OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press7410.17650/1818-8346-2012-7-4-35-42HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯInfections caused by rare mold fungi in hematologyИнфекции, вызванные редкими плесневыми грибами, в гематологииKalininaI. I.КалининаИ. И.
Russian Federation
burbir@mail.ruPetrovaU. N.ПетроваУ. Н.
Russian Federation
GoronkovaO. V.ГоронковаО. В.
Russian Federation
BaidildinaD. D.БайдильдинаД. Д.
Russian Federation
SinitsynaV. V.СиницынаВ. В.
Russian Federation
KhachatryanL. A.ХачатрянЛ. А.
Russian Federation
MaschanM. A.МасчанМ. А.
Russian Federation
KlyasovaG. A.КлясоваГ. А.
Russian Federation
MaschanA. A.МасчанА. А.
Russian Federation
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Ministry of Health of RussiaФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииRussian Hematological Research Center, Ministry of Health of RussiaФГБУ ГНЦ Минздрава России2311201274354223072014230720142012https://oncohematology.abvpress.ru/ongm/article/view/74

Worldwide distribution of mold fungi and their extremely danger for immune compromise patients makes this issue one of the unsolved problems in modern oncology. Three cases of rare fungal infections in children with hematological malignancies are described. In the first case infection caused by Acremonium spp. in AML patients was controlled after voriconazole therapy and granulocytes recovery. The second patients with aplastic anemia died as a result of invasive fungal infection caused by Fusarium spp. despite of combined antifungal therapy and granulocytes transfusions. In the third case diagnosis of Mucor mycosis was made only at autopsy

Повсеместное распространение плесневых грибов и их смертельная опасность для иммунокомпроментированных больных делает данную проблему до настоящего времени одной из нерешенных в онкогематологии. В статье представлено описание 3 случаев развития редких плесневых грибковых инфекций у детей с онкогематологическими заболеваниями. Первый случай – девочка с острым миелобластным лейкозом и развитием Acremonium spp., данный инфекционный эпизод был купирован при применении антимикотической терапии вориконазолом и восстановлении уровня гранулоцитов. У второго пациента с апластической анемией развился инвазивный микоз, вызванный Fusarium spp.; несмотря на проводимую комбинированную противогрибковую терапию и трансфузии донорских гранулоцитов, данная инфекция привела к смерти пациента. В третьем случае у больного с Mucor spp. диагноз был установлен только на аутопсии.

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