OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press67210.17650/1818-8346-2007-0-4-36-46THERAPY OF HEMATOLOGIC MALIGNANCIESТЕРАПИЯ ГЕМОБЛАСТОЗОВThe treatment of patients with local stages I, II, IE, IIE of Hodgkin's lymphoma: medical radiological research center experienceЛечение больных лимфомой Ходжкина с локальными стадиями I, II, Ie, IIe: опыт медицинского радиологического научного центраShakhtarinaS. V.ШахтаринаС. В.
Russian Federation

Obninsk

Обнинск

PavlovV. V.ПавловВ. В.
Russian Federation

Obninsk

Обнинск

DanilenkoA. A.ДаниленкоА. А.
Russian Federation

Obninsk

Обнинск

AfanasovaN. V.АфанасоваН. В.
Russian Federation

Obninsk

Обнинск

Medical Radiological research Center, RAMSМедицинский радиологический научный центр, РАМН231120074364623112022231120222007https://oncohematology.abvpress.ru/ongm/article/view/672

In this article we present results of radiotherapy and combined modality treatment of 1882previously untreated patients with Hodgkin s lymphoma (HL) stages I, II, Ie, IIe at MRRC RAMS (Obninsk) between 1968 and 2006. Frequency and types of second malignancies, female fertility are presented too. 25-years overall survival rate was 59,1%, disease-specific survival — 73,2%, freedom from treatment failure — 46,8% after the radical program of radiotherapy. These rates in female patients with HL stages IA, IIA and histological subtype nodular sclerosis resulted 86,5%, 93,7%, 82,2% respectively. 20-years overall survival rate was 80,7%, disease-specific survival — 85,1%, freedom from treatment failure — 81,1% after combined modality treatment. In favorable prognosis group 36-month overall survival was 100% with no recurrences after 6 cycles of chemotherapy COPP followed by radiotherapy in total doses of20—24Gy. In intermediate prognosis group overall and disease-specific survival were 97,1%, freedom from treatment failure survival — 84,1% after 6—8 cycles ABVD followed by involved field radiotherapy in total doses 36Gy.

Представлены результаты лечения 1882 первичных больных лимфомой Ходжкина (ЛХ) I,II,Ie,IIe стадий, получавших лучевую и полихимиолучевую терапию в МРНЦРАМН (Обнинск) с 1968по 2006г., данные о частоте и характере вторых злокачественных опухолей, детородной функции женщин. 25-летняя выживаемость больных ЛХ, получивших лучевую терапию по радикальной программе, составила: общая — 59,1%, зависящая от заболевания — 73,2%, свободная от неудач лечения — 46,8%, у женщин ЛХ IA, IIA стадий с гистологическим вариантом «узелковый склероз» — 86,5, 93,7и 82,2% соответственно. 20-летняя выживаемость больных ЛХ, получивших полихимиотерапию (ПХТ) по схеме СОРР и облучение в СОД 36— 40 Гр, составила: общая — 80,7%, зависящая от заболевания — 85,1%, свободная от неудач лечения — 81,1%. При применении шести циклов ПХТ СОРР и лучевой терапии в СОД20—24Гр 36-месячная выживаемость в группе больных ЛХ с благоприятным прогнозом — 100%, рецидивов не было. В группе больных ЛХ с промежуточным прогнозом, получивших 6—8 циклов ПХТ ABVD и лучевую терапию очагов поражения в СОД 36Гр, 36-месячная общая выживаемость и выживаемость, зависящая от заболевания, составили 97,1%, выживаемость, свободная от неудач лечения, — 84,1%.

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