OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press9210.17650/1818-8346-2011-6-3-65-75BASIC RESEARCHФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ПРАКТИЧЕСКОЙ МЕДИЦИНЕ НА СОВРЕМЕННОМ ЭТАПЕP53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesisНарушения в системе белка р53 и их влияние на патогенез хронических лимфопролиферативных заболеванийKondratovskiyP. M.КондратовскийП. М.
Russian Federation
k855va@gmail.comDubikovA. I.ДубиковА. И.
Russian Federation
DoroshevskayaA. Yu.ДорошевскаяА. Ю.
Russian Federation
Vladivostok State Medical UniversityВладивостокский государственный медицинский университет2308201163657523072014230720142011https://oncohematology.abvpress.ru/ongm/article/view/92

The role of p53 family proteins, both in the pathogenesis of chronic lymphoproliferative disorders, and in aspects of the growi ng interest in thetherapeutic potential of so-called small molecules capable of influencing the regulatory "relationship" of p53, MDM2, p21 and P UMA is currently actively debated. The article is an attempt to summarize the data on experimental tumor and mouse models and availablen ithe l iterature results of studies using human lymphoid tumors. Prognostic significance of p53 family proteins expression in lymphoproliferativ e diseases and possible therapeutic approaches using the features of the p53 relationship with regulators and effectors genes are considered.

В настоящее время активно обсуждается роль белков семейства р53 как в рамках патогенеза хронических лимфопролиферативных заболеваний, так и в свете растущего интереса к терапевтическому потенциалу так называемых малых молекул, способных влиять на регуляторные «взаимоотношения» молекул р53, MDM2, p21 и PUM A. Представленная статья является попыткой обобщить данные экспериментальных моделей на тканях опухоли и мышиных моделях и доступных в литературе исследований с использованием материала лимфоидных опухолей человека. Рассмотрены как аспекты прогностической значимости экспрессии белков семейства р53 при лимфопролиферативных заболеваниях, так и возможные терапевтические подходы, использующиеособенности взаимоотношений р53-молекулы с генами-регуляторами и эффекторами.

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