OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press74210.17650/1818-8346-2009-0-2-61-89HEMATOPOIETIC STEM CELL TRANSPLANTATIONТРАНСПЛАНТАЦИЯ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОКSexual development and gonads function in children and adolescents after allogeneic stem cell transplantation using different conditioning regimesПоловое развитие и функция гонад у детей и подростков после аллогенной трансплантации гемопоэтических стволовых клеток с использованием различных режимов кондиционированияPapushaL. I.ПапушаЛ. И.
Russian Federation

Moscow

Людмила Ивановна Папуша

Москва

ludmila.mur@mail.ruBalashovD. N.БалашовД. Н.
Russian Federation

Moscow

Москва

Tul'pakovA. N.ТюльпаковА. Н.
Russian Federation

Moscow

Москва

SkorobogatovaE. V.СкоробогатоваЕ. В.
Russian Federation

Moscow

Москва

KurnikovaE. E.КурниковаЕ. Е.
Russian Federation

Moscow

Москва

SkvortsovaY. V.СкворцоваЮ. В.
Russian Federation

Moscow

Москва

MaschanA. A.МасчанА. А.
Russian Federation

Moscow

Москва

Federal Research Center of Pediatric Hematology, Oncology and ImmunologyФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии РосздраваRussian Children Clinical HospitalФГУ Российская детская клиническая больницаEndocrinology Research CenterФГУ Эндокринологический научный центр РАМН270520092616925112022251120222009https://oncohematology.abvpress.ru/ongm/article/view/742

Various conditioning regimes influence on sexual development and gonads function in children and adolescent after stem cell transplantation was studied. 45 patients were enrolled in the study: 23 patients with aplastic anemia (АА), who received non-myeloablative conditioning, and 22 patients with acute myeloid leukemia (AML) after myeloablative conditioning. Sexual development was estimated by Tanner classification, laboratory tests included gonadotropic hormones, sex steroids, antiMullerian hormone and inhibin B level detection. It has been shown that non-myeloablative conditioning does not influence sexual development in any patients. Extremely high frequency of gonads lesion in patients received myeloablative conditioning was registered: hypergonadotrophic hypogonadism in 8 from 12 girls with severe decrease of ovaries functional reserve in all patients; germinal epithelium lesion in 9 from 10 boys.

Исследование посвящено изучению влияния различных режимов кондиционирования на половое развитие и функцию гонад у детей и подростков после трансплантации гематологических стволовых клеток. В исследование было включено 45 больных: 23 пациента с апластической анемией, получивших немиелоаблативное кондиционирование, и 22 – с острым миелобластным лейкозом, развившимся после миелоаблативного кондиционирования. Клиническую оценку полового развития проводили на основании классификации Таннера, лабораторные анализы включали определение уровней гонадотропинов, половых стероидов, антимюллерова гормона и ингибина В. В результате показано, что немиелоаблативные режимы кондиционирования не оказывали негативного воздействия на половое развитие ни у одного из пациентов. У больных, получивших миелоаблативное кондиционирование, зарегистрирована чрезвычайно высокая частота поражения гонад: гипергонадотропный гипогонадизм – у 8 из 12 девочек на фоне резкого снижения функционального резерва яичников у всех пациенток; поражение герминативного эпителия – у 9 из 10 мальчиков.

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