OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press61910.17650/1818-8346-2007-0-2-59-62COMPLICATIONS OF HEMATOLOGIC MALIGNANCIES AND THEIR TREATMENTОСЛОЖНЕНИЯ ГЕМОБЛАСТОЗОВ И ИХ ЛЕЧЕНИЕHypercalcemia associated with hematologic malignanciesСиндром гиперкальциемии при онкогематологических заболеванияхKurmukovI. A.КурмуковИ. А.
Russian Federation

Москва

KashiaSh. R.КашияШ. Р.
Russian Federation

Москва

Отделение реанимации и интенсивной терапии № 5 (терапевтическое) РОНЦ им. Н.Н. Блохина РАМН230520072596222112022221120222007https://oncohematology.abvpress.ru/ongm/article/view/619

Гиперкальциемия, развившаяся на фоне онкологического заболевания, значительно ухудшает непосредственный прогноз: около половины пациентов с клинически значимой гиперкальциемией умирают в течение 1 мес [1], при этом степень выраженности гиперкальциемии и ее симптомов вовсе не свидетельствует об инкурабельности самого онкологического заболевания.

hypercalcemiaгиперкальциемиясимптомылечениебисфосфонатыгемофильтрация1. Ralston S.H., Gallagher S.J., Patel U. et al. Cancer-associated hypercalcemia: morbidity and mortality: clinical experience in 126 treated patients. Ann Intern Med 1990;112:499—504.Ralston S.H., Gallagher S.J., Patel U. et al. Cancer-associated hypercalcemia: morbidity and mortality: clinical experience in 126 treated patients. Ann Intern Med 1990;112:499—504.2. John R., Oleesky D., Issa B. et al. Pseudohypercalcaemia in two patients with IgM paraproteinaemia. Ann Clin Biochem 1997; 34:694—6.John R., Oleesky D., Issa B. et al. Pseudohypercalcaemia in two patients with IgM paraproteinaemia. Ann Clin Biochem 1997; 34:694—6.3. Stewart A.F. Hypercalcemia Associated with Cancer. N Engl J Med 2005;352:373—9.Stewart A.F. Hypercalcemia Associated with Cancer. N Engl J Med 2005;352:373—9.4. Bilezikian J.P., Silverberg S.J. Asymptomatic primary hyperparathyroidism. N Engl J Med 2004;350: 1746—51.Bilezikian J.P., Silverberg S.J. Asymptomatic primary hyperparathyroidism. N Engl J Med 2004;350: 1746—51.5. LeBoff M.S., Mikulec K.H. Hypercalcemia: clinical manifestations, pathogenesis, diagnosis, and management. In: M.J. Favus (eds.). Primer on the metabolic bone diseases and disorders of mineral metabolism. 5th ed. Washington D.C., American Society for Bone and Mineral Research; 2003. p. 225—30.LeBoff M.S., Mikulec K.H. Hypercalcemia: clinical manifestations, pathogenesis, diagnosis, and management. In: M.J. Favus (eds.). Primer on the metabolic bone diseases and disorders of mineral metabolism. 5th ed. Washington D.C., American Society for Bone and Mineral Research; 2003. p. 225—30.6. Fleisch H. Bisphosphonates: mechanisms of action. Endocr Rev 1998;19:80—100.Fleisch H. Bisphosphonates: mechanisms of action. Endocr Rev 1998;19:80—100.7. Markowitz G.S., Fine P.L., Stack J.I. et al. Toxic acute tubular necrosis following treatment with zoledronate (Zometa). Kidney Int 2003;64:281—9.Markowitz G.S., Fine P.L., Stack J.I. et al. Toxic acute tubular necrosis following treatment with zoledronate (Zometa). Kidney Int 2003;64:281—9.8. Pecherstorfer M., Steinhauer E.U., Rizzoli R. et al. Efficacy and safety of ibandronate in the treatment of hypercalcemia of malignancy: a randomized multicentric comparison to pamidronate. Support Care Cancer 2003;11:539—47.Pecherstorfer M., Steinhauer E.U., Rizzoli R. et al. Efficacy and safety of ibandronate in the treatment of hypercalcemia of malignancy: a randomized multicentric comparison to pamidronate. Support Care Cancer 2003;11:539—47.9. von Moos R. Bisphosphonate Treatment Recommendations for Oncologists. The Oncologist 2005;10 (Suppl 1):19—24.von Moos R. Bisphosphonate Treatment Recommendations for Oncologists. The Oncologist 2005;10 (Suppl 1):19—24.10. Binstock M.L., Mundy G.R. Effect of calcitonin and glucocorticoids in combination on the hypercalcemia of malignancy. Ann Intern Med 1980;93:269—72.Binstock M.L., Mundy G.R. Effect of calcitonin and glucocorticoids in combination on the hypercalcemia of malignancy. Ann Intern Med 1980;93:269—72.11. Koo W.S., Jeon D.S., Ahn S.J. et al. Calcium-free hemodialysis for the management of hypercalcemia. Nephron 1996;72:424—8.Koo W.S., Jeon D.S., Ahn S.J. et al. Calcium-free hemodialysis for the management of hypercalcemia. Nephron 1996;72:424—8.