschan
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationА. M. Popov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
Author for correspondence.
Email: uralcytometry@gmail.com
1 Samory Mashela St., Moscow 117997, GSP-7
Russian FederationReferences
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