OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press58810.17650/1818-8346-2022-17-4-48-59HEMATOLOGIC MALIGNANCIES: TREATMENTЛЕЧЕНИЕ ГЕМОБЛАСТОЗОВKikuchi–Fujimoto disease: literature review and report of four casesБолезнь Кикучи–Фуджимото: обзор литературы и четыре клинических наблюденияhttps://orcid.org/0000-0003-2985-0503PotapenkoV. G.ПотапенкоВ. Г.
Russian Federation

Prospekt Dinamo, Saint Petersburg 197110

197110 Санкт-Петербург, пр-кт Динамо, 3

https://orcid.org/0000-0002-9191-5091BaykovV. V.БайковВ. В.
Russian Federation

12 Rentgena St., Saint Petersburg 197022

197022 Санкт-Петербург, ул. Рентгена, 12

MarkovaА. Yu.МарковаА. Ю.
Russian Federation

1 Bolnichnaya St., Kapustin Yar 416510

416510 Капустин Яр, ул. Больничная, 1

https://orcid.org/0000-0002-8153-8122MikhailovaN. B.МихайловаН. Б.
Russian Federation

12 Rentgena St., Saint Petersburg 197022

197022 Санкт-Петербург, ул. Рентгена, 12

Ter‑GrigoryanA. S.Тер-ГригорянА. С.
Armenia

7 Grachya Nersisyana St., Yerevan 0014

0014, Ереван, ул. Грачья Нерсисяна, 7

https://orcid.org/0000-0002-9872-0326KrivolapovYu. А.КриволаповЮ. А.
Russian Federation

41 Kirochnaya St., Saint Petersburg 191015

191015 Санкт-Петербург, ул. Кирочная, 41

City Clinical Hospital No. 31СПб ГБУЗ «Городская клиническая больница № 31»Raisa Gorbacheva Memorial Research Institute for Pediatric Oncology, Hematology and Transplantation, I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaНИИ детской онкологии, гематологии и трансплантологии им. Р.М. Горбачевой ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииCity Hospital of the closed territorial unit ZnamenskГБУЗ АО «Городская больница ЗАТО Знаменск»Hematological Center named after professor R.O. Yeolyan, Ministry of Health of the Republic of ArmeniaАОЗТ «Гематологический центр им. проф. Р.О. Еоляна» Mинздрава Республики АрменияI.I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России0711202217448590611202206112022https://oncohematology.abvpress.ru/ongm/article/view/588

Kikuchi–Fujimoto disease, or necrotizing histiocytic lymphadenitis, is one of the rare causes of benign lymphadeno-pathy. The diagnosis is based on histological and immunohistochemical analysis of the lymph node biopsy. The article presents four clinical cases of Kikuchi–Fujimoto disease. According to the results of the primary analysis of lymph node tissue three patients were misdiagnosed with lymphoma. due to the unusual for lymphoid malignancy course the primary material was reviewed. The diagnosis of Kikuchi–Fujimoto disease was put. In three patients the disease has a re-current course. during the observation period, the course of the disease in all the presented patients is benign with normal quality of life.

Болезнь Кикучи–Фуджимото, или некротизирующий гистиоцитарный лимфаденит, – одна из редких причин доброкачественной лимфаденопатии. Диагноз ставится на основании гистологического и иммуногистохимического анализов лимфатического узла. В статье приведены 4 клинических наблюдения пациенток с болезнью Кикучи–Фуджимото. по результатам первичного гистологического исследования биоптатов лимфатических узлов у 3 больных была заподозрена лимфома. В связи с нетипичной для гемобластоза клинической картиной были выполнены повторные биопсии и пересмотр первичного материала, после чего установлен диагноз болезни Кикучи–Фуджимото. У 3 пациенток заболевание приобрело рецидивирующий характер. За весь период наблюдения течение заболевания у всех больных было доброкачественным с удовлетворительным качеством жизни.

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