Поздние неинфекционные поражения легких у детей после аллогенной транспл антации гемопоэтических стволовых клеток

Технологии трансплантации гемопоэтических стволовых клеток (ТГСК) в настоящее время позволяют излечить множество злокачественных и незлокачественных заболеваний взрослых и детей. Однако ТГСК остается высокотоксичным методом лечения, среди осложнений которого возможны длительный иммунодефицит, алло- и аутоиммунные реакции, дисфункции различных органов и систем. Эти состояния требуют тщательного наблюдения специалистами, ранней диагностики и адекватного лечения. В данной статье обсуждаются клинические особенности, диагностика и варианты терапии такой сложной группы поздних посттрансплантационных осложнений, как неинфекционные поражения легких. Эти состояния могут приводить к инвалидизации пациентов, несмотря на выздоровление от основного заболевания. Отражены актуальность и значимость своевременной диагностики данных патологических состояний, в том числе спектр исследований, доступных по месту жительства, с целью их эффективного лечения и улучшения качества жизни детей с осложнениями после ТГСК. Теоретические вопросы проиллюстрированы случаем из практики.

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