OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press72310.17650/1818-8346-2008-0-3-34-44HEMATOPOIETIC STEM CELL TRANSPLANTATIONТРАНСПЛАНТАЦИЯ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОКPrognostic factors of the efficiency of obtaining the autologous precursor cells of hemopoiesis for further transplantation after large-dose chemotherapy: review of literature and the authors' dataФакторы прогноза эффективности получения аутологичных клеток-предшественников гемопоэза для последующей трансплантации после высокодозной химиотерапии. Обзор литературы и собственные данныеPopovA. Yu.ПоповА. Ю.
Russian Federation
ZhukovN. N.ЖуковН. Н.
Russian Federation
MinenkoS. V.МиненкоС. В.
Russian Federation
AndreyevaL. Yu.АндрееваЛ. Ю.
Russian Federation
PtushkinV. V.ПтушкинВ. В.
Russian Federation
Department of Adolescent and Age-Related Clinical Oncology, Federal Research Clinical Centre of Pediatric Hematology, Oncology and ImmunologyОтделение подростковой и возрастной клинической онкологии ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии240820083344424112022241120222008https://oncohematology.abvpress.ru/ongm/article/view/723

To obtain a sufficient number of hemopoietic progenitor cells (HPCs) for a rapid and stable recovery of hematopoiesis is one of the major conditions for safe high-dose chemotherapy. The paper analyses the current approaches to mobilizing and collecting HPCs, as well as the factors influencing their efficiency. By using their own large material (264 patients who had undergone mobilizing procedures), the authors have shown that none of predictors (age, a history of multiple courses of chemotherapy, peripheral blood levels of CD34+ cells at sampling, etc.) may identify patients in whom peripheral blood HPCs cannot be certainly ineffectively collected. At the same time, combined mobilization with myelostimulating factors (granulocyte, granulocytemacrophage colony-stimulating factors) and cytostatics (high-dose cyclophosphamide) yield the greatest quantities of HPCs from peripheral blood in patients with solid tumors and multiple myeloma.

Получение достаточного для быстрого и стабильного восстановления кроветворения числа клеток-предшественников гемопоэза (КПГ) является одним из основных условий безопасного проведения высокодозной химиотерапии. В статье приведен анализ существующих подходов к мобилизации и сбору КПГ, факторов, влияющих на их эффективность. На значительном собственном материале (264 пациента, прошедших процедуры мобилизации) показано, что ни один из факторов прогноза (возраст, множественные курсы химиотерапии в анамнезе, содержание CD34+ клеток в периферической крови в момент сбора и т.д.) не позволяет выявить больных с заведомо неэффективным сбором КПГ периферической крови. В то же время комбинированная мобилизация с использованием миелостимулирующих факторов (гранулоцитарный, гранулоцитарно-макрофагальный колониестимулирующие факторы) и цитостатиков (высокие дозы циклофосфамида) у больных с солидными опухолями и множественной миеломой позволяет получить наибольшее число КПГ из периферической крови.

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