OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press98510.17650/1818-8346-2024-19-4-173-181CURRENT BASIC RESEARCH IN HEMATOLOGY AND PRACTICAL MEDICINEФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ОНКОГЕМАТОЛОГИИ И ПРАКТИЧЕСКОЙ МЕДИЦИНЕ НА СОВРЕМЕННОМ ЭТАПЕMetabolic profile of blast cells in acute myeloid leukemia. Literature reviewМетаболический профиль бластных клеток при остром миелоидном лейкозе. Обзор литературыhttps://orcid.org/0000-0003-4689-8904KhaliulinA. V.ХалиулинА. В.
Russian Federation

Almaz Vadimovich Khaliulin,

89 Chapaevskaya St., Samara 443099

Алмаз Вадимович Халиулин,

443099 Самара, ул. Чапаевская, 89

a.v.haliulin@samsmu.ruhttps://orcid.org/0009-0008-2721-4152ZaninI. I.ЗанинИ. И.
Russian Federation

89 Chapaevskaya St., Samara 443099

443099 Самара, ул. Чапаевская, 89

https://orcid.org/0000-0002-5905-1895LyaminA. V.ЛяминА. В.
Russian Federation

89 Chapaevskaya St., Samara 443099

443099 Самара, ул. Чапаевская, 89

https://orcid.org/0000-0002-4318-4247DavydkinI. L.ДавыдкинИ. Л.
Russian Federation

89 Chapaevskaya St., Samara 443099

443099 Самара, ул. Чапаевская, 89

https://orcid.org/0000-0001-6647-5330SeleznevaI. A.СелезневаИ. А.
Russian Federation

89 Chapaevskaya St., Samara 443099

443099 Самара, ул. Чапаевская, 89

Samara State Medical University, Ministry of Health of RussiaФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России101220241941731811012202410122024https://oncohematology.abvpress.ru/ongm/article/view/985

The article presents a review of new data on blast cells metabolism and its regulatory mechanisms in acute myeloid leukemia. Particular attention is given to the role of reactive oxygen species in the regulation of signaling pathways and metabolic processes, as well as their influence on the aggressiveness and resistance to chemotherapeutic agents in acute myeloid leukemia. Elevated levels of reactive oxygen species are associated with altered activity of enzymes and proteins involved in cell proliferation and survival. The article also discusses data on the iron role in the formation of malignancy in acute myeloid leukemia.

Представлен обзор новых данных о метаболизме и механизмах его регулирования в бластных клетках при остром миелоидном лейкозе. Основное внимание уделено роли активных форм кислорода в регуляции сигнальных путей и метаболических процессов, а также их влиянию на агрессивность острого миелоидного лейкоза и его резистентность к химиотерапевтическим препаратам. Повышенные уровни активных форм кислорода ассоциированы с измененной активностью ферментов и белков, участвующих в клеточной пролиферации и выживании. Также рассмотрены данные о роли железа в формировании злокачественности острого миелоидного лейкоза.

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