OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press66810.17650/1818-8346-2007-0-4-12-16BIOLOGY OF HEMATOLOGIC MALIGNANCIESБИОЛОГИЯ ГЕМОБЛАСТОЗОВPeculiar age distribution of cytogenetic abnormalities in acute myeloid leukemiaВозрастные особенности цитогенетических изменений при острых миелоидных лейкозахFleischmanE. W.ФлейшманЕ. В.
Russian Federation

Moscow

Москва

SokovaO. I.СоковаО. И.
Russian Federation

Moscow

Москва

PopaA. V.ПопаА. В.
Russian Federation

Moscow

Москва

KirichenkoO. P.КириченкоО. П.
Russian Federation

Moscow

Москва

KonstantinovaL. N.КонстантиноваЛ. Н.
Russian Federation

Moscow

Москва

MetelkovaN. F.МетельковаН. Ф.
Russian Federation

Moscow

Москва

Russian Cancer Research Center, Russian Academy of Medical SciencesГУ РОНЦ им. Н.Н. Блохина, РАМН231120074121623112022231120222007https://oncohematology.abvpress.ru/ongm/article/view/668

Peculiar age distribution of clinically significant recurring chromosome abnormalities was found as a result of investigation of526AML patients (249 children and 277 adults). Thus t(8;21) was more frequently detected in age from 2 to 10 years, t(15;17) was extremely rare in children under 5 years, rearrangements of 11q23 region were observed in more than half of patients under 24 months, inv(16) was most characteristic for patients in age 16-20 years; patients who were older than 51 years have showed a comparatively high incidence of normal karyotype (no chromosome abnormalities).

There were defined some chromosome characteristics of AML observed in children in age under 24 months. No patients with normal karyotype and chromosome translocations t(8;21) and t(15;17) associated with good risk were detected, but 11q23 rearrangements and complex karyotype were found significantly more frequent than in older children and adults.

Cytogenetic features of AML in different age groups with their hematopoietic peculiarities can be useful for clarification of mechanisms of specific chromosome abnormalities origin.

Своеобразное возрастное распределение частоты клинически значимых аномалий кариотипа обнаружено при цитогенетическом обследовании 526 (249 детей и 277 взрослых) больных острым миелоидным лейкозом (ОМЛ). Так, t(8;21) наиболее часто наблюдалась у пациентов в возрасте от 2 до 10 лет; t(15;17) крайне редко выявлялась у детей до 5 лет; хромосомные перестройки, затрагивающие район 11q23, встречались почти в половине случаев у детей до 24 мес; inv(16) была наиболее характерна для пациентов 16—20 лет; у лиц старше 51 года наблюдалась повышенная частота случаев без хромосомных аномалий (нормальный кариотип). Отмечены цитогенетические особенности группы самых младших пациентов с ОМЛ (от 0 до 24 мес): в ней не было обнаружено ни одного случая с нормальным кариотипом и транслокациями t(8;21) и t(15;17), ассоциированными с хорошим ответом на терапию; при этом чаще, чем у старших детей и взрослых, выявлялись перестройки хромосомного района 11q23, а также сложные аномалии кариотипа. Данные о цитогенетическом своеобразии ОМЛ в разных возрастных группах и особенностях кроветворения в том или ином возрасте в дальнейшем могут оказаться полезными для расшифровки механизмов возникновения специфических изменений кариотипа при этом заболевании.

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