OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press604HEMATOLOGIC MALIGNANCIES: TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯChronic myeloid leukemia — before and after imatinib (Third part)Хронический миелолейкоз — до и после иматиниба (часть III)LomaiaE. G.ЛомаиаЕ. Г.
Russian Federation

St-Petersburg

Санкт-Петербург

KonoplevaM. Yu.КоноплеваМ. Ю.
Russian Federation

St-Petersburg

Санкт-Петербург

RomanovaE. G.РомановаЕ Г.
Russian Federation

St-Petersburg

Екатерина Геннадьевна Романова

Санкт-Петербург

katrin51297@mail.ruZaritzkiyA. Yu.ЗарицкийА. Ю.
Russian Federation

St-Petersburg

Санкт-Петербург

Federal Almazov hearth, blood and endocrinology CentreФГУ Федеральный центр сердца, крови и эндокринологии им. В. А. Алмазова23022010152022112022221120222010https://oncohematology.abvpress.ru/ongm/article/view/604

   Imatinib (IM) appearance has changed approaches to chronic myeloid leukemia (CML) therapy. Second generation tyrosine kinase inhibitors (TKI) — nilotinib and dasatinib, developed soon after IM, and are already widely used in CML patients with inefficiency or intolerance of them. Considering availability in clinical practice of tree TKI, allogeneic hematopoietic stem cell transplantation (HSCT) and new preparations development, there is a real treatment of all patients with CML, which was recently considered as fatal disease. In first two parts of article general information about CML, issues concerning HSCT, TKI mechanisms of action and safety are discussed. In this part TKI therapy efficacy and modern treatment recommendation for CML patients in different phases are presented.

   Появление иматиниба (ИМ) кардинально изменило подходы к терапии хронического миелолейкоза (ХМЛ). Ингибиторы тирозинкиназ (ИТК) второго поколения — нилотиниб и дазатиниб, разработанные вскоре после ИМ, – уже нашли широкое применение у больных ХМЛ с неэффективностью или непереносимостью ИМ. Наличие в рутинной медицинской практике трех ИТК, аллогенная трансплантация гемопоэтических стволовых клеток (алло-ТГСК), а также разработка большого числа новых препаратов делают вполне реальным излечение всех пациентов с ХМЛ, до недавнего времени считавшимся фатальным заболеванием. В первых 2 частях статьи содержались общие сведения о ХМЛ, подробно были освещены вопросы по алло-ТГСК, приводились данные по механизму действия ИТК и их безопасности. Последняя часть статьи посвящена эффективности терапии ИТК и современным рекомендациям по ведению пациентов с ХМЛ в разных фазах болезни.

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