ЭФФЕКТИВНОСТЬ ВЕНЕТОКЛАКСА В ТЕРАПИИ ХРОНИЧЕСКОГО ЛИМФОЛЕЙКОЗА (ОБЗОР ЛИТЕРАТУРЫ)
Аннотация
В последние годы в терапии хронического лимфолейкоза (ХЛЛ) произошла революция, связанная с появлением новых таргетных препаратов, которые существенно улучшили результаты лечения всех групп больных ХЛЛ. При этом ингибиторы тирозинкиназы Брутона (ибрутиниб, акалабрутиниб и др.) и изоформ фосфатидилинозитол-3-киназы (иделалисиб, умбралисиб и др.) находятся на пике популярности, в то время как ингибиторам антиапоптотических белков (венетоклакс) уделяется незаслуженно мало внимания. В данном обзоре мы представляем результаты клинических исследований венетоклакса в монотерапии и комбинированных схемах при ХЛЛ. Отличительной чертой данного препарата является высокая частота достижения полных ответов и эрадикации минимальной остаточной болезни у пациентов с ХЛЛ высокого риска, а также хорошо контролируемый профиль токсичности, что делает его идеальным компонентом негенотоксичных режимов, нацеленных на полное излечение заболевания.
Об авторах
В. В. Стругов
ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России
Россия
Россия
Владимир Владимирович Стругов.
197341 Санкт-Петербург, ул. Аккуратова, 2
Е. А. Стадник
ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России
Россия
Россия
197341 Санкт-Петербург, ул. Аккуратова, 2
А. Ю. Зарицкий
ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России
Россия
Россия
197341 Санкт-Петербург, ул. Аккуратова, 2
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Рецензия
Для цитирования:
Стругов В.В., Стадник Е.А., Зарицкий А.Ю. ЭФФЕКТИВНОСТЬ ВЕНЕТОКЛАКСА В ТЕРАПИИ ХРОНИЧЕСКОГО ЛИМФОЛЕЙКОЗА (ОБЗОР ЛИТЕРАТУРЫ). Онкогематология. 2017;12(4):18-26. https://doi.org/10.17650/1818-8346-2017-12-4-18-26
For citation:
Strugov V.V., Stadnik E.A., Zaritskey A.Yu. EFFECTIVENESS OF VENETOСLAX IN THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (LITERATURE REVIEW). Oncohematology. 2017;12(4):18-26. (In Russ.) https://doi.org/10.17650/1818-8346-2017-12-4-18-26
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