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Что нам известно об истинной полицитемии (обзор литературы и собственные данные)

https://doi.org/10.17650/1818-8346-2015-10-3-28-42

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Аннотация

В статье приведены данные обзора литературы и собственного многолетнего опыта диагностики и лечения истинной полицитемии (ИП). Представлены результаты внедрения последних достижений в области изучения патогенеза, ведущим механизмом которого является активация сигнального пути JAK-STAT, в подавляющем большинстве случаев обусловленная мутацией гена JAK2, новейших разработок в диагностике и терапии ИП. Приведены материалы собственных наблюдений эпидемиологии, клинических проявлений, результатов обследования и лечения 252 больных ИП. Наиболее частыми проявлениями заболевания в момент диагностики ИП были: плетора, головная боль, головокружение, слабость, кожный зуд. Описаны диагностические критерии, прогностическая шкала риска развития тромбозов. Частота развития тромбозов в исследуемой группе больных ИП составила в целом 11,1 %, в том числе инфаркты миокарда–3,6 %, острые нарушения мозгового кровообращения–5,2 %. Частота тром- бозов статистически значимо различалась в различных прогностических группах: от 2,6 % в группе больных с низким риском тромбозов до 20,6 % в группе с высоким риском. Представлен используемый авторами персонализированный алгоритм терапии ИП. Изложены особенности применения различных методов лечения, результаты использования таргетных препаратов (ингибиторов янускиназ).

Об авторах

К. М. Абдулкадыров
ФГБУ «Российский научно-исследовательский институт гематологии и трансфузиологии Федерального медико-биологического агентства»
Россия
191024, Санкт-Петербург, ул. 2-я Советская, 16


Василий Анатольевич Шуваев
ФГБУ «Российский научно-исследовательский институт гематологии и трансфузиологии Федерального медико-биологического агентства»
Россия
191024, Санкт-Петербург, ул. 2-я Советская, 16


И. С. Мартынкевич
ФГБУ «Российский научно-исследовательский институт гематологии и трансфузиологии Федерального медико-биологического агентства»
Россия
191024, Санкт-Петербург, ул. 2-я Советская, 16


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Для цитирования:


Абдулкадыров К.М., Шуваев В.А., Мартынкевич И.С. Что нам известно об истинной полицитемии (обзор литературы и собственные данные). Онкогематология. 2015;10(3):28-42. https://doi.org/10.17650/1818-8346-2015-10-3-28-42

For citation:


Abdulkadyrov K.M., Shuvaev V.A., Martynkevich I.S. All we know about polycythemia vera: literature review and own experience. Oncohematology. 2015;10(3):28-42. (In Russ.) https://doi.org/10.17650/1818-8346-2015-10-3-28-42

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ISSN 1818-8346 (Print)
ISSN 2413-4023 (Online)