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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">698</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2008-0-1-2-75-84</article-id><article-categories><subj-group subj-group-type="toc-heading"><subject>НОВЫЕ ПРЕПАРАТЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Pegylated liposomal doxorubicin (Caelyx): contemporary aspects of its application in hematology</article-title><trans-title-group xml:lang="ru"><trans-title>Современные возможности применения пегилированного липосомального доксорубицина (келикс) в гематологии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rukavitsin</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Рукавицын</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pop</surname><given-names>V. P.</given-names></name><name xml:lang="ru"><surname>Поп</surname><given-names>В. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>Главный военный клинический госпиталь им. акад. Н.Н. Бурденко</institution></aff><content-language>ru</content-language><pub-date date-type="pub" publication-format="electronic" iso-8601-date="2008-05-23"><day>23</day><month>05</month><year>2008</year></pub-date><pub-date date-type="collection"><year>2008</year></pub-date><issue>1-2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>75</fpage><lpage>84</lpage><history><date date-type="received" iso-8601-date="2022-11-23"><day>23</day><month>11</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-11-23"><day>23</day><month>11</month><year>2022</year></date></history><pub-history><event event-type="received"><event-desc>Received:<date date-type="received" iso-8601-date="2022-11-23"><day>23</day><month>11</month><year>2022</year></date></event-desc></event><event event-type="accepted"><event-desc>Accepted:<date date-type="accepted" iso-8601-date="2022-11-23"><day>23</day><month>11</month><year>2022</year></date></event-desc></event><event event-type="pub"><event-desc>Published:<pub-date date-type="pub" publication-format="electronic" iso-8601-date="2008-05-23"><day>23</day><month>05</month><year>2008</year></pub-date></event-desc></event></pub-history><permissions><copyright-year>2008</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/698">https://oncohematology.abvpress.ru/ongm/article/view/698</self-uri><abstract xml:lang="en"><p>.</p></abstract><trans-abstract xml:lang="ru"><p>.</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Ferrans V.J. Overview of cardiac pathology in relation to anthracycline cardiac toxicity. Canc Treat Rep 1978;62:955—61.</mixed-citation><mixed-citation xml:lang="ru">Ferrans V.J. Overview of cardiac pathology in relation to anthracycline cardiac toxicity. Canc Treat Rep 1978;62:955—61.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Ewer M.S., Benjamin R.S. Cardiotoxicity of chemotherapeutic Drugs. In: The Chemotherapy source book. Ed. M.C. Perry. 1997. p. 649—63.</mixed-citation><mixed-citation xml:lang="ru">Ewer M.S., Benjamin R.S. Cardiotoxicity of chemotherapeutic Drugs. In: The Chemotherapy source book. Ed. M.C. Perry. 1997. p. 649—63.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Olson R.D., Mushlin P.S., Breuner D.E. et al. Doxorubicin cardiotoxicity may be due to its metabolite, doxorubicinol. Proc Natl acad Sci USA 1988;85:3585—9.</mixed-citation><mixed-citation xml:lang="ru">Olson R.D., Mushlin P.S., Breuner D.E. et al. Doxorubicin cardiotoxicity may be due to its metabolite, doxorubicinol. Proc Natl acad Sci USA 1988;85:3585—9.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Slamon D.J., Leyland-Jones B., Shak S. et al. Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2. N Engl J Med 2001;344:783—92.</mixed-citation><mixed-citation xml:lang="ru">Slamon D.J., Leyland-Jones B., Shak S. et al. Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2. N Engl J Med 2001;344:783—92.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Singal P.K., Iliskovic N. Doxorubicin-Induced Cardiomyopathy. N Engl J Med 1998;339:900—5.</mixed-citation><mixed-citation xml:lang="ru">Singal P.K., Iliskovic N. Doxorubicin-Induced Cardiomyopathy. N Engl J Med 1998;339:900—5.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Lasic D.D., Papahadjopoulos D. Liposomes revisited. Science 1995;267:1275—6.</mixed-citation><mixed-citation xml:lang="ru">Lasic D.D., Papahadjopoulos D. Liposomes revisited. Science 1995;267:1275—6.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Harrington K.L., Lewanski C.R., Stewart S.W. Liposomes as vehicles for targeted therapy of cancer/Part.2: Clinical development. Clin Oncol 2000;12:16—24.</mixed-citation><mixed-citation xml:lang="ru">Harrington K.L., Lewanski C.R., Stewart S.W. Liposomes as vehicles for targeted therapy of cancer/Part.2: Clinical development. Clin Oncol 2000;12:16—24.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Allen T.M., Martin F.J. Advantages of liposomal delivery systems for anthracyclines. Semin Oncol 2004;31(Suppl 13):5—15.</mixed-citation><mixed-citation xml:lang="ru">Allen T.M., Martin F.J. Advantages of liposomal delivery systems for anthracyclines. Semin Oncol 2004;31(Suppl 13):5—15.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. O'Brien M.E.R., Wigler N., Inbar M. et al. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCI (Caelyx/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann Oncol 2004;5(3):440—9.</mixed-citation><mixed-citation xml:lang="ru">O'Brien M.E.R., Wigler N., Inbar M. et al. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCI (Caelyx/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann Oncol 2004;5(3):440—9.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Gabizon A., Catane R., Uziely B. Prolonged circulation time and enhansed accumulation in malignant exudates of doxorubicin encapsulated in polyethyleneglycol coated liposomes. Canser Res 1994;54:987—92.</mixed-citation><mixed-citation xml:lang="ru">Gabizon A., Catane R., Uziely B. Prolonged circulation time and enhansed accumulation in malignant exudates of doxorubicin encapsulated in polyethyleneglycol coated liposomes. Canser Res 1994;54:987—92.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Theodoulou M., Hudis C. Cardiac profiles of liposomal anthracyclines. Greater cardiac safety versus conventional doxorubicin? Cancer 2004;100(10):2052—63.</mixed-citation><mixed-citation xml:lang="ru">Theodoulou M., Hudis C. Cardiac profiles of liposomal anthracyclines. Greater cardiac safety versus conventional doxorubicin? Cancer 2004;100(10):2052—63.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Wingler N., O'Brien M., Rosso R. et al. Reduced cardiotoxicity and comparable efficacy in phase III trial of pegylated liposomal doxorubicin (Caelyx/Doxil) vs. doxorubicin for first-line treatment of metastatic breast cancer. Proc ASCO 2002;21:1; s. 45a, N177.</mixed-citation><mixed-citation xml:lang="ru">Wingler N., O'Brien M., Rosso R. et al. Reduced cardiotoxicity and comparable efficacy in phase III trial of pegylated liposomal doxorubicin (Caelyx/Doxil) vs. doxorubicin for first-line treatment of metastatic breast cancer. Proc ASCO 2002;21:1; s. 45a, N177.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Lotem M., Hubert A., Lyass O. et al. Skin toxic effects of polyethylene glycolcoated liposomal doxorubicin. Arch Dermatol 2000;136:1475—80.</mixed-citation><mixed-citation xml:lang="ru">Lotem M., Hubert A., Lyass O. et al. Skin toxic effects of polyethylene glycolcoated liposomal doxorubicin. Arch Dermatol 2000;136:1475—80.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Alberts D.S., Garcia D.J. A safety review of pegylated liposomal doxorubicin in the treatment of various malignancies. Oncology 1997; Suppl 11:54—62.</mixed-citation><mixed-citation xml:lang="ru">Alberts D.S., Garcia D.J. A safety review of pegylated liposomal doxorubicin in the treatment of various malignancies. Oncology 1997; Suppl 11:54—62.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Szelenyi H., Siehl J., Menssen H.D. et al. Cyclophosphamide, liposomal doxorubicin and dexamethasone (CLAD) is safe and efficacious in multiple myeloma. Eur J Cancer 1999;35(Supp l4):337—44.</mixed-citation><mixed-citation xml:lang="ru">Szelenyi H., Siehl J., Menssen H.D. et al. Cyclophosphamide, liposomal doxorubicin and dexamethasone (CLAD) is safe and efficacious in multiple myeloma. Eur J Cancer 1999;35(Supp l4):337—44.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Dingeldein G.C., Hoffmann M., Huebner G. et al. Phase I/II study with liposomal-encapsulated doxorubicin in VAD-protocol for patients with multiple myeloma. Blood 2001;98:308b (abstr 4985).</mixed-citation><mixed-citation xml:lang="ru">Dingeldein G.C., Hoffmann M., Huebner G. et al. Phase I/II study with liposomal-encapsulated doxorubicin in VAD-protocol for patients with multiple myeloma. Blood 2001;98:308b (abstr 4985).</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Bartlett N., Niedzwiecki D., Johnson J. et al. A phase I/II study of gemcitabine, vinorelbine, and liposomal doxorubicin for relapsed Hodgkin's disease: Preliminary results of CALGB 59804. Proc Am Soc Clin Oncol 2003;22:566 (abstr 2275).</mixed-citation><mixed-citation xml:lang="ru">Bartlett N., Niedzwiecki D., Johnson J. et al. A phase I/II study of gemcitabine, vinorelbine, and liposomal doxorubicin for relapsed Hodgkin's disease: Preliminary results of CALGB 59804. Proc Am Soc Clin Oncol 2003;22:566 (abstr 2275).</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Bastion Y., Blay J.Y., Divine M. et al. Elderly patients with aggressive non- Hodgkin's lymphoma: disease presentation, response to treatment, and survival - a groupe d' Etude des Lymphomes de l' Adulte study on 453 patients older than 69 years. J Clin Oncol 1997;15:2945—53.</mixed-citation><mixed-citation xml:lang="ru">Bastion Y., Blay J.Y., Divine M. et al. Elderly patients with aggressive non- Hodgkin's lymphoma: disease presentation, response to treatment, and survival - a groupe d' Etude des Lymphomes de l' Adulte study on 453 patients older than 69 years. J Clin Oncol 1997;15:2945—53.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Niitsu N., Iijima K. Full-dose CHOP chemotherapy combined with granulocyte colony-stimulating factor for aggressive non-Hodgkin's lymphoma in elderly patients: a prospective study. Ann Hematol 2001;80:602—6.</mixed-citation><mixed-citation xml:lang="ru">Niitsu N., Iijima K. Full-dose CHOP chemotherapy combined with granulocyte colony-stimulating factor for aggressive non-Hodgkin's lymphoma in elderly patients: a prospective study. Ann Hematol 2001;80:602—6.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Ewer M.S., Martin F.J., Henderson I.C. et al. Cardiac safety of liposomal anthracyclines. Semin Oncol 2004;31 (Suppl 13):161—81.</mixed-citation><mixed-citation xml:lang="ru">Ewer M.S., Martin F.J., Henderson I.C. et al. Cardiac safety of liposomal anthracyclines. Semin Oncol 2004;31 (Suppl 13):161—81.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Martino R., Perea G., Caballero M.D. et al. Cyclophosphamide, pegylated liposomal doxorubicin (Caelyx), vincristine and prednisone (CCOP) in elderly patients with diffuse large B-cell lymphoma: Results from a prospective phase II study. Haematologica 2002;87:822—7.</mixed-citation><mixed-citation xml:lang="ru">Martino R., Perea G., Caballero M.D. et al. Cyclophosphamide, pegylated liposomal doxorubicin (Caelyx), vincristine and prednisone (CCOP) in elderly patients with diffuse large B-cell lymphoma: Results from a prospective phase II study. Haematologica 2002;87:822—7.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Topilow A.A., Mencel P.J., Nahum K. et al. Cyclophosphamide/pegylated liposomal doxorubicin/vincristine/prednisone (CDOP) in the treatment of intermediate grade non-Hodgkin's lymphoma (IGNHL): A five-year follow-up. Proc Am Soc Clin Oncol 2003;22:596 (abstr 2397).</mixed-citation><mixed-citation xml:lang="ru">Topilow A.A., Mencel P.J., Nahum K. et al. Cyclophosphamide/pegylated liposomal doxorubicin/vincristine/prednisone (CDOP) in the treatment of intermediate grade non-Hodgkin's lymphoma (IGNHL): A five-year follow-up. Proc Am Soc Clin Oncol 2003;22:596 (abstr 2397).</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Tsavaris N., Kosmas C., Vadiaka M. et al. Pegylated liposomal doxorubicin in the CHOP regimen for older patients with aggressive (stages III/IV) non-Hodgkin's lymphoma. Anticancer Res 2002;22:1845—8.</mixed-citation><mixed-citation xml:lang="ru">Tsavaris N., Kosmas C., Vadiaka M. et al. Pegylated liposomal doxorubicin in the CHOP regimen for older patients with aggressive (stages III/IV) non-Hodgkin's lymphoma. Anticancer Res 2002;22:1845—8.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Zaja F., Tomadini V., Zaccaria A. et al. CHOP-rituximab with pegylated liposomal doxorubicin for the treatment of elderly patients with diffuse large B-cell lymphoma. Leuk Lymphoma 2006;47(10):2174—80.</mixed-citation><mixed-citation xml:lang="ru">Zaja F., Tomadini V., Zaccaria A. et al. CHOP-rituximab with pegylated liposomal doxorubicin for the treatment of elderly patients with diffuse large B-cell lymphoma. Leuk Lymphoma 2006;47(10):2174—80.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Bartlett N., Niedzwiecki D., Johnson J. et al. Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen in relapsed Hodgkin's lymphoma: CALGB 59804. Ann Oncol 2007;18:1071—9.</mixed-citation><mixed-citation xml:lang="ru">Bartlett N., Niedzwiecki D., Johnson J. et al. Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen in relapsed Hodgkin's lymphoma: CALGB 59804. Ann Oncol 2007;18:1071—9.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Wollina U., Graefe T., Kaatz M. Pegylated doxorubicin for primary cutaneous T-cell lymphoma: a report on ten patient with follow-up. J Cancer Res Clin Oncol 2001;127:128—34.</mixed-citation><mixed-citation xml:lang="ru">Wollina U., Graefe T., Kaatz M. Pegylated doxorubicin for primary cutaneous T-cell lymphoma: a report on ten patient with follow-up. J Cancer Res Clin Oncol 2001;127:128—34.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Wollina U., Dummer R., Brockmeyer N.H. et al. Multicenter study of pegylated liposomal doxorubicin in patients with cutaneous T-cell lymphoma. Cancer 2003;98:993—1001.</mixed-citation><mixed-citation xml:lang="ru">Wollina U., Dummer R., Brockmeyer N.H. et al. Multicenter study of pegylated liposomal doxorubicin in patients with cutaneous T-cell lymphoma. Cancer 2003;98:993—1001.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">28. Pulini S., Rupoli S., Goteri G. et al. Pegylated liposomal doxorubicin in the treatment of primary cutaneous T-cell lymphomas. Haematologica 2007;92:686—9.</mixed-citation><mixed-citation xml:lang="ru">Pulini S., Rupoli S., Goteri G. et al. Pegylated liposomal doxorubicin in the treatment of primary cutaneous T-cell lymphomas. Haematologica 2007;92:686—9.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">29. Di Bella N.J., Khan M.M., Dakhil S.R. et al. Pegylated liposomal doxorubicin as single-agent treatment of low-grade non-Hodgkin's lymphoma: A phase II multicenter study. Clin Lymphoma 2003;3:235—40.</mixed-citation><mixed-citation xml:lang="ru">Di Bella N.J., Khan M.M., Dakhil S.R. et al. Pegylated liposomal doxorubicin as single-agent treatment of low-grade non-Hodgkin's lymphoma: A phase II multicenter study. Clin Lymphoma 2003;3:235—40.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">30. Macpherson N., Belch A., Taylor M. et al. Liposomal encapsulated doxorubicin (Caelyx) in the treatment of relapsed aggressive non-Hodgkin's lymphoma: A phase II study. Leuk Lymphoma 2006;47(7):1327—32.</mixed-citation><mixed-citation xml:lang="ru">Macpherson N., Belch A., Taylor M. et al. Liposomal encapsulated doxorubicin (Caelyx) in the treatment of relapsed aggressive non-Hodgkin's lymphoma: A phase II study. Leuk Lymphoma 2006;47(7):1327—32.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">31. Tulpule A., Khan A.U., Mohrbacher A.F. et al. A phase II trial of pegylated liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone (DR-COP) in aggressive Bcell non-Hodgkin's lymphoma. Proc Am Soc Clin Oncol 2004;23:602 (abstr 6688).</mixed-citation><mixed-citation xml:lang="ru">Tulpule A., Khan A.U., Mohrbacher A.F. et al. A phase II trial of pegylated liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone (DR-COP) in aggressive Bcell non-Hodgkin's lymphoma. Proc Am Soc Clin Oncol 2004;23:602 (abstr 6688).</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">32. Vacca A., Ribatti D., Roncali L. et al. Bone marrow angiogenesis and progression in multiple myeloma. Br J Haematol 1994;87:503—8.</mixed-citation><mixed-citation xml:lang="ru">Vacca A., Ribatti D., Roncali L. et al. Bone marrow angiogenesis and progression in multiple myeloma. Br J Haematol 1994;87:503—8.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">33. He X.S., Srkalovic G., Hsi E.D. et al. The effects of different chemotherapeutic regimens on bone marrow microvessel density in patients with multiple myeloma [abstract 2424]. Proc Am Soc Clin Oncol 2003;22:603.</mixed-citation><mixed-citation xml:lang="ru">He X.S., Srkalovic G., Hsi E.D. et al. The effects of different chemotherapeutic regimens on bone marrow microvessel density in patients with multiple myeloma [abstract 2424]. Proc Am Soc Clin Oncol 2003;22:603.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">34. Dimopoulos M.A., Pouli A., Zervas K. et al. Prospective randomized comparison of vincristine, doxorubicin and dexamethasone (VAD) administered as intravenous bolus injection and VAD with liposomal doxorubicin as first-line treatment in multiple myeloma. Ann Oncol 2003;14:1039—44.</mixed-citation><mixed-citation xml:lang="ru">Dimopoulos M.A., Pouli A., Zervas K. et al. Prospective randomized comparison of vincristine, doxorubicin and dexamethasone (VAD) administered as intravenous bolus injection and VAD with liposomal doxorubicin as first-line treatment in multiple myeloma. Ann Oncol 2003;14:1039—44.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">35. Hussein M.A., Rifkin R., Gregory S.A. et al. DVd versus VAd in the treatment of patients with newly diagnosed multiple myeloma (n-MM): An update from a randomized multicenter trial. Blood 2003;102:453a (abstr 1653).</mixed-citation><mixed-citation xml:lang="ru">Hussein M.A., Rifkin R., Gregory S.A. et al. DVd versus VAd in the treatment of patients with newly diagnosed multiple myeloma (n-MM): An update from a randomized multicenter trial. Blood 2003;102:453a (abstr 1653).</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">36. Rifkin R.M.., Gregory S.A., Mohrbacher A., Hussein M.A. Pegylated Liposomal Doxorubicin, Vincristine, and Dexamethasone Provide Significant Reduction in Toxicity Compared with Doxorubicin, Vincristine, and Dexamethasone in Patients with Newly Diagnosed Multiple Myeloma. A Phase III Multicenter Randomized Trial. Cancer 2006;106:848—58.</mixed-citation><mixed-citation xml:lang="ru">Rifkin R.M.., Gregory S.A., Mohrbacher A., Hussein M.A. Pegylated Liposomal Doxorubicin, Vincristine, and Dexamethasone Provide Significant Reduction in Toxicity Compared with Doxorubicin, Vincristine, and Dexamethasone in Patients with Newly Diagnosed Multiple Myeloma. A Phase III Multicenter Randomized Trial. Cancer 2006;106:848—58.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">37. Hussein M.A., Wildgust M., Fastenau J. et al. Cost effectiveness of DVd vs VAd in newly diagnosed multiple myeloma. Proc Am Soc Clin Oncol 2004;23:567 (abstr 6548).</mixed-citation><mixed-citation xml:lang="ru">Hussein M.A., Wildgust M., Fastenau J. et al. Cost effectiveness of DVd vs VAd in newly diagnosed multiple myeloma. Proc Am Soc Clin Oncol 2004;23:567 (abstr 6548).</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">38. Agrawal N., Hussein M.A., Elson P. et al. Pegylated doxorubicin, vincristine, reduced frequency dexamethasone and thalidomide (DVd-T) in newly diagnosed and relapsed/refractory multiple myeloma patients. Blood 2003;102:237a (abstr 831).</mixed-citation><mixed-citation xml:lang="ru">Agrawal N., Hussein M.A., Elson P. et al. Pegylated doxorubicin, vincristine, reduced frequency dexamethasone and thalidomide (DVd-T) in newly diagnosed and relapsed/refractory multiple myeloma patients. Blood 2003;102:237a (abstr 831).</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">39. Zervas K., Dimopoulos M.A., Hatziharisi E. et al: Primary treatment of multiple myeloma with thalidomide, vincristine, liposomal doxorubicin and dexamethasone (T-VAD Doxil): A phase II multicenter study. Ann Oncol 2004;15:138.</mixed-citation><mixed-citation xml:lang="ru">Zervas K., Dimopoulos M.A., Hatziharisi E. et al: Primary treatment of multiple myeloma with thalidomide, vincristine, liposomal doxorubicin and dexamethasone (T-VAD Doxil): A phase II multicenter study. Ann Oncol 2004;15:138.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">40. Rossi J.-F., Jourdan E., Legouffe E. et al: Intermediate analysis of a prospective randomised comparison of standard VAD protocol (vincristine, doxorubicin and dexamethasone) and pegylated liposomal doxorubicin (Doxil/CAELYX) plus dexamethasone as a first-line treatment in multiple myeloma (MM). Blood 2003;102:447a (abstr 1631).</mixed-citation><mixed-citation xml:lang="ru">Rossi J.-F., Jourdan E., Legouffe E. et al: Intermediate analysis of a prospective randomised comparison of standard VAD protocol (vincristine, doxorubicin and dexamethasone) and pegylated liposomal doxorubicin (Doxil/CAELYX) plus dexamethasone as a first-line treatment in multiple myeloma (MM). Blood 2003;102:447a (abstr 1631).</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">41. Orlowski R.Z., Voorhees P.M., Garcia R.A. et al. Phase I study of the proteasome inhibitor bortezomib in combination with pegylated liposomal doxorubicin in patients with refractory hematologic malignancies. Blood 2003;102:449a (abstr 1639).</mixed-citation><mixed-citation xml:lang="ru">Orlowski R.Z., Voorhees P.M., Garcia R.A. et al. Phase I study of the proteasome inhibitor bortezomib in combination with pegylated liposomal doxorubicin in patients with refractory hematologic malignancies. Blood 2003;102:449a (abstr 1639).</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">42. Baz R., Walker E., Karam M.A. et al. Lenalidomide and pegylated liposomal doxorubicinbased chemotherapy for relapsed or refractory multiple myeloma: safety and efficacy. Ann Oncol 2006;17:1766—71.</mixed-citation><mixed-citation xml:lang="ru">Baz R., Walker E., Karam M.A. et al. Lenalidomide and pegylated liposomal doxorubicinbased chemotherapy for relapsed or refractory multiple myeloma: safety and efficacy. Ann Oncol 2006;17:1766—71.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">43. Orlowski R.Z.., Nagler A., Sonneveld P. et al. Randomized Phase III Study of Pegylated Liposomal Doxorubicin Plus Bortezomib Compared With Bortezomib Alone in Relapsed or Refractory Multiple Myeloma: Combination Therapy Improves Time to Progression. J Clin Oncol 2007;25:3892—901.</mixed-citation><mixed-citation xml:lang="ru">Orlowski R.Z.., Nagler A., Sonneveld P. et al. Randomized Phase III Study of Pegylated Liposomal Doxorubicin Plus Bortezomib Compared With Bortezomib Alone in Relapsed or Refractory Multiple Myeloma: Combination Therapy Improves Time to Progression. J Clin Oncol 2007;25:3892—901.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">44. Hussein M.A., Anderson K.C. Role of Liposomal Anthracyclines in the Treatment of Multiple Myeloma. Semin Oncol 2004;31(Suppl 13):147—60.</mixed-citation><mixed-citation xml:lang="ru">Hussein M.A., Anderson K.C. Role of Liposomal Anthracyclines in the Treatment of Multiple Myeloma. Semin Oncol 2004;31(Suppl 13):147—60.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">45. Lopes de Menezes D.E., Pilarski L.M., Belch A.R., Alien T.M. Selective targeting of immunoliposomal doxorobicin against human multiple myeloma in vitro and ex vivo. Biochim Biophys Acta 2000;1466(1—2):205—20.</mixed-citation><mixed-citation xml:lang="ru">Lopes de Menezes D.E., Pilarski L.M., Belch A.R., Alien T.M. Selective targeting of immunoliposomal doxorobicin against human multiple myeloma in vitro and ex vivo. Biochim Biophys Acta 2000;1466(1—2):205—20.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">46. Lundberg B.B., Griffiths G., Hansen H.J. Specific binding of sterically stabilized anti-B-cell immunoliposomes and cytotoxicity of entrapped doxorubicin. Int J Pharm 2000;205(1—2):101—8.</mixed-citation><mixed-citation xml:lang="ru">Lundberg B.B., Griffiths G., Hansen H.J. Specific binding of sterically stabilized anti-B-cell immunoliposomes and cytotoxicity of entrapped doxorubicin. Int J Pharm 2000;205(1—2):101—8.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
