OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press9710.17650/1818-8346-2011-6-2-12-18HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯGonadal toxicity of Hodgkin lymphoma treatment in adolescents and young males: issue relevance and ways of solve (literature review)Гонадотоксичность терапии лимфомы Ходжкина у подростков и молодых мужчин: актуальность проблемы и пути решения (обзор литературы)VinokurovA. A.ВинокуровА. А.
Russian Federation
a_vinokurov@inbox.ruVarfolomeevaS. R.ВарфоломееваС. Р.
Russian Federation
TarusinD. I.ТарусинД. И.
Russian Federation
Federal Research Center of Pediatric Hematology, Oncology and ImmunologyФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии Минздравсоцразвития РоссииScientific and Practical Center of Children and Adolescents Andrology Moscow Department of Public HealthНаучно-практический центр детской и подростковой андрологии Департамента здравоохранения города Москвы2305201162121823072014230720142011https://oncohematology.abvpress.ru/ongm/article/view/97

Hodgkin`s Lymphoma (HL) is one of the most curable cancer disease. A half of all patients are young males under 35 years old. Gonadal toxicity is one of the most frequent late effects of HL therapy and associated with significant decrease in patient’s quality of life. In present article frequency and risk factors of gonadal toxicity in males with HL were summarized. It was shown that chemotherapy with alkylating agents and radiotherapy may lead to gonadal toxicity in significant number of patients. Current possibilities of semen cryopreservation before start of the treatment are discussed.

В настоящее время лимфома Ходжкина (ЛХ) – одно из наиболее курабельных опухолевых заболеваний, при этом более половины заболевших являются лицами мужского пола в возрасте до 35 лет. Гонадотоксичность служит одним из наиболее частых отдаленных последствий терапии ЛХ, что ассоциировано со значительным ухудшением качества жизни больных. В настоящей статье обобщены данные о частоте встречаемости и факторах риска развития гонадотоксичности у лиц мужского пола с ЛХ. Показано, что проведение химиотерапии с включением алкилирующих препаратов и лучевая терапия могут приводить к развитию гонадотоксичности у значительного числа больных. Рассмотрены современные возможности проведения криоконсервации спермы до начала противоопухолевой терапии.

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