OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press5210.17650/1818-8346-2012-7-3-38-42BASIC RESEARCHФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ПРАКТИЧЕСКОЙ МЕДИЦИНЕ НА СОВРЕМЕННОМ ЭТАПЕThe repertoire of heavy chain immunoglobulin genes in B‑cell chronic lymphocytic leukemia in Russia and BelarusРепертуар генов тяжелой цепи иммуноглобулинов при В‑клеточном хроническом лимфолейкозе в России и БеларусиBidermanB. V.БидерманБ. В.
Russian Federation
bella_biderman@mail.ruNikitinE. A.НикитинЕ. А.
Russian Federation
SergienkoT. F.СергиенкоТ. Ф.
Russian Federation
BakunA. V.БакунА. В.
Russian Federation
TarasL. B.ТарасИ. Б.
Russian Federation
SvirnovskiyA. I.СвирновскийА. И.
Russian Federation
SudarikovA. B.СудариковА. Б.
Russian Federation
Russian Hematological Research Center, Ministry of Health of RussiaФГБУ «Гематологический научный центр» Минздрава РоссииScientific and Practical Center of Transfusiology and Medical Biotechnologies, Ministry of Health of the Republic of BelarusГУ «Республиканский научно‑практический центр трансфузиологии и медицинских биотехнологий» Министерства здравоохранения Республики Беларусь2208201273384222072014220720142012https://oncohematology.abvpress.ru/ongm/article/view/52

Mutation status of the heavy chain variable region genes has long been known as an important factor in long‑term prognosis in B‑cell chronic lymphocytic leukemia (B‑CLL). A more detailed study of the gene sequences of immunoglobulin heavy chain (IgVH) led to the discovery of stereotyped antigen receptors (SAR) — receptors that have the same set of VH‑, D‑ and JH‑genes used. Cells with SARs have been found almost in a quarter of all B‑CLL cases. This phenomenon is not observed in other lymphatic tumors. In our study, we confirmed and extended the basic observations concerning the repertoire of IgVH in B‑CLL. Differences in the B‑CLL IgVH gene repertoirs between Russia, Вelarus and other countries are also analysed and discussed.

Мутационный статус генов вариабельного региона тяжелой цепи иммуноглобулинов давно известен как важный фактор долгосрочного прогноза при В‑клеточном хроническом лимфолейкозе (В‑ХЛЛ). Более детальное изучение последовательностей генов тяжелой цепи иммуноглобулинов (IgVH) привело к открытию стереотипных антигенных рецепторов (САР) — рецепторов, у которых совпадает набор использованных VH‑, D‑ и JH‑генов. Клетки, несущие САР, обнаружены почти в четверти всех случаев В‑ХЛЛ. Данный феномен не наблюдается при других лимфатических опухолях. Подтверждены и расширены представления об основных закономерностях репертуара IgVH при В‑ХЛЛ, в частности приведены наблюдения, касающиеся САР, а также различий репертуара IgVH при В‑ХЛЛ в России и Беларуси.

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