OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press755HEMATOPOIETIC STEM CELL TRANSPLANTATIONТРАНСПЛАНТАЦИЯ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК У ПАЦИЕНТОВ С ГЕМОБЛАСТОЗАМИEpstein–Barr virus infection in patients after hematopoietic stem cells transplantationПроблема Эпштейна–Барр вирусной инфекции у пациентов после трансплантации гемопоэтических стволовых клетокBalashovD. N.БалашовД. Н.
Russian Federation

Moscow

Дмитрий Николаевич Балашов

ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии

Москва

bala8@yandex.ruShelikhovaL. N.ШелиховаЛ. Н.
Russian Federation

Moscow

ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии

Москва

DemushkinaA. A.ДемушкинаА. А.
Russian Federation

Moscow

Москва

TrakhtmanP. E.ТрахтманП. Е.
Russian Federation

Moscow

ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии

Москва

SkorobogatovaYe. V.СкоробогатоваЕ. В.
Russian Federation

Moscow

ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии

Москва

LitvinovD. V.ЛитвиновД. В.
Russian Federation

Moscow

ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии

Москва

RaykinaYe. V.РайкинаЕ. В.
Russian Federation

Moscow

ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии

Москва

MaschanA. A.МасчанА. А.
Russian Federation

Moscow

ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии

Москва

Federal Research Center of Pediatric Hematology, Oncology and ImmunologyМинздравсоцразвития РоссииRussian Children Clinical HospitalРоссийская детская клиническая больница260820103596426112022261120222010https://oncohematology.abvpress.ru/ongm/article/view/755

   Epstein–Barr virus (EBV) is a member of herpes-viruses family. Now it is well-known, that it can be a cause of wide spectrum lymphoproliferative disoders. The given problem is especially serious after hematopoietic stem cells transplantation (HSCT); frequency of death linked to this complication can achieve 50–90 %. Risk factors for development of posttransplant lymphoproliferative syndromes (PTLS) are: using partially compatible graft, T-cell depletion, presence of severe acute graft-versus-host reaction (GVHD), using of antitymocytic globulin, etc. Severity of associated with EBV posttransplant complications and problems relate to absence of clear diagnostic algorithm, PTLS prophylactic and therapy schedule are argument for necessity of the further studies.

   Эпштейна–Барр вирус (ЭБВ) является членом семейства герпес-вирусов. В настоящее время хорошо известно, что он может служить причиной широкого спектра лимфопролиферативных заболеваний. Данная проблема особенно серьезна в контексте пациентов после трансплантации гемопоэтических стволовых клеток. Частота летальных исходов, связанных с этим осложнением, может достигать 50–90 %. Факторами, компрометирующими развитие посттрансплантационныхлимфопролиферативных синдромов (ПТЛС), являются: применение парциально совместимого трансплантата, Т-клеточная деплеция, наличие у пациента тяжелой острой реакции «трансплантат против хозяина», использование антитимоцитарного глобулина и т. д. Тяжесть посттрансплантационных осложнений, ассоциированных с ЭБВ, а также ряд проблем, связанных с отсутствием четкого алгоритма проведения диагностики, профилактики и терапии ПТЛС – аргументы в пользу необходимости дальнейших исследований в данном направлении.

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