OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press6810.17650/1818-8346-2012-7-1-35-45BASIC RESEARCHФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ПРАКТИЧЕСКОЙ МЕДИЦИНЕ НА СОВРЕМЕННОМ ЭТАПЕUmbilical cord bloods hematopoietic stem cells ex vivo expansion (the literature review)Ex vivo экспансия гемопоэтических стволовых клеток пуповинной крови (обзор литературы)ShamanskayaT. V.ШаманскаяТ. В.
Russian Federation
totti111@list.ruOsipovaE. Yu.ОсиповаЕ. Ю.
Russian Federation
RoumiantsevS. A.РумянцевС. А.
Russian Federation
Dmitiry Rogachev Federal Research Center of Pediatric Hematology, Oncology and ImmunologyФГБУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздравсоцразвития России2202201271354522072014220720142012https://oncohematology.abvpress.ru/ongm/article/view/68

Umbilical cord blood (CB) is now an attractive source of hematopoietic stem cells (HSCs) for transplantation in pediatric and adult patients with various malignant and non-malignant diseases. However, its clinical application is limited by low cells numbers in graft, which correlates with delayed engraftment, an extension of time to platelets and neutrophils recovery and increasing risk of infectious complications. Several strategies have been suggested to overcome this limitation, one of which is obtaining a sufficient number of hematopoietic progenitor cells by ex vivo expansion. Literature review about CB HSCs expansion in given article is presented.

Пуповинная кровь (ПК) в настоящее время является привлекательным источником гемопоэтических стволовых клеток (ГСК) для трансплантации в детской практике и у взрослых пациентов с различными злокачественными и незлокачественными заболеваниями. Однако ее применение в клинике ограничено низким количеством клеток в трансплантате, что коррелирует с отсроченным приживлением, удлинением времени до восстановления тромбоцитов и нейтрофилов, развитием инфекционных осложнений. Для решения этой проблемы было предпринято несколько попыток, одна из которых – получение достаточного количества гемопоэтических клеток-предшественников путем ex vivo экспансии. В данной статье проведен обзор литературы, посвященный особенностям экспансии ГСК ПК.

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