OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press88310.17650/1818-8346-2023-18-4-233-243SUPPORTIVE THERAPY ASPECTSАСПЕКТЫ ПОДДЕРЖИВАЮЩЕЙ ТЕРАПИИGlucocorticosteroid-induced complications in patients with idiopathic thrombocytopenic purpuraОсложнения терапии глюкокортикостероидами у пациентов с идиопатической тромбоцитопенической пурпуройhttps://orcid.org/0000-0003-2847-4374ZakharovS. G.ЗахаровС. Г.
Russian Federation

Sergey G. Zakharov 

61/2 Shchepkina St., Moscow 129110

Сергей Геннадьевич Захаров

129110 Москва, ул. Щепкина, 61/2

hematologymoniki@mail.ruhttps://orcid.org/0000-0001-7493-0030MitinaT. A.МитинаТ. А.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0009-0008-0134-1049ZakharovaA. V.ЗахароваА. В.
Russian Federation

Build. 15, 6 Michurinskiy Prospekt, Moscow 119285

119285 Москва, Мичуринский пр-кт, 6, стр. 15

https://orcid.org/0000-0003-3842-4709VardanyanR. V.ВарданянР. В.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0000-0003-2650-7646KataevaE. V.КатаеваЕ. В.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0000-0002-7271-1560ChernykhYu. B.ЧерныхЮ. Б.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0000-0002-4604-2842VysotskayaL. L.ВысоцкаяЛ. Л.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0000-0002-5761-7891IvanitskiyL. V.ИваницкийЛ. В.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0000-0001-9337-6784KontievskiyI. N.КонтиевскийИ. Н.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0009-0007-6243-1884MadzyaraO. P.МадзяраО. П.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0000-0002-8457-2537ZhuravlevO. R.ЖуравлевО. Р.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0009-0006-4201-3071GorgunN. V.ГоргунН. В.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

https://orcid.org/0009-0005-5304-874XKharasovaZ. M.ХарасоваЗ. М.
Russian Federation

61/2 Shchepkina St., Moscow 129110

129110 Москва, ул. Щепкина, 61/2

M.F. Vladimirskiy Moscow Regional Research Clinical InstituteГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»United Hospital with Outpatient Department, Administrative Department of the President of the Russian FederationФГБУ «Объединенная больница с поликлиникой» Управления делами Президента Российской Федерации091220231842332430812202308122023https://oncohematology.abvpress.ru/ongm/article/view/883

Glucocorticosteroids (GCS) are the first-line treatment for idiopathic thrombocytopenic purpura (ITP). Despite their high efficacy in patients with newly diagnosed ITP, an adequate level of platelets remains after GCS withdrawal in only less than 20 % of patients. Additionally, GCS use is associated with an increased risk of different adverse reactions, including serious and life-threatening ones. Thrombopoietin receptor agonists represent a relatively new class of drugs for treating ITP as a second-line therapy. This paper reviews the risks of GCS pharmacotherapy, as well as the evidence supporting the use of thrombopoietin receptor agonists as both first-line and second-line treatment for patients with ITP.

Глюкокортикостероиды (ГКС) являются препаратами 1-й линии для лечения идиопатической тромбоцитопенической пурпуры (ИТП). Несмотря на высокую эффективность при назначении гкс пациентам с впервые диагностированной ИТП, только у менее 20 % после отмены препаратов сохраняется адекватный уровень тромбоцитов в крови. применение ГКС ассоциировано с высокой частотой развития различных нежелательных явлений, в том числе серьезных и жизнеугрожающих. Агонисты рецептора тромбопоэтина – относительно новый класс препаратов, предназначенных для лечения ИТП во 2-й линии. В данном обзоре подробно рассматриваются основные риски фармакотерапии гГКС, а также возможности применения различных агонистов рецептора тромбопоэтина в качестве терапии как 1-й, так и 2-й линии у пациентов с ИТП.

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