Acute lymphoblastic leukemia with eosinophilia: diagnostic and treatment features
https://doi.org/10.17650/1818-8346-2025-20-2-67-74
Abstract
Acute lymphoblastic leukemia (ALL) manifested by eosinophilia (>1.5 × 109/L) in peripheral blood is extremely rare, less than 1 % of all ALL cases. A characteristic feature of patients with ALL and eosinophilia is the absence of blasts in the peripheral blood, which can make early diagnosis of ALL difficult. The article describes the clinical case of 2-year-old patient with ALL and eosinophilia. due to the wide variety of etiologic factors of eosinophilia, which include allergic, infectious, immune agents, and a high risk of developing severe lesions of internal organs, physicians should conduct a broad differential diagnosis with the mandatory inclusion of malignant neoplasms in the diagnostic series. precise determination of the etiology of eosinophilia allows the correct diagnosis and etiotropic treatment.
About the Authors
O. D. Gurieva
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Oksana Dmitrievna Gurieva
24 Kashirskoe Shosse, Moscow 115478
T. T. Valiev
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
I. N. Serebryakova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
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Review
For citations:
Gurieva O.D., Valiev T.T., Serebryakova I.N. Acute lymphoblastic leukemia with eosinophilia: diagnostic and treatment features. Oncohematology. 2025;20(2):67-74. (In Russ.) https://doi.org/10.17650/1818-8346-2025-20-2-67-74
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