OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press78410.17650/1818-8346-2009-0-4-33-44ФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯMesenchymal stem cells biological properties and possibilities of clinical useБиологические свойства и возможности клинического использования мезенхимальных стволовых клетокTatarinovaO. S.ТатариноваО. С.
Russian Federation

Moscow

Москва

OsipovaE. Yu.ОсиповаЕ. Ю.
Russian Federation

Moscow

Елена Юрьевна Осипова

Москва

e_ossipova@mail.ruRoumiantsevS. A.РумянцевС. А.
Russian Federation

Moscow

Москва

Lomonosov Moscow state universityМГУ им. М. В. ЛомоносоваFederal research center of pediatric hematology, oncology and immunologyФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии Минздравсоцразвития России281120094334428112022281120222009https://oncohematology.abvpress.ru/ongm/article/view/784

Autologic and allogeneic mesenchymal stem cells (MSC) transplantation currently is used in clinical practice for hematopoietic progenitor engraftment acceleration and graft versus host disease prophylactic and treatment. In this literature review data concerning efficacy, safety and technologies of MSC clinical use are analyzed. Biological properties of MSC received in long-term culture and mechanisms of their interaction with other cells are discussed.

Метод трансплантации мезенхимальных стволовых клеток (МСК), как аутологичных, так и аллогенных, в последние годы используется в клинической практике для ускорения приживления кроветворных предшественников и профилактики и терапии реакции «трансплантат против хозяина». В обзоре литературы проанализированы данные об эффективности, безопасности и технологических особенностях использования МСК в клинической практике. Обсуждаются биологические свойства МСК, полученных в результате длительного культивирования, и механизмы их взаимодействия с другими клеточными элементами.

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