OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press7110.17650/1818-8346-2012-7-4-11-15NEW TRENDS IN MEDICAL SCIENCEНОВЫЕ НАПРАВЛЕНИЯ МЕДИЦИНСКОЙ НАУКИFullerene and oxidative stressФуллерены и оксидативный стрессOrlovaM. A.ОрловаМ. А.
Russian Federation

Химический факультет, кафедра радиохимии

orlova.radiochem@mail.ruTrofimovaT. P.ТрофимоваТ. П.
Russian Federation

Химический факультет, кафедра радиохимии

OrlovA. P.ОрловА. П.
Russian Federation

медико-биологический факультет, кафедра медицинских нанобиотехнологий

ShatalovO. A.ШаталовО. А.
Russian Federation

фармацевтический факультет, кафедра фармакологии

SvistunovA. A.СвистуновА. А.
Russian Federation

фармацевтический факультет, кафедра фармакологии

NapolovYu. K.НаполовЮ. К.
Russian Federation

фармацевтический факультет, кафедра фармакологии

ChekhoninV. P.ЧехонинВ. П.
Russian Federation

медико-биологический факультет, кафедра медицинских нанобиотехнологий

M.V. Lomonosov Moscow State UniversityФГБОУ ВПО «Московский государственный университет им. М.В. Ломоносова»N.I. Pirogov Russian National Research Medical UniversityГБОУ ВПО «Российский научно-исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииI.M. Sechenov Moscow State Medical UniversityГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России2311201274111523072014230720142012https://oncohematology.abvpress.ru/ongm/article/view/71

Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immediately and long-term consequences of their effects in vivo which is a true obstacle on the way leading to their practical medical using. First, this concerns their impact on the proliferation, apoptosis and necrosis regulation. Fullerene nanoparticle functionalization type, their sizes and surface nanopathology are of great importance for further promoting of either cytoprotective or cytotoxic effects. One of the main effects of fullerenes on living systems is the reactive oxygen species (ROS) formation induction. This lecture provides a modern concept analysis regarding fullerenes effects on ROS formation and modulation of proliferation and apoptosis in normal and tumor cells.

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