OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press8710.17650/1818-8346-2011-6-3-24-34HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯResults of candidemia treatment in children with hematologic malignancies: single center experienceРезультаты терапии кандидемии у детей с различными гематологическими и онкологическими заболеваниями в условиях одного центраKalininaI. I.КалининаИ. И.
Russian Federation
burbir@mail.ruBaydildinaD. D.БайдильдинаД. Д.
Russian Federation
SuntsovaE. V.СунцоваЕ. В.
Russian Federation
GoronkovaO. V.ГоронковаО. В.
Russian Federation
KhachatryanL. A.ХачатрянЛ. А.
Russian Federation
PetrovaU. N.ПетроваУ. Н.
Russian Federation
SolopovaG. G.СолоповаГ. Г.
Russian Federation
SinitsinaV. V.СиницынаВ. В.
Russian Federation
NovichkovaG. A.НовичковаГ. А.
Russian Federation
MaschanM. A.МасчанМ. А.
Russian Federation
LitvinovD. V.ЛитвиновД. В.
Russian Federation
MyakovaN. V.МяковаН. В.
Russian Federation
KlyasovaG. A.КлясоваГ. А.
Russian Federation
MaschanA. A.МасчанА. А.
Russian Federation
Federal Research Center of Children Hematology, Oncology and ImmunologyФГБУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздравсоцразвития РоссииRussian Children Clinical HospitalРоссийская детская клиническая больницаFederal Research Center of Children Hematology, Oncology and Immunology Russian Children Clinical HospitalФГБУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздравсоцразвития России Российская детская клиническая больницаRussian Hematological Research CenterГематологический научный центр РАМН2308201163243423072014230720142011https://oncohematology.abvpress.ru/ongm/article/view/87

Candidemia is one of the most serious infectious complications in children with hematological malignancies and has a high morta lity rate.Seven-year experience of candidemia diagnosis and therapy in patients with various hematologic malignancies w as analyzed. Candidemia registered in 37 patients (AML and MDS — 14, ALL — 10, solid tumors — 5, histocytic syndromes — 4, AA — 3, other non-malignancy diseases— 2). C. non-albicans (36 isolates from 32 patients) was common cause of, while C. albicans isolated in 5 patients (8 strains). Antifungal prophylactic therapy was applied to 31 patients. 22 patients at the time of candidemia have neutropenia (< 0.5 × 10 9/l). Main clinical manifestations were febrile fever (100 % cases) and pneumonia (21.6 % cases). Less frequent multiorgan failure (8.1 %), septic shoc k (5.4 %), chronic disseminated candidiasis (5.4 %) and meningitis (2.7 %) were registered. All patients received antifungal therapy (monotherapy — 17, combination therapy — 20). Central venous catheter removed in 21 patients. In 14 patients hematopoietic recovery w as registered, none of these patients died, while from group of patients without hematopoietic recovery 6 patients died (p = 0.0001). Recurrent candidemia episodes were seen in 4 patients. Overall survival was 0.37 ± 0.09.

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