Биологические свойства гемопоэтических стволовых клеток пуповинной крови
Аннотация
Обзор литературы посвящен анализу эволюции изучения пуповинной крови как источника гемопоэтических стволовых клеток для трансплантации. Поэтапно описано развитие технологий определения и выделения стволовых клеток, оценки их способности к пролиферации и дифференцировке и функциональных характеристик с помощью методов культивирования in vitro и с помощью выращивания in vivo на животных моделях. Описаны различия стволовых клеток пуповинной крови в сравнении с другими тканевыми источниками. Показана роль микроокружения для самообновления и дифференцировки стволовых клеток. Исследованы возможности моделирования биологических свойств стволовых клеток на примере использования векторной конструкции на основе вируса иммунодефицита человека 1 типа, содержащей гены Notch, для регулирования пролиферации CD133+ и CD34+ гемопоэтических стволовых клеток пуповинной крови человека.
Об авторах
С. А. Румянцев
ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии
Минздравсоцразвития России
Россия
Россия
Е. Ю. Осипова
ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии
Минздравсоцразвития России
Россия
Россия
С. Е. Ипатов
ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии
Минздравсоцразвития России
Россия
Россия
Т. В. Шаманская
ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии
Минздравсоцразвития России
Россия
Россия
О. А. Майорова
ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии
Минздравсоцразвития России
Россия
Россия
А. Г. Румянцев
ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии
Минздравсоцразвития России
Россия
Россия
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Для цитирования:
Румянцев С.А., Осипова Е.Ю., Ипатов С.Е., Шаманская Т.В., Майорова О.А., Румянцев А.Г. Биологические свойства гемопоэтических стволовых клеток пуповинной крови. Онкогематология. 2011;6(1):64-75. https://doi.org/10.17650/1818-8346-2011-6-1-64-75
For citation:
Rumiantsev S.A., Osipova E.Y., Ipatov S.E., Shamanskaya T.V., Mayorova O.A., Rumyantsev A.G. Biological properties of cord blood hematopoietic stem cells. Oncohematology. 2011;6(1):64-75. (In Russ.) https://doi.org/10.17650/1818-8346-2011-6-1-64-75
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