OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press67910.17650/1818-8346-2008-0-1-2-39-46HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯComparison of efficacy and toxicity of FC and FCR regimens in primary B-cell chronic lymphocytic leukemia: a retrospective studyРетроспективное сравнение эффективности и токсичности режимов лечения FC и FCR у первичных больных В-клеточным хроническим лимфолейкозомStadnikYe. А.СтадникЕ. А.
Russian Federation

Санкт-Петербург

NikitinYe. А.НикитинЕ. А.
Russian Federation

Москва

BidermanB. V.БидерманБ. В.
Russian Federation

Москва

SalogubG. N.СалогубГ. Н.
Russian Federation

Санкт-Петербург

LorieYu. Yu.ЛориеЮ. Ю.
Russian Federation

Москва

TsybaN. N.ЦыбаН. Н.
Russian Federation

Москва

AlexeevaYu. A.AлексееваЮ. А.
Russian Federation

Санкт-Петербург

DoroninV. A.ДоронинВ. А.
Russian Federation

Москва

MashukV. N.МащукВ. Н.
Russian Federation

Краснодар

VabishevichR. I.ВабищевичР. И.
Russian Federation

Санкт-Петербург

MelikyanA. L.МеликянА. Л.
Russian Federation

Москва

KolosheinovaT. I.КолошейноваТ. И.
Russian Federation

Москва

KolosovaL. Yu.КолосоваЛ. Ю.
Russian Federation

Москва

SudarikovA. B.СудариковА. Б.
Russian Federation

Москва

KovalevaL. G.КовалеваЛ. Г.
Russian Federation

Москва

ZaritskyA. Yu.ЗарицкийА. Ю.
Russian Federation

Санкт-Петербург

Городская клиническая больница №31ГУ «Гематологический научный центр» РАМНЦентральная клиническая больница №2 Министерства путей сообщенияКраснодарский краевой онкодиспансерФедеральный центр крови, сердца и эндокринологии им. акад. В.А. Алмазова230520081-2394623112022231120222008https://oncohematology.abvpress.ru/ongm/article/view/679

Preclinical studies showed synergic anti-tumor activity of Rituximab and Fludarabin. Comparison of efficacy of FC with FCR regimens administered in first line therapy and their influence on disease-free and overall survival in patients with B-cell lymphocytic leukemia were the main goals of this retrospective study. It has been demonstrated that inclusion of Rituximab into the FC regimen improves outcome of patients with B-cell lymphocytic leukemia without significant increase of toxicity.

В доклинических исследованиях показана синергичная противоопухолевая активность ритуксимаба и флударабина. В ретроспективном исследовании проведено сравнение эффективности режимов FC и FCR , применявшихся в качестве первой линии терапии В-ХЛЛ, по длительности ответа, беспрогрессивной и общей выживаемости у первичных больных В-ХЛЛ. Показано, что добавление ритуксимаба к режиму FC у первичных больных В-ХЛЛ улучшает результаты лечения без существенного увеличения токсичности.

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