OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press94710.17650/1818-8346-2024-19-3-149-152RARE AND COMPLEX CLINICAL SITUATIONS: DIAGNOSIS AND TREATMENT CHOICEРЕДКИЕ И СЛОЖНЫЕ КЛИНИЧЕСКИЕ СИТУАЦИИ: ДИАГНОСТИКА И ВЫБОР ТАКТИКИ ЛЕЧЕНИЯTrisomy 14 as the only cytogenetic abnormality in myelodysplastic syndromeТрисомия 14 как единственная цитогенетическая аномалия при миелодиспластическом синдромеhttps://orcid.org/0009-0004-7215-791XPautovaM. N.ПаутоваМ. Н.
Russian Federation

Marina N. Pautova 

41 Kirochnaya St., Saint Petersburg 191015

Марина Николаевна Паутова 

191015 Санкт-Петербург, ул. Кирочная, 41

paytova.marinaa@gmail.comhttps://orcid.org/0000-0002-5221-8832KoloskovaL. E.КолосковаЛ. Е.
Russian Federation

71A Obukhovskoy Oborony Prospekt, Saint Petersburg 192029

192029 Санкт-Петербург, пр-кт Обуховской обороны, 71А

https://orcid.org/0000-0001-8142-5278FilippovaO. I.ФилипповаО. И.
Russian Federation

41 Kirochnaya St., Saint Petersburg 191015

191015 Санкт-Петербург, ул. Кирочная, 41

https://orcid.org/0000-0002-5249-4255KoloskovA. V.КолосковА. В.
Russian Federation

41 Kirochnaya St., Saint Petersburg 191015

191015 Санкт-Петербург, ул. Кирочная, 41

I.I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииMedical Laboratory SPbООО «Медицинская лаборатория СПб»030920241931491520209202402092024https://oncohematology.abvpress.ru/ongm/article/view/947

Evaluation of bone marrow cytogenetic abnormalities in myelodysplastic syndrome is of great importance for confirming the clonal disease nature, determining the prognosis and choosing treatment tactics. Cytogenetic abnormalities are detected in 40–70 % of patients with myelodysplastic syndrome, and the variety of these abnormalities reflects the disease characteristics.

This article describes the clinical follow-up of a patient with a myelodysplastic neoplasia with blast excess 1 and trisomy of chromosome 14.

Оценка цитогенетических аномалий в костном мозге пациентов с миелодиспластическим синдромом имеет большое значение для подтверждения клональной природы заболевания, определения прогноза и выбора тактики лечения. Цитогенетические аномалии выявляют у 40–70 % пациентов с миелодиспластическим синдромом, и разнообразие этих аномалий отражает особенности заболевания.

В статье приводится описание клинического наблюдения пациента с миелодиспластическим новообразованием с избытком бластов-1 и трисомией хромосомы 14. Представлены результаты лабораторных и морфологических исследований, а также обсуждается влияние трисомии хромосомы 14 на прогноз состояния пациента.

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