Late non-infectious lung damage in children after allogeneic hematopoietic stem cells transplantation

Hematopoietic stem cells transplantation (HSCT) technology currently allows curing a lot of malignant and non-malignant diseases in adults and children. However, HSCT is highly toxic treatment. HSCT complications include the possibility of prolonged immunodeficiency, alloand autoimmune reactions and various organs dysfunction. These conditions require careful monitoring by specialists, early diagnosis and appropriate treatment. This article discusses the clinical features, diagnosis and treatment options of such late complications as non-infectious lung disease. These conditions can lead to disability of patients. Relevance and importance of timely diagnosis of these pathological conditions, including the range of clinical tests available on a residence, with a view to effective treatment can improve the quality of life of
children with complications after HSCT. Theoretical issues are illustrated by case report.

1. Krowka M. J., Rosenow E. C. 3rd, Hoagland H. C. Pulmonary complications of bone marrow transplantation. Chest 1985;87(2):237–46.

2. Roca J., Grañeña A., Rodriguez-Roisin R. et al. Fatal airway disease in an adult with chronic graft-versus-host disease. Thorax 1982;37(1):77–8.

3. Chan C. K., Hyland R. H., Hutcheon M. A. et al. Small-airways disease in recipients of allogeneic bone marrow transplants. An analysis of 11 cases and a review of the literature. Medicine (Baltimore) 1987;66(5):327–40.

4. Palmas A., Tefferi A., Myers J. L. et al. Late-onset noninfectious pulmonary complications after allogeneic bone marrow transplantation. Br J Haematol 1998;100(4):680–7.

5. Michelson P. H., Goyal R., Kurland G. Pulmonary complications of haematopoietic cell transplantation in children. Paediatr Respir Rev 2007;8(1):46–61.

6. Duncan C. N., Buonanno M. R., Barry E. V. et al. Bronchiolitis obliterans following pediatric allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation 2008;41(11):971–5.

7. Cerveri I., Zoia M. C., Fulgoni P. et al. Late pulmonary sequelae after childhood bone marrow transplantation. Thorax 1999;54(2):131–5.

8. Uderzo C., Pillon M., Corti P. et al. Impact of cumulative anthracycline dose, preparative regimen and chronic graft versus- host disease on pulmonary and cardiac function in children 5 years after allogeneic hematopoietic stem cell transplantation: a prospective evaluation on behalf of the EBMT Pediatric Diseases and Late Effects Working Parties. Bone Marrow Transplant 2007;39(11):667–75.

9. Nishio N., Yagasaki H., Takahashi Y. et al. Late-onset non-infectious pulmonary complications following allogeneic hematopoietic stem cell transplantation in children. Bone Marrow Transplant 2009;44(5):303–8.

10. Anfessa B., Litzow M. R., Tefferi A. Bronchiolitis obliterans and other late onset-non infectious pulmonary complications in hematopoietic stem cell transplantation. Bone Marrow Transplant 2001;28(5):425–34.

11. Patriarca F., Skert C., Bonifazi F. et al. Effect on survival of the development of lateonset non-infectious pulmonary complications after stem cell transplantation. Haematologica 2006;91(9):1268–72.

12. Panoskaltsis-Mortari A., Griese M., Madtes D. K. et al. An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome. Am J Respir Crit Сare Med 2011;183(9):1262–79.

13. Soubani A. O., Uberti J. P. Bronchiolitis obliterans following haematopoietic stem cell transplantation. Eur Respir J 2007;29(5):1007–19.

14. Leiper A. D. Non-endocrine late complications of bone marrow transplantation in childhood: part I. Br J Haematol 2002;118(1):3–22.

15. Filipovich A. H., Weisdorf D., Pavletic S. et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 2005;11(12):945–56.

16. Yoshihara S., Yanik G., Cooke K. R., Mineishi S. Bronchiolitis obliterans syndrome (BOS), bronchiolitis obliterans organizing pneumonia (BOOP), and other late-onset noninfectious pulmonary complications following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2007;13(7):749–59.

17. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002;165(2):277–304.

18. Sakaida E., Nakaseko C., Harima A. et al. Late-onset noninfectious pulmonary complications after allogeneic stem cell transplantation are significantly associated with chronic graft-versus-host disease and with graft-versus-leukemia effect. Blood 2003;102(12):4236–42.

19. Faraci M., Barra S., Cohen A. et al. Very late nonfatal consequences of fractionated TBI in children undergoing bone marrow transplant. Int J Radiation Biol Phys 2005;63(5):1568–75.

20. Patriarca F., Poletti V., Costabel U. et al. Clinical presentation, outcome and risk factors of late-onset non-infectious pulmonary complications after allogeneic stem cell transplantation. Curr Stem Cell Res Ther 2009;4(2):161–7.

21. Nusair S., Breuer R., Shapira M. Y. et al. Low incidence of pulmonary complications following nonmyeloablative stem cell transplantation. Eur Respir J 2004;23(3):440–5.

22. Yoshihara S., Tateishi U., Ando T. et al. Lower incidence of Bronchiolitis obliterans in allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning compared with myeloablative conditioning. Bone Marrow Transplant 2005;35(12):1195–200.

23. Gazourian L., Rogers A. J., Ibanga R. et al. Factors associated with bronchiolitis obliterans syndrome and chronic graft- versus-host disease after allogeneic hematopoietic cell transplantation. Am J Hematol 2014;89(4):404–9.

24. Dudek A. Z., Mahaseth H., DeFor T.E., Weisdorf D. J. Brinchiolitis obliterans in chronic graft-versus-host disease: analysis of risk factors and treatment outcomes. Biol Blood Marrow Transplant 2003;9(10):657–66.

25. Barker A. F., Bergeron A., Rom W. N., Hertz M. I. Obliterative bronchiolitis. N Engl J Med 2014;370(19):1820–8.

26. Santo Tomas L. H., Loberiza F. R. Jr, Klein J. P. et al. Risk factors for bronchiolitis obliterans in allogeneic hematopoietic stem cell transplantation for leukemia. Chest 2005;128(1):153–61.

27. Ueda K., Watadani T., Maeda E. et al. Outcome and treatment of late-onset noninfectious pulmonary complications after allogeneic haematopoietic SCT. Bone Marrow Transplant 2010;45(12):1719–27.

28. Marras T. K., Chan C. K., Lipton J. H. et al. Long-term pulmonary function abnormalities and survival after allogeneic marrow transplantation. Bone Marrow Transplant 2004;33(5):509–17.

29. Freudenberger T. D., Madtes D. K., Curtis J. R. et al. Association between acute and chronic graft-versus-host disease and bronchiolitis obliterans organizing pneumonia in recipients of hematopoietic stem cell transplants. Blood 2003;102(10):3822–8.

30. Fukuda T., Hackman R. C., Guthrie K. A. et al. Risks and outcomes of idiopathic pneumonia syndrome after nonmyeloablative and conventional conditioning regimens after allogeneic hematopoietic stem cell transplantation. Blood 2003;102(8):2777–85.

31. Fullmer J. J., Fan L. L., Dishop M. K. et al. Successful treatment of bronchiolitis obliterans in a bone marrow transplant patient with tumor necrosis factor-alpha blockade. Pediatrics 2005;116(3):767–70.

32. Bergeron A., Belle A., Chevret S. et al. Combined inhaled steroids and bronchodilatators in obstructive airway disease after allogeneic stem cell transplantation. Bone Marrow Transplant 2007;39(9):547–53.

33. Ratjen F., Rjabko O., Kremens B. High- dose corticosteroid therapy for brochiolitis obliterans after bone marrow transplantation in children. Bone Marrow Transplant 2005;36(2):135–8.

34. Khalid M., Al Saghir A., Saleemi S. et al. Azithromycin in bronchiolitis obliterans complicating bone marrow transplantation: a preliminary study. Eur Respir J 2005;25(3):490–3.

35. Pathak V., Kuhn J. M., Durham C. et al. Macrolide use leads to clinical and radiological improvements in patients with cryptogenic organizing pneumonia. Ann Am Thorac Soc 2014;11(1):87–91.

36. Jaksch P., Scheed A., Keplinger M. et al. A prospective interventional study on the use of extracorporeal photopheresis in patients with bronchiolitis obliterans syndrome after lung transplantation. J Heart Lung Transplant 2012;31(9):950–7.

37. Lucid C. E., Savani B. N., Engelhardt B. G. et al. Extracorporeal photopheresis in patients with refractory bronchiolitis obliterans developing after allo- SCT. Bone Marrow Transplant 2011;46(3):426–9.

38. Guihot A., Becquemin M. H., Couderc L. J. et al. Telemetric monitoring of pulmonary function after allogeneic hematopoietic stem cell transplantation. Transplantation 2007;83(5):554–60.