OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press753PHARMACOTHERAPYФАРМАКОТЕРАПИЯBendamustine: a new view on treatment of chronic lymphocytic leukemiaБендамустин: новый взгляд на лечение хронического лимфоцитарного лейкозаNikitinYe. A.НикитинЕ. А.
Russian Federation

Moscow

Евгений Александрович Никитин

Гематологический научный центр

Москва

eugene_nikitin@mail.ruHematological Scientific CenterРАМН260820103465126112022261120222010https://oncohematology.abvpress.ru/ongm/article/view/753

   Chronic lymphocytic leukemia (CLL) is the most frequent leukemia type in adults. Despite significant achievements in therapy of this disease in young adults, treatment of elderly patients represents the problem, first of all, because of the unsatisfactory acceptability of the regimens containing purine analogues. The new drug – ribomustin – combining properties of alkylating agents and purine analogues is registered in 2010 in Russia. The major advantage of ribomustin is its low toxicity. In several researches it is shown, that ribomustin is effective both in relapse and as front line therapy in CLL patients. Results of clinical studies of ribomustin in CLL patients are discussed in the given review.

   Хронический лимфолейкоз (ХЛЛ) – самый частый вид лейкозов у взрослых. Несмотря на значительные достижения в терапии этого заболевания у молодых пациентов, лечение пожилых больных представляет большую проблему, прежде всего из-за неудовлетворительной переносимости режимов, содержащих пуриновые аналоги. В 2010 г. в России зарегистрирован новый препарат рибомустин, сочетающий в себе свойства алкилирующих соединений и аналогов пуринов. Большое преимущество рибомустина состоит в его низкой токсичности. В нескольких исследованиях показано, что рибомустин эффективен как в ситуации рецидива, так и в терапии 1-й линии больных ХЛЛ. В данном обзоре рассматриваются результаты клинических испытаний рибомустина у больных ХЛЛ.

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