Platelets and hemostasis
https://doi.org/10.17650/1818-8346-2014-9-2-65-73
Abstract
Platelets are anuclear cell fragments playing important role in hemostasis, termination of bleeding after damage, as well as in pathological thrombus formation. The main action of platelets is the formation of aggregates, overlapping the injury. They obtained the ability to aggregate by the transition process called activation. Despite the relatively simple and definite function platelet structure is very difficult: they have almost a full set of organelles, including the endoplasmic reticulum, mitochondria and other entities. When activated platelets secrete various granules interact with plasma proteins and red blood cells and other tissues. Their activation is controlled by multiple receptors and complex signaling cascades. In this review platelet structure, mechanisms of its functioning in health and disease, diagnostic methods of platelet function and approaches to their correction were considered. Particular attention will be given to those areas of the science of platelets, which still lay hidden mysteries.
About the Authors
M. A. Panteleev
Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow;
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev,
Ministry of Health of Russia, Moscow;
Lomonosov Moscow State University, Faculty of Physics, Moscow;
Hematological Research Center, Ministry of Health of Russia, Moscow;
HemaCore Company, Moscow
Russian Federation
Russian Federation
A. N. Sveshnikova
Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow;
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev,
Ministry of Health of Russia, Moscow;
Lomonosov Moscow State University, Faculty of Physics, Moscow;
Russian Federation
Russian Federation
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Review
For citations:
Panteleev M.A., Sveshnikova A.N. Platelets and hemostasis. Oncohematology. 2014;9(2):65-73. (In Russ.) https://doi.org/10.17650/1818-8346-2014-9-2-65-73
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