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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">95</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2011-6-2-4-7</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Treatment of patients with refractory chronic lymphocytic leukemia with alemtuzumab, alone or in combination with fludarabine</article-title><trans-title-group xml:lang="ru"><trans-title>Лечение резистентных больных хроническим лимфолейкозом программами, включающими алемтузумаб в виде монотерапии или в сочетании с флударабином</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kataeva</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Катаева</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>e.kataeva2010@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Golenkov</surname><given-names>A. K.</given-names></name><name xml:lang="ru"><surname>Голенков</surname><given-names>А. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Trifonova</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Трифонова</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dudina</surname><given-names>G. A.</given-names></name><name xml:lang="ru"><surname>Дудина</surname><given-names>Г. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mitina</surname><given-names>T. A.</given-names></name><name xml:lang="ru"><surname>Митина</surname><given-names>Т. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vysotskaya</surname><given-names>L. L.</given-names></name><name xml:lang="ru"><surname>Высоцкая</surname><given-names>Л. Л.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lutskaya</surname><given-names>T. D.</given-names></name><name xml:lang="ru"><surname>Луцкая</surname><given-names>Т. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Buravtsova</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Буравцова</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gorenkov</surname><given-names>R. V.</given-names></name><name xml:lang="ru"><surname>Горенков</surname><given-names>Р. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chuksina</surname><given-names>Yu. Yu.</given-names></name><name xml:lang="ru"><surname>Чуксина</surname><given-names>Ю. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yazdovskiy</surname><given-names>V. V.</given-names></name><name xml:lang="ru"><surname>Яздовский</surname><given-names>В. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">M.F. Vladimirsky Moscow Regional Research Clinical Institute</institution></aff><aff><institution xml:lang="ru">ГУ Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-05-23" publication-format="electronic"><day>23</day><month>05</month><year>2011</year></pub-date><volume>6</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>4</fpage><lpage>7</lpage><history><date date-type="received" iso-8601-date="2014-07-23"><day>23</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-23"><day>23</day><month>07</month><year>2014</year></date></history><permissions><copyright-year>2011</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/95">https://oncohematology.abvpress.ru/ongm/article/view/95</self-uri><abstract xml:lang="en"><p>In present study the immediate and long-term therapy results of 14 patients with refractory chronic lymphocytic leukemia (CLL) are analyzed. Treatment program included alemtuzumab alone or in combination with fludarabine.</p></abstract><trans-abstract xml:lang="ru"><p>В настоящем исследовании изучены непосредственные и отдаленные результаты лечения 14 резистентных больных хроническим лимфолейкозом (ХЛЛ) программами, включающими алемтузумаб в виде монотерапии и в сочетании с флударабином.</p></trans-abstract><kwd-group xml:lang="en"><kwd>chronic lymphocytic leukemia</kwd><kwd>resistant patients</kwd><kwd>alemtuzumab</kwd><kwd>fludarabine</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хронический лимфолейкоз</kwd><kwd>резистентные больные</kwd><kwd>алемтузумаб</kwd><kwd>флударабин</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Rai K.R., Peterson B.L., Appelbaum F.R. et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. 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