OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press95110.17650/1818-8346-2024-19-3-185-198BASIC RESEARCHФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ПРАКТИЧЕСКОЙ МЕДИЦИНЕ НА СОВРЕМЕННОМ ЭТАПЕCAR-T: from bench to bedsideCAR-T: от идеи до примененияhttps://orcid.org/0000-0001-8536-5495PopovaM. О.ПоповаМ. О.
Russian Federation

Marina O. Popova 

6–8 L’va Tolstogo St., Saint Petersburg 197022

Марина Олеговна Попова 

197022 Санкт-Петербург, ул. Льва Толстого, 6–8

marina.popova.spb@gmail.comhttps://orcid.org/0009-0005-5537-6923MarkelovV. V.МаркеловВ. В.
Russian Federation

6–8 L’va Tolstogo St., Saint Petersburg 197022

197022 Санкт-Петербург, ул. Льва Толстого, 6–8

Raisa Gorbacheva Memorial Research Institute for Pediatric Oncology, Hematology and Transplantation, I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaНИИ детской онкологии, гематологии и трансплантологии им. Р.М. Горбачевой ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России030920241931851980309202403092024https://oncohematology.abvpress.ru/ongm/article/view/951

In current immunotherapy, a promising direction is therapy using chimeric antigen receptor T cells (CAR-T). Among malignant hematological diseases, even at advanced stages and resistant/recurrent forms, the use of CAR-T demonstrates high efficiency. The observed clinical success in patients with hematologic malignancies not only determines the ever-increasing list of indications for the use of CAR-T in this group of patients, but also motivates the study of this treatment method in solid oncology and autoimmune diseases. This review examines the history of the emergence and development of CAR-T, the path from the idea of creation to registration to clinical use.

В современной иммунотерапии перспективным направлением является терапия с помощью Т-лимфоцитов с химерным антигенным рецептором (CAR-T). Среди злокачественных гематологических заболеваний даже при продвинутых стадиях и резистентных/рецидивирующих формах применение CAR-T демонстрирует высокую эффективность. Наблюдаемый клинический успех у пациентов с гемобластозами не только обусловливает постоянно увеличивающийся список показаний к применению CAR-T в этой группе больных, но и мотивирует исследовать данный метод лечения в солидной онкологии и при аутоиммунных заболеваниях. В настоящем обзоре рассматриваются история появления и развития CAR-T, путь от идеи создания до регистрации к клиническому применению.

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Минздрав зарегистрировал лекарство от рака за 39 млн рублей. Доступно по: https://rg.ru/2023/04/19/minzdrav-zaregistriroval-lekarstvo-ot-raka-za-39-mln-rublej.html