OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press95410.17650/1818-8346-2024-19-3-215-223SUPPORTIVE THERAPY ASPECTSАСПЕКТЫ ПОДДЕРЖИВАЮЩЕЙ ТЕРАПИИClinical significance of infections caused by human 6A and 6B herpes viruses in allogeneic hematopoietic stem cells recipients in the post-transplant periodКлиническое значение инфекций, вызванных вирусами герпеса человека 6А и 6B, у реципиентов аллогенных гемопоэтических стволовых клеток в посттрансплантационном периодеhttps://orcid.org/0009-0005-3144-8187SaydullayevaI. S.СайдуллаеваИ. С.
Russian Federation

Inara S. Saydullayeva 

4 Novyy Zykovskiy Proezd, Moscow 125167

 

Инара Санджаровна Сайдуллаева 

125167 Москва, Новый Зыковский пр-д, 4

say-inara@mail.ruhttps://orcid.org/0000-0003-4668-9379TupolevaT. A.ТуполеваТ. А.
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

125167 Москва, Новый Зыковский пр-д, 4

https://orcid.org/0000-0002-2553-6579TikhomirovD. S.ТихомировД. С.
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

125167 Москва, Новый Зыковский пр-д, 4

https://orcid.org/0000-0001-9431-8316DrokovM. Yu.ДроковМ. Ю.
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

125167 Москва, Новый Зыковский пр-д, 4

National Medical Research Center for Hematology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России030920241932152230309202403092024https://oncohematology.abvpress.ru/ongm/article/view/954

Allogeneic hematopoietic stem cells transplantation is an effective method for the treatment of hematologic malignancies and other blood system diseases. Infections caused by human 6A and 6B herpes viruses are one of the leading causes of complications and mortality in hematology patients after allogeneic hematopoietic stem cell transplantation, especially in the first 100 days after transplantation. This review discusses the clinical features of infections caused by human herpes viruses 6A and 6B, their impact on the development of post-transplant complications, including graft-versus-host disease and graft failure, as well as methods of prevention and treatment.

Трансплантация аллогенных гемопоэтических стволовых клеток – эффективный метод терапии гемобластозов и неопухолевых заболеваний системы крови. Инфекции, вызванные вирусами герпеса человека 6A и 6B, являются одной из лидирующих причин осложнений и смертности пациентов гематологического профиля после трансплантации аллогенных гемопоэтических стволовых клеток, особенно в первые 100 дней после трансплантации. В данном обзоре рассматриваются клинические особенности инфекций, вызванных вирусами герпеса человека 6A и 6B, их влияние на развитие посттрансплантационных осложнений, в том числе реакции «трансплантат против хозяина» и несостоятельности трансплантата, а также методы профилактики и лечения.

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