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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">89</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2011-6-3-39-49</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Patogenetic correction of anemia with erythropoiesis-stimulating agents in lymphoproliferative disorders (literature review)</article-title><trans-title-group xml:lang="ru"><trans-title>Патогенетическая коррекция анемии эритропоэзстимулирующими препаратами у больных лимфопролиферативными заболеваниями (обзор литературы)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Romanenko</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Романенко</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>rom-nik@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Abdulkadyrov</surname><given-names>K. M.</given-names></name><name xml:lang="ru"><surname>Абдулкадыров</surname><given-names>К. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Research Institute of Hematology and Transfusiology, Russian Federal Medico-biological Agency</institution></aff><aff><institution xml:lang="ru">ФГУ Российский научно-исследовательский институт гематологии и трансфузиологии ФМБА России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-08-23" publication-format="electronic"><day>23</day><month>08</month><year>2011</year></pub-date><volume>6</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>39</fpage><lpage>49</lpage><history><date date-type="received" iso-8601-date="2014-07-23"><day>23</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-23"><day>23</day><month>07</month><year>2014</year></date></history><permissions><copyright-year>2011</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/89">https://oncohematology.abvpress.ru/ongm/article/view/89</self-uri><abstract xml:lang="en"><p>Literature review of anemia pathogenesis in patients with lymphatic system malignancies is presented. Advantages and disadvanta ges of eritropoiesis-stimulating preparations (ESP) used for anemia correction are shown. Efficacy of anemia treatment with ESP in various types of lymphoproliferative disorders (LPD) is presented. Prognostic factors that predict positive response on ESP in LPD pati ents and reduce treatment cost are identified.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен обзор литературы по патогенезу анемического синдрома (АС) у больных с опухолевыми заболеваниями лимфатической системы. Показаны преимущества и недостатки эритропоэзстимулирующих препаратов (Э ПСП), используемых для коррекции АС. Проведен анализ результативности лечения анемического синдрома с помощью Э ПСП при различных видах лимфопролиферативных заболеваний (ЛПЗ). Выделены прогностические факторы, позволяющие предсказать положительный ответ ЭПСП у больных ЛПЗ и снижающие стоимость лечения больных.</p></trans-abstract><kwd-group xml:lang="en"><kwd>anemic syndrome</kwd><kwd>non Hodgkin’s lymphomas</kwd><kwd>lymphoproliferative disorders</kwd><kwd>multiple myeloma</kwd><kwd>anemia treatment</kwd><kwd>erythropoietin</kwd><kwd>erythropoiesis-stimulating agents</kwd><kwd>cytokine</kwd><kwd>chemotherapy</kwd><kwd>red blood cell transfusion</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>анемический синдром</kwd><kwd>неходжкинские лимфомы</kwd><kwd>лимфопролиферативные заболевания</kwd><kwd>множественная миелома</kwd><kwd>лечение анемии</kwd><kwd>эритропоэтин</kwd><kwd>эритропоэзстимулирующие препараты</kwd><kwd>цитокины</kwd><kwd>химиотерапия</kwd><kwd>трансфузии эритроцитов</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Blackwell K., Gascón P., Sigounas G., Jolliffe L. rHuEPO and improved treatment outcomes: potential modes of action. Oncologist 2004;9(Suppl 5):41–7.</mixed-citation><mixed-citation xml:lang="ru">Blackwell K., Gascón P., Sigounas G., Jolliffe L. rHuEPO and improved treatment outcomes: potential modes of action. Oncologist 2004;9(Suppl 5):41–7.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. De Gaona E.R., Rifón J., Pérez-Calvo J. et al. Anemia in chronic lymphatic leukemi a: is erythropoietin the solution. Rev Med Univ Navarra 2007;51(1):3–10.</mixed-citation><mixed-citation xml:lang="ru">De Gaona E.R., Rifón J., Pérez-Calvo J. et al. Anemia in chronic lymphatic leukemi a: is erythropoietin the solution. Rev Med Univ Navarra 2007;51(1):3–10.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Zinzani P.L., Tani M., Alinari L. et al. Role of anemia in survival of patients with elderly aggressive non-Hodgkin’s lymphoma after chemotherapy. Leuk Lymphoma 2005;46(10):1449–54.</mixed-citation><mixed-citation xml:lang="ru">Zinzani P.L., Tani M., Alinari L. et al. Role of anemia in survival of patients with elderly aggressive non-Hodgkin’s lymphoma after chemotherapy. Leuk Lymphoma 2005;46(10):1449–54.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Samuelsson J. Long-standing resolution of anemia in symptomatic low-grade non- Hodgkin’s lymphoma patients treated with recombinant human erythropoietin as sole therapy. Med Oncol 2002;19(1):69–72.</mixed-citation><mixed-citation xml:lang="ru">Samuelsson J. Long-standing resolution of anemia in symptomatic low-grade non- Hodgkin’s lymphoma patients treated with recombinant human erythropoietin as sole therapy. Med Oncol 2002;19(1):69–72.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Kyle R.A. Multiple myeloma: review of 869 cases. Mayo Clin Proc 1975;50:29–40.</mixed-citation><mixed-citation xml:lang="ru">Kyle R.A. Multiple myeloma: review of 869 cases. Mayo Clin Proc 1975;50:29–40.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Ludwig H. Anemia of hematologic malignancies: what are the treatment options? Semin Oncol 2002;29 (3 Suppl 8):45–54. 7. Moullet I., Salles G., Ketterer N. et al. Frequency and significance of anemia in non-Hodgkin’s lymphoma patients. Ann Oncol 1998;9:1109–15.</mixed-citation><mixed-citation xml:lang="ru">Ludwig H. Anemia of hematologic malignancies: what are the treatment options? Semin Oncol 2002;29 (3 Suppl 8):45–54. 7. Moullet I., Salles G., Ketterer N. et al. Frequency and significance of anemia in non-Hodgkin’s lymphoma patients. Ann Oncol 1998;9:1109–15.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">8. Straus D.J. Epoetin alfa therapy for parameters with hematologic malignancies and mild anemia. Clin Lymphoma 2003;4(Suppl 1):13–7.</mixed-citation><mixed-citation xml:lang="ru">Straus D.J. Epoetin alfa therapy for parameters with hematologic malignancies and mild anemia. Clin Lymphoma 2003;4(Suppl 1):13–7.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">9. Dammacco F., Luccarelli G., Prete M., Silvestris F. The role of recombinant human erythropoietin alpha in the treatment of chronic anemia in multiple myeloma. Rev Clin Exp Hematol 2002;Suppl 1:32–8.</mixed-citation><mixed-citation xml:lang="ru">Dammacco F., Luccarelli G., Prete M., Silvestris F. The role of recombinant human erythropoietin alpha in the treatment of chronic anemia in multiple myeloma. Rev Clin Exp Hematol 2002;Suppl 1:32–8.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">10. Truong P.T., Parhar T., Hart J. et al. Population-based analysis of the frequency of anemia and its management before and during chemotherapy in patients with malignant lymphoma. Am J Clin Oncol 2010;33(5):465–8.</mixed-citation><mixed-citation xml:lang="ru">Truong P.T., Parhar T., Hart J. et al. Population-based analysis of the frequency of anemia and its management before and during chemotherapy in patients with malignant lymphoma. Am J Clin Oncol 2010;33(5):465–8.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">11. Steurer M., Wagner H., Gastel G. Prevalence and management of anaemia in haematologic cancer patients receiving cyclic nonplatinum chemotherapy: results of a prospective national chart survey. Wien Klin Wochenschr 2004;116(11–12):367–72.</mixed-citation><mixed-citation xml:lang="ru">Steurer M., Wagner H., Gastel G. Prevalence and management of anaemia in haematologic cancer patients receiving cyclic nonplatinum chemotherapy: results of a prospective national chart survey. Wien Klin Wochenschr 2004;116(11–12):367–72.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">12. Hershman D.L., Buono D.L. et al. Patterns of Use and Risks Associated With Erythropoiesis-Stimulating Agents Among Medicare Patients With Cancer. J Natl Cancer Inst 2009;101(23):1633–41.</mixed-citation><mixed-citation xml:lang="ru">Hershman D.L., Buono D.L. et al. Patterns of Use and Risks Associated With Erythropoiesis-Stimulating Agents Among Medicare Patients With Cancer. J Natl Cancer Inst 2009;101(23):1633–41.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">13. Богданов А.Н., Новик А.А. Диагностика и дифференциальная диагностика анемий. Вестн Гематологии 2005;1(4):63–70.</mixed-citation><mixed-citation xml:lang="ru">Богданов А.Н., Новик А.А. Диагностика и дифференциальная диагностика анемий. Вестн Гематологии 2005;1(4):63–70.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">14. Mittelman M. The implications of anemia in multiple myeloma. Clin Lymphoma 2003;4(Suppl 1):23–9.</mixed-citation><mixed-citation xml:lang="ru">Mittelman M. The implications of anemia in multiple myeloma. Clin Lymphoma 2003;4(Suppl 1):23–9.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">15. Hudis C.A., van Belle S., Chang J., Muenstedt K. rHuEPO and treatment outcomes: the clinical experience. Oncologist 2004;9(Suppl 5):55–69.</mixed-citation><mixed-citation xml:lang="ru">Hudis C.A., van Belle S., Chang J., Muenstedt K. rHuEPO and treatment outcomes: the clinical experience. Oncologist 2004;9(Suppl 5):55–69.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">16. Eve H.E., Rule S.A. Autoimmune haemolytic anaemia associated with mantle cell lymphoma. Int J Hematol 2010;91(2):322–5.</mixed-citation><mixed-citation xml:lang="ru">Eve H.E., Rule S.A. Autoimmune haemolytic anaemia associated with mantle cell lymphoma. Int J Hematol 2010;91(2):322–5.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">17. Zent C.S., Ding W., Reinalda M.S. et al. Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: changes in clinical presentationand prognosis. Leuk Lymphoma 2009;50(8):1261–8.</mixed-citation><mixed-citation xml:lang="ru">Zent C.S., Ding W., Reinalda M.S. et al. Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: changes in clinical presentationand prognosis. Leuk Lymphoma 2009;50(8):1261–8.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">18. Gaya A., Urbano-Ispizua A., Fernández-Avilés F. et al. Anemia associated with impaired rythropoietin secretion after allogeneic stem cell transplantation: incidence, risk factors, and response to treatment. Biol Blood Marrow Transplant 2008; 14(8):880–7.</mixed-citation><mixed-citation xml:lang="ru">Gaya A., Urbano-Ispizua A., Fernández-Avilés F. et al. Anemia associated with impaired rythropoietin secretion after allogeneic stem cell transplantation: incidence, risk factors, and response to treatment. Biol Blood Marrow Transplant 2008; 14(8):880–7.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">19. Mauro F.R., Gentile M., Foa R. Erythropoietin and chronic lymphocytic leukemia. Rev Clin Exp Hematol 2002;Suppl 1:21–31.</mixed-citation><mixed-citation xml:lang="ru">Mauro F.R., Gentile M., Foa R. Erythropoietin and chronic lymphocytic leukemia. Rev Clin Exp Hematol 2002;Suppl 1:21–31.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">20. Гусева С.А. Анемии при хронических и опухолевых заболеваниях. Укр журн гематологии и трансфузиологии 2003;4:32–8.</mixed-citation><mixed-citation xml:lang="ru">Гусева С.А. Анемии при хронических и опухолевых заболеваниях. Укр журн гематологии и трансфузиологии 2003;4:32–8.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">21. Мулле И., Саль Г., Кеттерер Н. и др. Частота и значение анемии у больных с неходжкинскими лимфомами. Анемия у онкол больных 2002;1:19–21.</mixed-citation><mixed-citation xml:lang="ru">Мулле И., Саль Г., Кеттерер Н. и др. Частота и значение анемии у больных с неходжкинскими лимфомами. Анемия у онкол больных 2002;1:19–21.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">22. Littlewood T., Mandelli F. The effects of anemia in hematologic malignancies: more than a symptom. Semin Oncol 2002;29(3)Suppl 8:40–4.</mixed-citation><mixed-citation xml:lang="ru">Littlewood T., Mandelli F. The effects of anemia in hematologic malignancies: more than a symptom. Semin Oncol 2002;29(3)Suppl 8:40–4.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">23. Pierce C.N., Larson D.F. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion 2005;20(2):83–90.</mixed-citation><mixed-citation xml:lang="ru">Pierce C.N., Larson D.F. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion 2005;20(2):83–90.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">24. Rizzo J.D., Lichtin A.E., Woolf S.H. et al. Use of epoetin in patients with cancer: evidence-based clinical practice guidelines of the American Society of Clinical Oncology and the American Society of Hematology. Blood 2002;100(7):2303–20.</mixed-citation><mixed-citation xml:lang="ru">Rizzo J.D., Lichtin A.E., Woolf S.H. et al. Use of epoetin in patients with cancer: evidence-based clinical practice guidelines of the American Society of Clinical Oncology and the American Society of Hematology. Blood 2002;100(7):2303–20.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">25. Птушкин В.В. Дискуссионные вопросы применения эритропоэтинов в лечении анемии у пациентов с опухолевыми заболеваниями. Онкогематология 2007;2:31–6.</mixed-citation><mixed-citation xml:lang="ru">Птушкин В.В. Дискуссионные вопросы применения эритропоэтинов в лечении анемии у пациентов с опухолевыми заболеваниями. Онкогематология 2007;2:31–6.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">26. Lombard M., Chua E., O’Toole P. Regulation of intestinal non-haem iron absorbtion. Gut 1997;40:435–9.</mixed-citation><mixed-citation xml:lang="ru">Lombard M., Chua E., O’Toole P. Regulation of intestinal non-haem iron absorbtion. Gut 1997;40:435–9.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">27. Johnson R.A., Waddelow T.A., Caro J. et al. Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice. Blood 1989; 74:130–8.</mixed-citation><mixed-citation xml:lang="ru">Johnson R.A., Waddelow T.A., Caro J. et al. Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice. Blood 1989; 74:130–8.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">28. Moldawer L.L., Marano M.A., Wei H. et al. Cachectin/tumor necrosis factoralpha alters red blood cell kinetics and induces anemia in vivo. FASEB J 1989; 3:1637–43.</mixed-citation><mixed-citation xml:lang="ru">Moldawer L.L., Marano M.A., Wei H. et al. Cachectin/tumor necrosis factoralpha alters red blood cell kinetics and induces anemia in vivo. FASEB J 1989; 3:1637–43.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">29. Сараева Н.О. Механизмы развития анемии при гемобластозах. Гематол и трансфузиол 2007;52(1):31–7.</mixed-citation><mixed-citation xml:lang="ru">Сараева Н.О. Механизмы развития анемии при гемобластозах. Гематол и трансфузиол 2007;52(1):31–7.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">30. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47–95.</mixed-citation><mixed-citation xml:lang="ru">Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47–95.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">31. Tsopra O.A., Ziros P.G., Lagadinou E.D. et al. Disease-related anemia in chronic lymphocytic leukemia is not due to intrinsic defects of erythroid precursors: a possible pathogenetic role for tumor necrosis factoralpha. Acta Haematol 2009;121(4):187–95.</mixed-citation><mixed-citation xml:lang="ru">Tsopra O.A., Ziros P.G., Lagadinou E.D. et al. Disease-related anemia in chronic lymphocytic leukemia is not due to intrinsic defects of erythroid precursors: a possible pathogenetic role for tumor necrosis factoralpha. Acta Haematol 2009;121(4):187–95.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">32. Гуревич К.Я., Константинов Ю.В., Коробицын Л.П. и др. Человеческий рекомбинантный эритропоэтин (эпокрин) в лечении анемии. Практическое руководство. СПб., 2004. 60 с.</mixed-citation><mixed-citation xml:lang="ru">Гуревич К.Я., Константинов Ю.В., Коробицын Л.П. и др. Человеческий рекомбинантный эритропоэтин (эпокрин) в лечении анемии. Практическое руководство. СПб., 2004. 60 с.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">33. Павлов А.Д., Морщакова Е.Ф., Демихов В.Г. и др. Применение рекормона (человеческого рекомбинантного эритропоэтина бета) в лечении эритропоэтиндефицитных анемий у детей и подростков. Пособие для врачей-гематологов и педиатров. Рязань, 2004. 48 с.</mixed-citation><mixed-citation xml:lang="ru">Павлов А.Д., Морщакова Е.Ф., Демихов В.Г. и др. Применение рекормона (человеческого рекомбинантного эритропоэтина бета) в лечении эритропоэтиндефицитных анемий у детей и подростков. Пособие для врачей-гематологов и педиатров. Рязань, 2004. 48 с.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">34. Романенко Н.А. Коррекция и лечение анемии у больных с гемобластозами эритроцитсодержащими компонентами крови и препаратами рекомбинантного эритропоэтина. Вестн Гематологии 2007;3(4):46–54.</mixed-citation><mixed-citation xml:lang="ru">Романенко Н.А. Коррекция и лечение анемии у больных с гемобластозами эритроцитсодержащими компонентами крови и препаратами рекомбинантного эритропоэтина. Вестн Гематологии 2007;3(4):46–54.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">35. Singh A., Eckardt K.U., Limmermann A. et al. Increased plasma viscosity as a reason for inappropriate erythropoietin formation. J Clin Invest 1993;91:251–6.</mixed-citation><mixed-citation xml:lang="ru">Singh A., Eckardt K.U., Limmermann A. et al. Increased plasma viscosity as a reason for inappropriate erythropoietin formation. J Clin Invest 1993;91:251–6.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">36. Takagi M., Migamoto Y., Kosaka M. et al. Clinical significance of serum erythropoietin levels in patients with multiple myeloma. Rinsho Ketsueki 1992;33:1151–7.</mixed-citation><mixed-citation xml:lang="ru">Takagi M., Migamoto Y., Kosaka M. et al. Clinical significance of serum erythropoietin levels in patients with multiple myeloma. Rinsho Ketsueki 1992;33:1151–7.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">37. Han B., Shi Y.K., Zhu J. et al. Study on serum erythropoietin levels in patients with hematologic malignancies. Zhonghua Xue Ye Xue Za Zhi 2006;27(8):543–5.</mixed-citation><mixed-citation xml:lang="ru">Han B., Shi Y.K., Zhu J. et al. Study on serum erythropoietin levels in patients with hematologic malignancies. Zhonghua Xue Ye Xue Za Zhi 2006;27(8):543–5.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">38. Osterborg A., Boogaerts M.A., Cimino R. et al. Recombinant human erythropoietin in transfusion-dependent anemic patients with multiple myeloma and non-Hodgkin’s lymphoma — a randomized multicenter study. The European Study Group of Erythropoietin (Epoetin Beta) Treatment in Multiple Myeloma and Non-Hodgkin’s Lymphoma. Blood 1996;87(7):2675–82.</mixed-citation><mixed-citation xml:lang="ru">Osterborg A., Boogaerts M.A., Cimino R. et al. Recombinant human erythropoietin in transfusion-dependent anemic patients with multiple myeloma and non-Hodgkin’s lymphoma — a randomized multicenter study. The European Study Group of Erythropoietin (Epoetin Beta) Treatment in Multiple Myeloma and Non-Hodgkin’s Lymphoma. Blood 1996;87(7):2675–82.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">39. Поспелова Т.И., Лямкина А.С. Уровень цитокинов (интерлейкина-1β, фактора некроза опухолей-α, интерферона-γ, интерлейкина-6) у больных лимфопролиферативными заболеваниями с анемическим синдромом. Анемия при лимфомах: научное издание. НГМУ, Новосибирск, 2008. С. 97–114.</mixed-citation><mixed-citation xml:lang="ru">Поспелова Т.И., Лямкина А.С. Уровень цитокинов (интерлейкина-1β, фактора некроза опухолей-α, интерферона-γ, интерлейкина-6) у больных лимфопролиферативными заболеваниями с анемическим синдромом. Анемия при лимфомах: научное издание. НГМУ, Новосибирск, 2008. С. 97–114.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">40. Ludwig H., Fritz E. Anemia in Cancer patients. Semin Oncol 1998; 25(3)Suppl 7:2–6.</mixed-citation><mixed-citation xml:lang="ru">Ludwig H., Fritz E. Anemia in Cancer patients. Semin Oncol 1998; 25(3)Suppl 7:2–6.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">41. Абдулкадыров К.М. Переливания эритроцитов. В кн. Клиническая гематология: Справочник. СПб.: Питер, 2006. С. 403–406.</mixed-citation><mixed-citation xml:lang="ru">Абдулкадыров К.М. Переливания эритроцитов. В кн. Клиническая гематология: Справочник. СПб.: Питер, 2006. С. 403–406.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">42. Приказ Минздрава РФ № 363 от 25 ноября 2002 года «Об утверждении Инструкции по применению компо нентов крови».</mixed-citation><mixed-citation xml:lang="ru">Приказ Минздрава РФ № 363 от 25 ноября 2002 года «Об утверждении Инструкции по применению компо нентов крови».</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">43. Шевченко Ю.Л., Заривчацкий М.Ф., Жибурт Е.Б. Трансфузионные осложнения и их рофилактика. В кн.: Шев ченко Ю.Л., Шабалин В.Н., Заривчацкий М.Ф., Селиванов Е.А. (ред.) Руководство по общей и клинической трансфузиологии. СПб.: ООО «Издательство Фолиант», 2003. С. 561–588.</mixed-citation><mixed-citation xml:lang="ru">Шевченко Ю.Л., Заривчацкий М.Ф., Жибурт Е.Б. Трансфузионные осложнения и их рофилактика. В кн.: Шев ченко Ю.Л., Шабалин В.Н., Заривчацкий М.Ф., Селиванов Е.А. (ред.) Руководство по общей и клинической трансфузиологии. СПб.: ООО «Издательство Фолиант», 2003. С. 561–588.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">44. Ильина Е.Н., Говорун В.М. и Иваников И.О. Некоторые аспекты лабора торной диагностики вирусных гепатитов В и С. Тер арх 2003;75(4): 84–6.</mixed-citation><mixed-citation xml:lang="ru">Ильина Е.Н., Говорун В.М. и Иваников И.О. Некоторые аспекты лабора торной диагностики вирусных гепатитов В и С. Тер арх 2003;75(4): 84–6.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">45. Елов А.А., Федоров Н.А. и Жибурт Е.Б. Универсальные технологии генотестирования донорской крови и других клинических материалов на патогены. Трансфузиология 2006;7(3):98–118.</mixed-citation><mixed-citation xml:lang="ru">Елов А.А., Федоров Н.А. и Жибурт Е.Б. Универсальные технологии генотестирования донорской крови и других клинических материалов на патогены. Трансфузиология 2006;7(3):98–118.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">46. Ярославцева Н.Г., Грумбкова Л.О., Туполева Т.А. и др. Вирусная безопасность гемотрансфузий: обеспечивают ли ее принятые лабораторные методы выбраковки донорской крови по гепатитам В и С. Г ематол и трансфузиол 2006;51(2):22–6.</mixed-citation><mixed-citation xml:lang="ru">Ярославцева Н.Г., Грумбкова Л.О., Туполева Т.А. и др. Вирусная безопасность гемотрансфузий: обеспечивают ли ее принятые лабораторные методы выбраковки донорской крови по гепатитам В и С. Г ематол и трансфузиол 2006;51(2):22–6.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">47. Жибурт Е.Б., Караваев А.В., Филина Н.Г., Губанова М.Н. Модернизация бактериальной безопасности в трансфузиологии. Трансфузиология 2011;11(4):38–48.</mixed-citation><mixed-citation xml:lang="ru">Жибурт Е.Б., Караваев А.В., Филина Н.Г., Губанова М.Н. Модернизация бактериальной безопасности в трансфузиологии. Трансфузиология 2011;11(4):38–48.</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">48. Theakston E.P., Morris A.J., Streat S.J. et al. Transfusion transmitted Yersinia enterocolitica infection in New Zealand. Ausr N Z Med 1997;27(1):62–7.</mixed-citation><mixed-citation xml:lang="ru">Theakston E.P., Morris A.J., Streat S.J. et al. Transfusion transmitted Yersinia enterocolitica infection in New Zealand. Ausr N Z Med 1997;27(1):62–7.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">49. Brecher M.E., Hay S.N. Bacterial contamination of blood components. Clin Microbiol Rev 2005;18(1):195–204.</mixed-citation><mixed-citation xml:lang="ru">Brecher M.E., Hay S.N. Bacterial contamination of blood components. Clin Microbiol Rev 2005;18(1):195–204.</mixed-citation></citation-alternatives></ref><ref id="B49"><label>49.</label><citation-alternatives><mixed-citation xml:lang="en">50. Kuehnert M.J., Roth V.R., Haley N.R. et al. Transfusion-transmitted bacterial infection in the United States, 1998 through 2000. Transfusion 2001;41(12):1493–9.</mixed-citation><mixed-citation xml:lang="ru">Kuehnert M.J., Roth V.R., Haley N.R. et al. Transfusion-transmitted bacterial infection in the United States, 1998 through 2000. Transfusion 2001;41(12):1493–9.</mixed-citation></citation-alternatives></ref><ref id="B50"><label>50.</label><citation-alternatives><mixed-citation xml:lang="en">51. Hershman D.L., Buono D.L., Malin J. et al. Patterns of use and risks associated with erythropoiesis-stimulating agents among Medicare patients with cancer. J Natl Cancer Inst 2009;101(23):1633–41.</mixed-citation><mixed-citation xml:lang="ru">Hershman D.L., Buono D.L., Malin J. et al. Patterns of use and risks associated with erythropoiesis-stimulating agents among Medicare patients with cancer. J Natl Cancer Inst 2009;101(23):1633–41.</mixed-citation></citation-alternatives></ref><ref id="B51"><label>51.</label><citation-alternatives><mixed-citation xml:lang="en">52. Henke M., Laszig R., Rube C. et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet 2003;362:1255–60.</mixed-citation><mixed-citation xml:lang="ru">Henke M., Laszig R., Rube C. et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet 2003;362:1255–60.</mixed-citation></citation-alternatives></ref><ref id="B52"><label>52.</label><citation-alternatives><mixed-citation xml:lang="en">53. Wright J.R., Ung Y.C., Julian J.A. et al. Randomized, double-blind, placebocontrolled trial of erythropoietin in nonsmall-cell lung cancer with disease-related anemia. J Clin Oncol 2007;25(9):1027–32.</mixed-citation><mixed-citation xml:lang="ru">Wright J.R., Ung Y.C., Julian J.A. et al. Randomized, double-blind, placebocontrolled trial of erythropoietin in nonsmall-cell lung cancer with disease-related anemia. J Clin Oncol 2007;25(9):1027–32.</mixed-citation></citation-alternatives></ref><ref id="B53"><label>53.</label><citation-alternatives><mixed-citation xml:lang="en">54. Henry D.H. Guidelines and recommendations for the management of anemia in patients with lymphoid malignancies. Drugs 2007;67(2):175–94.</mixed-citation><mixed-citation xml:lang="ru">Henry D.H. Guidelines and recommendations for the management of anemia in patients with lymphoid malignancies. Drugs 2007;67(2):175–94.</mixed-citation></citation-alternatives></ref><ref id="B54"><label>54.</label><citation-alternatives><mixed-citation xml:lang="en">55. Bennett C.L., Silver S.M., Djulbegovic B. et al. Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia. JAMA 2008;299(8):914–24.</mixed-citation><mixed-citation xml:lang="ru">Bennett C.L., Silver S.M., Djulbegovic B. et al. Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia. JAMA 2008;299(8):914–24.</mixed-citation></citation-alternatives></ref><ref id="B55"><label>55.</label><citation-alternatives><mixed-citation xml:lang="en">56. Bohlius J., Wilson J., Seidenfeld J. et al. Recombinant human erythropoietins and cancer patients: updated meta-analysis of 57 studies including 9353 patients. J Natl Cancer Inst 2006;98(10):708–14.</mixed-citation><mixed-citation xml:lang="ru">Bohlius J., Wilson J., Seidenfeld J. et al. Recombinant human erythropoietins and cancer patients: updated meta-analysis of 57 studies including 9353 patients. J Natl Cancer Inst 2006;98(10):708–14.</mixed-citation></citation-alternatives></ref><ref id="B56"><label>56.</label><citation-alternatives><mixed-citation xml:lang="en">57. Bohlius J., Schmidlin K., Brillant C. et al. Recombinant human erythropoiesisstimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials. Lancet 2009;373:1532–42.</mixed-citation><mixed-citation xml:lang="ru">Bohlius J., Schmidlin K., Brillant C. et al. Recombinant human erythropoiesisstimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials. Lancet 2009;373:1532–42.</mixed-citation></citation-alternatives></ref><ref id="B57"><label>57.</label><citation-alternatives><mixed-citation xml:lang="en">58. Yan J., Wang S., Mi J.B. et al. Production and characterization of anti-recombinant human erythropoietin (rhEPO) monoclonal antibody. J Immunoassay Immunochem 2004;25(1):91–101.</mixed-citation><mixed-citation xml:lang="ru">Yan J., Wang S., Mi J.B. et al. Production and characterization of anti-recombinant human erythropoietin (rhEPO) monoclonal antibody. J Immunoassay Immunochem 2004;25(1):91–101.</mixed-citation></citation-alternatives></ref><ref id="B58"><label>58.</label><citation-alternatives><mixed-citation xml:lang="en">59. Лапчинская И.Н. Красноклеточная аплазия как осложнение терапии эритропоэтином: современное состояние проблемы. Укр журн гематологии и трансфузиологии 2004;3(4):45–7.</mixed-citation><mixed-citation xml:lang="ru">Лапчинская И.Н. Красноклеточная аплазия как осложнение терапии эритропоэтином: современное состояние проблемы. Укр журн гематологии и трансфузиологии 2004;3(4):45–7.</mixed-citation></citation-alternatives></ref><ref id="B59"><label>59.</label><citation-alternatives><mixed-citation xml:lang="en">60. Casadevall N., Nataf J., Viron B. Pure red-cell aplasia and antierythropoietin antibodies in patients with recombinant erythropoietin. N Engl J Med 2002; 246:469–75.</mixed-citation><mixed-citation xml:lang="ru">Casadevall N., Nataf J., Viron B. Pure red-cell aplasia and antierythropoietin antibodies in patients with recombinant erythropoietin. N Engl J Med 2002; 246:469–75.</mixed-citation></citation-alternatives></ref><ref id="B60"><label>60.</label><citation-alternatives><mixed-citation xml:lang="en">61. Захаров Ю.М. Цитопротективные функции эритропоэтина. Клин нефрол 2009;1:16–21.</mixed-citation><mixed-citation xml:lang="ru">Захаров Ю.М. Цитопротективные функции эритропоэтина. Клин нефрол 2009;1:16–21.</mixed-citation></citation-alternatives></ref><ref id="B61"><label>61.</label><citation-alternatives><mixed-citation xml:lang="en">62. Kumar S.M., Yu H., Fong D. et al. Erythropoietin activates the phosphoinositide 3-kinase/Akt pathway in human melanoma cells. Melanoma Res 2006;16(4):275–83.</mixed-citation><mixed-citation xml:lang="ru">Kumar S.M., Yu H., Fong D. et al. Erythropoietin activates the phosphoinositide 3-kinase/Akt pathway in human melanoma cells. Melanoma Res 2006;16(4):275–83.</mixed-citation></citation-alternatives></ref><ref id="B62"><label>62.</label><citation-alternatives><mixed-citation xml:lang="en">63. Ribatti D. Erythropoietin and tumor angiogenesis. Stem Cells Dev 2010;19(1):1–4.</mixed-citation><mixed-citation xml:lang="ru">Ribatti D. Erythropoietin and tumor angiogenesis. Stem Cells Dev 2010;19(1):1–4.</mixed-citation></citation-alternatives></ref><ref id="B63"><label>63.</label><citation-alternatives><mixed-citation xml:lang="en">64. Brines M.L., Ghezzi P., Keenan S. et al. Erythropoietin crosses the bloodbrain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 2000;97:10526–31.</mixed-citation><mixed-citation xml:lang="ru">Brines M.L., Ghezzi P., Keenan S. et al. Erythropoietin crosses the bloodbrain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 2000;97:10526–31.</mixed-citation></citation-alternatives></ref><ref id="B64"><label>64.</label><citation-alternatives><mixed-citation xml:lang="en">65. Westenbrink B.D., Lipsic E., van der Meer P. et al. Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor-mediated neovascularization. Eur Heart J 2007;28:2018–27.</mixed-citation><mixed-citation xml:lang="ru">Westenbrink B.D., Lipsic E., van der Meer P. et al. Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor-mediated neovascularization. Eur Heart J 2007;28:2018–27.</mixed-citation></citation-alternatives></ref><ref id="B65"><label>65.</label><citation-alternatives><mixed-citation xml:lang="en">66. Urao N., Okigaki M., Yamada H. rythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia. Circ Res 2006;98:1405–13.</mixed-citation><mixed-citation xml:lang="ru">Urao N., Okigaki M., Yamada H. rythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia. Circ Res 2006;98:1405–13.</mixed-citation></citation-alternatives></ref><ref id="B66"><label>66.</label><citation-alternatives><mixed-citation xml:lang="en">67. Sartelet H., Fabre M., Castaing M. et al. Expression of erythropoietin and its receptor in neuroblastomas. Cancer 2007;110(5):1096–106.</mixed-citation><mixed-citation xml:lang="ru">Sartelet H., Fabre M., Castaing M. et al. Expression of erythropoietin and its receptor in neuroblastomas. Cancer 2007;110(5):1096–106.</mixed-citation></citation-alternatives></ref><ref id="B67"><label>67.</label><citation-alternatives><mixed-citation xml:lang="en">68. Kumar S.M., Acs G., Fang D. et al. Functional erythropoietin autocrine loop in melanoma. Am J Pathol 2005;166(3):823–30.</mixed-citation><mixed-citation xml:lang="ru">Kumar S.M., Acs G., Fang D. et al. Functional erythropoietin autocrine loop in melanoma. Am J Pathol 2005;166(3):823–30.</mixed-citation></citation-alternatives></ref><ref id="B68"><label>68.</label><citation-alternatives><mixed-citation xml:lang="en">69. Acs G., Zhang P.J., McGrath C.M. et al. Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression. Am J Pathol 2003;162(6):1789–806.</mixed-citation><mixed-citation xml:lang="ru">Acs G., Zhang P.J., McGrath C.M. et al. Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression. Am J Pathol 2003;162(6):1789–806.</mixed-citation></citation-alternatives></ref><ref id="B69"><label>69.</label><citation-alternatives><mixed-citation xml:lang="en">70. Романенко Н.А., Бессмельцев С.С., Розанова О.Е. и др. Влияние уровня ФНО-альфа на эффективность коррекции анемии у больных лимфопролиферативными заболеваниями. Онкогематология 2010;3:22–8.</mixed-citation><mixed-citation xml:lang="ru">Романенко Н.А., Бессмельцев С.С., Розанова О.Е. и др. Влияние уровня ФНО-альфа на эффективность коррекции анемии у больных лимфопролиферативными заболеваниями. Онкогематология 2010;3:22–8.</mixed-citation></citation-alternatives></ref><ref id="B70"><label>70.</label><citation-alternatives><mixed-citation xml:lang="en">71. Steinbrook R. Medicare and erythropoietin. N Engl J Med; 356(1):4–6.</mixed-citation><mixed-citation xml:lang="ru">Steinbrook R. Medicare and erythropoietin. N Engl J Med; 356(1):4–6.</mixed-citation></citation-alternatives></ref><ref id="B71"><label>71.</label><citation-alternatives><mixed-citation xml:lang="en">72. Straus D.J. Epoetin alfa therapy for parameters with hematologic malignancies and mild anemia. Clin Lymphoma 2003;4(Suppl 1):13–7.</mixed-citation><mixed-citation xml:lang="ru">Straus D.J. Epoetin alfa therapy for parameters with hematologic malignancies and mild anemia. Clin Lymphoma 2003;4(Suppl 1):13–7.</mixed-citation></citation-alternatives></ref><ref id="B72"><label>72.</label><citation-alternatives><mixed-citation xml:lang="en">73. Ludwig H., Rai K., Blade J. et a l. Management of disease-related anemia in patients with multiple myeloma or chronic lymphocytic leukemia: epoetin treatment recommendations. Hematol J 2002;3(3):121–30.</mixed-citation><mixed-citation xml:lang="ru">Ludwig H., Rai K., Blade J. et a l. Management of disease-related anemia in patients with multiple myeloma or chronic lymphocytic leukemia: epoetin treatment recommendations. Hematol J 2002;3(3):121–30.</mixed-citation></citation-alternatives></ref><ref id="B73"><label>73.</label><citation-alternatives><mixed-citation xml:lang="en">74. Ludwig H., Fritz E., Kotzmann H. et al. Erythropoietin treatment of anemia associated with multiple myeloma. N Engl J Med 1990;322:1693–9.</mixed-citation><mixed-citation xml:lang="ru">Ludwig H., Fritz E., Kotzmann H. et al. Erythropoietin treatment of anemia associated with multiple myeloma. N Engl J Med 1990;322:1693–9.</mixed-citation></citation-alternatives></ref><ref id="B74"><label>74.</label><citation-alternatives><mixed-citation xml:lang="en">75. Musto P., Falcone A., D’Arena G. et al. Clinical results of recombinant human erythropoietin in transfusion-dependent patients with refractory multiple myeloma; role of cytokines and monitoring of erythropoiesis. Eur J Haematol 1997;58:314–9.</mixed-citation><mixed-citation xml:lang="ru">Musto P., Falcone A., D’Arena G. et al. Clinical results of recombinant human erythropoietin in transfusion-dependent patients with refractory multiple myeloma; role of cytokines and monitoring of erythropoiesis. Eur J Haematol 1997;58:314–9.</mixed-citation></citation-alternatives></ref><ref id="B75"><label>75.</label><citation-alternatives><mixed-citation xml:lang="en">76. Dammacco F., Silvestris F., Castoldi G.L. et al. The effectiveness and tolerability of epoetin alfa in patients with multiple myeloma refractory to chemotherapy. Int J Clin Lab Res 1998;28(2):127–34.</mixed-citation><mixed-citation xml:lang="ru">Dammacco F., Silvestris F., Castoldi G.L. et al. The effectiveness and tolerability of epoetin alfa in patients with multiple myeloma refractory to chemotherapy. Int J Clin Lab Res 1998;28(2):127–34.</mixed-citation></citation-alternatives></ref><ref id="B76"><label>76.</label><citation-alternatives><mixed-citation xml:lang="en">77. Dammacco F., Castoldi G., Rodjer S. Efficacy of epoetin alfa in treatmentof anemia of multiple myeloma. Br J Haematol 2001;113(1):172–9.</mixed-citation><mixed-citation xml:lang="ru">Dammacco F., Castoldi G., Rodjer S. Efficacy of epoetin alfa in treatmentof anemia of multiple myeloma. Br J Haematol 2001;113(1):172–9.</mixed-citation></citation-alternatives></ref><ref id="B77"><label>77.</label><citation-alternatives><mixed-citation xml:lang="en">78. Katodritou E., Terpos E., Zervas K. et al. Hypochromic erythrocytes ( %): a reliable marker for recognizing ironrestricted erythropoiesis and predicting response to erythropoietin in anemic patients with myeloma and lymphoma. Ann Hematol 2007;86(5):369–76.</mixed-citation><mixed-citation xml:lang="ru">Katodritou E., Terpos E., Zervas K. et al. Hypochromic erythrocytes ( %): a reliable marker for recognizing ironrestricted erythropoiesis and predicting response to erythropoietin in anemic patients with myeloma and lymphoma. Ann Hematol 2007;86(5):369–76.</mixed-citation></citation-alternatives></ref><ref id="B78"><label>78.</label><citation-alternatives><mixed-citation xml:lang="en">79. Glossmann J.P., Engert A., Wassmer G. et al. Recombinant human erythropoietin, epoetin beta, in patients with relapsed ymphoma treated with aggressive sequential salvage chemotherapy — results of a randomized trial. Ann Hematol 2003;82(8):469–75.</mixed-citation><mixed-citation xml:lang="ru">Glossmann J.P., Engert A., Wassmer G. et al. Recombinant human erythropoietin, epoetin beta, in patients with relapsed ymphoma treated with aggressive sequential salvage chemotherapy — results of a randomized trial. Ann Hematol 2003;82(8):469–75.</mixed-citation></citation-alternatives></ref><ref id="B79"><label>79.</label><citation-alternatives><mixed-citation xml:lang="en">80. Siakantaris M.P., Angelopoulou M.K., Vassilakopoulos T.P. et al. Correction of disease related anemia of B-chronic lymphoproliferative disorders by recombinant human erythropoietin: maintenance is necessary to sustain response. Leuk Lymphoma 2000; 40(1–2):141–7.</mixed-citation><mixed-citation xml:lang="ru">Siakantaris M.P., Angelopoulou M.K., Vassilakopoulos T.P. et al. Correction of disease related anemia of B-chronic lymphoproliferative disorders by recombinant human erythropoietin: maintenance is necessary to sustain response. Leuk Lymphoma 2000; 40(1–2):141–7.</mixed-citation></citation-alternatives></ref><ref id="B80"><label>80.</label><citation-alternatives><mixed-citation xml:lang="en">81. Osterborg A., Brandberg Y., Molostova V. et al. Randomized, doubleblind, placebo-controlled trial of recombinant human erythropoietin, epoetin Beta, in hematologic malignancies. J Clin Oncol 2002;20(10):2486–94.</mixed-citation><mixed-citation xml:lang="ru">Osterborg A., Brandberg Y., Molostova V. et al. Randomized, doubleblind, placebo-controlled trial of recombinant human erythropoietin, epoetin Beta, in hematologic malignancies. J Clin Oncol 2002;20(10):2486–94.</mixed-citation></citation-alternatives></ref><ref id="B81"><label>81.</label><citation-alternatives><mixed-citation xml:lang="en">82. Yang S., Jun M., Hong-Li Z. et al. A multi-center open-labeled study of recombinant erythropoietin-beta in the treatment of anemic patients with multiple myeloma, low-grade non-Hodgkin’s lymphoma, or chronic lymphocytic leukemia in Chinese population. Int J Hematol 2008;88(2):139–44.</mixed-citation><mixed-citation xml:lang="ru">Yang S., Jun M., Hong-Li Z. et al. A multi-center open-labeled study of recombinant erythropoietin-beta in the treatment of anemic patients with multiple myeloma, low-grade non-Hodgkin’s lymphoma, or chronic lymphocytic leukemia in Chinese population. Int J Hematol 2008;88(2):139–44.</mixed-citation></citation-alternatives></ref><ref id="B82"><label>82.</label><citation-alternatives><mixed-citation xml:lang="en">83. Straus D.J., Testa M.A., Sarokhan B.J. et al. Quality-of-life and health benefits of early treatment of mild anemia: a randomized trial of epoetin alfa in patients receiving chemotherapy for hematologic malignancies. Cancer 2006;107(8):1909–17.</mixed-citation><mixed-citation xml:lang="ru">Straus D.J., Testa M.A., Sarokhan B.J. et al. Quality-of-life and health benefits of early treatment of mild anemia: a randomized trial of epoetin alfa in patients receiving chemotherapy for hematologic malignancies. Cancer 2006;107(8):1909–17.</mixed-citation></citation-alternatives></ref><ref id="B83"><label>83.</label><citation-alternatives><mixed-citation xml:lang="en">84. Cazzola M., Beguin Y., Kloczko J. et al. Once-weekly epoetin beta is highly effective in treating anaemic patients with lymphoproliferative malignancy and defective endogenous erythropoietin Production. Br J Haematol 2003;122(3):386–93.</mixed-citation><mixed-citation xml:lang="ru">Cazzola M., Beguin Y., Kloczko J. et al. Once-weekly epoetin beta is highly effective in treating anaemic patients with lymphoproliferative malignancy and defective endogenous erythropoietin Production. Br J Haematol 2003;122(3):386–93.</mixed-citation></citation-alternatives></ref><ref id="B84"><label>84.</label><citation-alternatives><mixed-citation xml:lang="en">85. Osterborg A., Steegmann J.L., Hellmann A. Phase II study of three dose levels of continuous erythropoietin receptor activator (C.E.R.A.) in anaemic patients with aggressive non-Hodgkin’s lymphoma receiving combination chemotherapy. Br J Haematol 2007;136(5):736–44.</mixed-citation><mixed-citation xml:lang="ru">Osterborg A., Steegmann J.L., Hellmann A. Phase II study of three dose levels of continuous erythropoietin receptor activator (C.E.R.A.) in anaemic patients with aggressive non-Hodgkin’s lymphoma receiving combination chemotherapy. Br J Haematol 2007;136(5):736–44.</mixed-citation></citation-alternatives></ref><ref id="B85"><label>85.</label><citation-alternatives><mixed-citation xml:lang="en">86. Schmitt S., Mailaender V., Egerer G. et al. Successful autologous peripheral blood stem cell transplantation in a Jehovah’s Witness with multiple myeloma: review of literature and recommendations for high-dose chemotherapy without support of allogeneic blood products.</mixed-citation><mixed-citation xml:lang="ru">Schmitt S., Mailaender V., Egerer G. et al. Successful autologous peripheral blood stem cell transplantation in a Jehovah’s Witness with multiple myeloma: review of literature and recommendations for high-dose chemotherapy without support of allogeneic blood products.</mixed-citation></citation-alternatives></ref><ref id="B86"><label>86.</label><mixed-citation>Int J Hematol 2008;87(3):289–97.</mixed-citation></ref><ref id="B87"><label>87.</label><citation-alternatives><mixed-citation xml:lang="en">87. Baron F., Frère P., Fillet G., Beguin Y. Recombinant human erythropoietin therapy is very effective after an autologous peripheral blood stem cell transplant when started soon after engraftment.</mixed-citation><mixed-citation xml:lang="ru">Baron F., Frère P., Fillet G., Beguin Y. Recombinant human erythropoietin therapy is very effective after an autologous peripheral blood stem cell transplant when started soon after engraftment.</mixed-citation></citation-alternatives></ref><ref id="B88"><label>88.</label><mixed-citation>Clin Cancer Res 2003;9(15):5566–72.</mixed-citation></ref><ref id="B89"><label>89.</label><citation-alternatives><mixed-citation xml:lang="en">88. Martino M., Oliva E., Console G. et al. Administration of recombinant human erythropoietin alpha before autologous stem cell transplantation reduces transfusion requirement in multiple myeloma patients. Support Care Cancer 2005;13(3):182–7.</mixed-citation><mixed-citation xml:lang="ru">Martino M., Oliva E., Console G. et al. Administration of recombinant human erythropoietin alpha before autologous stem cell transplantation reduces transfusion requirement in multiple myeloma patients. Support Care Cancer 2005;13(3):182–7.</mixed-citation></citation-alternatives></ref><ref id="B90"><label>90.</label><citation-alternatives><mixed-citation xml:lang="en">89. Hunault-Berger M., Tanguy-Schmidt A., Rachieru P. et al. rHuEpo before high-dose therapy allows autologous peripheral stemcell transplantation without red blood cell transfusion: a pilot study. Bone Marrow Transplant 2005;35(9):903–7.</mixed-citation><mixed-citation xml:lang="ru">Hunault-Berger M., Tanguy-Schmidt A., Rachieru P. et al. rHuEpo before high-dose therapy allows autologous peripheral stemcell transplantation without red blood cell transfusion: a pilot study. Bone Marrow Transplant 2005;35(9):903–7.</mixed-citation></citation-alternatives></ref><ref id="B91"><label>91.</label><citation-alternatives><mixed-citation xml:lang="en">90. Olivieri A., Scortechini I., Capelli D . et al. Combined administration of alphaerythropoietin and filgrastim can improve the outcome and cost balance of autologous stem cell transplantation in patients with lymphoproliferative disorders. Bone Marrow Transplant 2004;34(8):693–702.</mixed-citation><mixed-citation xml:lang="ru">Olivieri A., Scortechini I., Capelli D . et al. Combined administration of alphaerythropoietin and filgrastim can improve the outcome and cost balance of autologous stem cell transplantation in patients with lymphoproliferative disorders. Bone Marrow Transplant 2004;34(8):693–702.</mixed-citation></citation-alternatives></ref><ref id="B92"><label>92.</label><citation-alternatives><mixed-citation xml:lang="en">91. Hart C., Grassinger J., Andreesen R., Hennemann B. EPO in combination with G-CSF improves mobilization effectiveness after chemotherapy with ifosfamide, epirubicin and etoposide and reduces costs during mobilization and transplantation of autologous hematopoietic progenitor</mixed-citation><mixed-citation xml:lang="ru">Hart C., Grassinger J., Andreesen R., Hennemann B. EPO in combination with G-CSF improves mobilization effectiveness after chemotherapy with ifosfamide, epirubicin and etoposide and reduces costs during mobilization and transplantation of autologous hematopoietic progenitor</mixed-citation></citation-alternatives></ref><ref id="B93"><label>93.</label><mixed-citation>cells. Bone Marrow Transplant 2009; 43(3):197–206.</mixed-citation></ref><ref id="B94"><label>94.</label><citation-alternatives><mixed-citation xml:lang="en">92. Beguin Y. Prediction of response to optimize outcome of treatment with erythropoietin. Semin Oncol 1998; 25(3 Suppl 7):27–34.</mixed-citation><mixed-citation xml:lang="ru">Beguin Y. Prediction of response to optimize outcome of treatment with erythropoietin. Semin Oncol 1998; 25(3 Suppl 7):27–34.</mixed-citation></citation-alternatives></ref><ref id="B95"><label>95.</label><citation-alternatives><mixed-citation xml:lang="en">93. Hedenus M., Birgegård G., Näsman P. et al. Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: a randomized multicenter study. Leukemia 2007;21(4):627–32.</mixed-citation><mixed-citation xml:lang="ru">Hedenus M., Birgegård G., Näsman P. et al. Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: a randomized multicenter study. Leukemia 2007;21(4):627–32.</mixed-citation></citation-alternatives></ref><ref id="B96"><label>96.</label><citation-alternatives><mixed-citation xml:lang="en">94. Katodritou E., Speletas M., Zervas K. et al. Evaluation of hypochromic erythrocytes in combination with sTfR-F index for predicting response to r -HuEPO in anemic patients with multiple myeloma. Lab Hematol 2006;12(1):47–54.</mixed-citation><mixed-citation xml:lang="ru">Katodritou E., Speletas M., Zervas K. et al. Evaluation of hypochromic erythrocytes in combination with sTfR-F index for predicting response to r -HuEPO in anemic patients with multiple myeloma. Lab Hematol 2006;12(1):47–54.</mixed-citation></citation-alternatives></ref><ref id="B97"><label>97.</label><citation-alternatives><mixed-citation xml:lang="en">95. Cazzola M., Messinger D., Battistel V. et al. Recombinant human erythropoietin in anemia associated with multiple myeloma or non-Hodgkin’s lymphoma: Dose finding and identification of predictors of respons. Blood 1995;86:4446–53.</mixed-citation><mixed-citation xml:lang="ru">Cazzola M., Messinger D., Battistel V. et al. Recombinant human erythropoietin in anemia associated with multiple myeloma or non-Hodgkin’s lymphoma: Dose finding and identification of predictors of respons. Blood 1995;86:4446–53.</mixed-citation></citation-alternatives></ref><ref id="B98"><label>98.</label><citation-alternatives><mixed-citation xml:lang="en">96. Cervantes F., Alvarez-Larrán A., Hernández-Boluda J.C. et al. Erythropoietin treatment of the anaemia of myelofibrosis with myeloid metaplasia: results in 20 patients and review of the literature. Br J Haematol 2004;127(4):399–403.</mixed-citation><mixed-citation xml:lang="ru">Cervantes F., Alvarez-Larrán A., Hernández-Boluda J.C. et al. Erythropoietin treatment of the anaemia of myelofibrosis with myeloid metaplasia: results in 20 patients and review of the literature. Br J Haematol 2004;127(4):399–403.</mixed-citation></citation-alternatives></ref><ref id="B99"><label>99.</label><citation-alternatives><mixed-citation xml:lang="en">97. Henry D.H. Clinical application of recombinant erythropoietin in anemic cancer patients. Hematol Oncol Clin North Am 1994;8(5):961–73.</mixed-citation><mixed-citation xml:lang="ru">Henry D.H. Clinical application of recombinant erythropoietin in anemic cancer patients. Hematol Oncol Clin North Am 1994;8(5):961–73.</mixed-citation></citation-alternatives></ref><ref id="B100"><label>100.</label><citation-alternatives><mixed-citation xml:lang="en">98. Ludwig H., Leitgeb C., Fritz E. e t al. Erythropoietin treatment of chronic anemia of cancer. Eur J Cancer 1993;29A(Suppl 2):8–12.</mixed-citation><mixed-citation xml:lang="ru">Ludwig H., Leitgeb C., Fritz E. e t al. Erythropoietin treatment of chronic anemia of cancer. Eur J Cancer 1993;29A(Suppl 2):8–12.</mixed-citation></citation-alternatives></ref><ref id="B101"><label>101.</label><citation-alternatives><mixed-citation xml:lang="en">99. Гусева С.А., Дарушин Е.В. и Гончаров Я.П. Коррекция анемии рекомбинантным эритропоэтиномальфа у больных миеломной болезнью. Укр журн гематологии и трансфузиологии 2003;5:11–6.</mixed-citation><mixed-citation xml:lang="ru">Гусева С.А., Дарушин Е.В. и Гончаров Я.П. Коррекция анемии рекомбинантным эритропоэтиномальфа у больных миеломной болезнью. Укр журн гематологии и трансфузиологии 2003;5:11–6.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
