OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press56710.17650/1818-8346-2022-17-3-127-136SUPPORTIVE THERAPY ASPECTSАСПЕКТЫ ПОДДЕРЖИВАЮЩЕЙ ТЕРАПИИCardiotoxicity of anticancer drugs and radiotherapy in patients with hematologic malignancies and solid tumorsКардиотоксичность противоопухолевых препаратов и лучевой терапии у пациентов со злокачественными заболеваниями крови и сóлидными злокачественными новообразованиямиhttps://orcid.org/0000-0003-3326-4961KogoniyaL. M.КогонияЛ. М.
Russian Federation

Build. 1, 61 / 2 Shchepkina St., Moscow 129110.

129110 Москва, ул. Щепкина, 61 / 2, корп. 1.

https://orcid.org/0000-0002-9101-8606RusanovM. O.РусановМ. О.
Russian Federation

Maksim O. Rusanov.

Build. 1, 61 / 2 Shchepkina St., Moscow 129110.

Русанов Максим Олегович.

129110 Москва, ул. Щепкина, 61 / 2, корп. 1.

max-rusanov@ya.ruhttps://orcid.org/0000-0002-6672-4269ShikinaV. E.ШикинаВ. Е.
Russian Federation

Build. 1, 61 / 2 Shchepkina St., Moscow 129110.

129110 Москва, ул. Щепкина, 61 / 2, корп. 1.

M.F. Vladimirsky Moscow Regional Research Clinical InstituteМосковский областной научно-исследовательский клинический институт им. М.Ф. Владимирского200720221731271362007202220072022https://oncohematology.abvpress.ru/ongm/article/view/567

Cardioncology has emerged as a new field at the intersection of cardiology and oncology. Despite the fact that improving efficiency of antitumor treatment increased the survival of oncological hematological patients, the long-term cardiovascular consequences of this treatment have become more clinically significant.

Despite the effectiveness of modern methods of treatment, some drugs, such as Bcr-Abl kinase inhibitors, anthracyclines, HER2/Erbb2 inhibitors, vascular endothelial growth factor inhibitors, fluoropyrimidines, as well as radiation therapy can have a pronounced effect on the cardiovascular system. These toxic effects lead to cardiac arrhythmia, heart failure, vascular toxicity and even death. It is important for hematologists, oncologists and cardiologists to understand the basic diagnostic and treatment strategies that should be used in the event of toxicity of this kind. At a time when, due to the developed cardiotoxicity, antitumor therapy should be discontinued, in some cases, it is possible to consider continuing treatment with caution and careful monitoring.

Кардиоонкология возникла как новая область на стыке кардиологии и онкологии. Повышение эффективности противоопухолевого лечения увеличило выживаемость онкологических гематологических пациентов, однако долгосрочные сердечно-сосудистые последствия этого лечения стали более клинически значимыми.

Несмотря на эффективность современных методов лечения, некоторые препараты, такие как ингибиторы киназы Bcr-Abl, антрациклины, ингибиторы HER2/Erbb2, ингибиторы фактора роста эндотелия сосудов, фторпиримидины, а также лучевая терапия могут оказывать выраженное влияние на сердечно-сосудистую систему. Токсические эффекты приводят к нарушению ритма сердца, сердечной недостаточности, сосудистой токсичности и даже смерти. Для гематологов, онкологов и кардиологов важно понимать основные стратегии диагностики и лечения, которые следует использовать при возникновении подобной токсичности.

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