OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press623HEMATOLOGIC MALIGNANCIES: TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯBiological basis of immunomodulatory preparations using in treatment of multiple myelomaБиологические основы применения иммуномодулирующих препаратов в лечении множественной миеломыSemochkinS. V.СемочкинС. В.
Russian Federation

Moscow

Сергей Вячеславович Семочкин

ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии

Москва

s.semochkin@gmail.comFederal Research Center of Pediatric Hematology, Oncology and ImmunologyМинздравсоцразвития России230220101213122112022221120222010https://oncohematology.abvpress.ru/ongm/article/view/623

   Immunomodulatory preparations (IMP) — lenalidomide (СС-5013, Revlimid®) and pomlidomide (CC-4047, Actimid®) — a new class of the medical products which are thalidomide synthetic derivatives. In comparison with initial compound they possess higher therapeutic activity and the optimized profile of toxic complications. In this review modern data on IMP antitumor activity with reference to multiple myeloma therapy are presented. Results of clinical study of lenalidomide in first-line therapy, in relapsed/refractory multiple myeloma and as a maintenance therapy after transplantation are shown.

   Иммуномодулирующие препараты (ИМП) леналидомид (СС-5013, Ревлимид®) и помалидомид (CC-4047, Актимид®) — новый класс лекарственных средств, являющихся синтетическими производными талидомида. По сравнению с исходным соединением они обладают более высокой терапевтической активностью и оптимизированным профилем токсических осложнений. В обзоре представлены современные сведения по разносторонним механизмам противоопухолевого действия ИМП применительно к лечению множественной миеломы (ММ). Освещены результаты завершенных и текущих клинических исследований по применению леналидомида в схемах 1-й линии, при рецидивах/рефрактерной ММ, а также в качестве поддерживающей терапии после трансплантационных технологий.

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