<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">518</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2022-17-1-43-52</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>HEMATOLOGIC MALIGNANCIES: TREATMENT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЛЕЧЕНИЕ ГЕМОБЛАСТОЗОВ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Advances and perspective of the immunotherapy for relapsed/refractory multiple myeloma (interview)</article-title><trans-title-group xml:lang="ru"><trans-title>Достижения иперспективы иммунотерапии рецидивирующей/рефрактерной множественной миеломы (интервью)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Semochkin</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Семочкин</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><bold>Sergey V</bold><bold>.</bold><bold> Semochkin</bold></p><p><italic>3 2nd Botkinskiy Proezd, Moscow 125284, </italic></p><p><italic>1 Ostrovityanova St., Moscow 117997</italic></p></bio><bio xml:lang="ru"><p><bold>Сергей Вячеславович Семочкин</bold></p><p><italic>125284 Москва, 2-й Боткинский проезд, 3</italic><italic>,</italic></p><p><italic>117997 Москва, ул. Островитянова, 1 </italic></p></bio><email>semochkin_sv@rsmu.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Р.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-01-29" publication-format="electronic"><day>29</day><month>01</month><year>2022</year></pub-date><volume>17</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>43</fpage><lpage>52</lpage><history><date date-type="received" iso-8601-date="2022-01-29"><day>29</day><month>01</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-01-29"><day>29</day><month>01</month><year>2022</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/518">https://oncohematology.abvpress.ru/ongm/article/view/518</self-uri><abstract xml:lang="en"><p>.</p></abstract><trans-abstract xml:lang="ru"><p>.</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Mendeleeva L.P., Savchenko V.G., Parovichnikova L.P. et al. Analysis of transplantation activity in the Russian Federation for 2018 (report of the interregional register). Gematologiya i transfuziologiya = Russian Journal of Hematology and Transfusiology 2020;65(S1):180. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Менделеева Л.П., Савченко В.Г., Паровичникова Е.Н. и др. Анализ трансплантационной активности в РФ за 2018 г. (отчет межрегионального регистра). Гематология и трансфузиология 2020;65(S1):180.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Semochkin S. V. Treatment of doublerefractory multiple myeloma. Onkogematologiya = Oncohematology 2021;16(3): 58–73. (In Russ.). DOI: 10.17650/18188346-2021-16-3-58-73.</mixed-citation><mixed-citation xml:lang="ru">Семочкин С.В. Терапия рецидивирующей и рефрактерной множественной миеломы, отягощенной двойной рефрактерностью (обзор литературы). Онкогематология 2021;16(3):58–73. DOI: 10.17650/18188346-2021-16-3-58-73.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><mixed-citation>Kim C., Braunlin M., Mehta B., Payne R. Outcomes of triple-class (proteasome inhibitor, immunomodulator, cd38 monoclonal antibody) exposed relapsed or refractory multiple myeloma (RRMM) in United States (US) real-world practice. Blood 2021;138(Suppl 1):3042. DOI: 10.1182/blood-2021-145588.</mixed-citation></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Semochkin S.V. Biological fundamentals of application of immunomodulatory agents in treatment of multiple myeloma. Onkogematologiya = Oncohematology 2010;(1):21–31. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Семочкин С.В. Биологические основы применения иммуномодулирующих препаратов в лечении множественной миеломы. Онкогематология 2010;(1): 21–31.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><mixed-citation>Dimopoulos M., Leleu X., Palumbo A. et al. Expert panel consensus statement on the optimal use of pomalidomide in relapsed and refractory multiple myeloma. Leukemia 2014;28(8):1573–85. DOI: 10.1038/leu.2014.60.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Ludwig H., Boccadoro M., Moreau P. et al. Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network. Leukemia 2021;35(1):31–44. DOI: 10.1038/s41375-020-01016-0.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Dechow T., Aldaoud A., Behlendorf T. et al. Pomalidomide plus dexamethasone for patients with relapsed or refractory multiple myeloma: final results of the noninterventional study POSEIDON and comparison with the pivotal phase 3 clinical trials. Eur J Haematol 2022;108(2): 133–44. DOI: 10.1111/ejh.13719.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Lacy M.Q., Hayman S.R., Gertz M.A. et al. Pomalidomide (CC4047) plus lowdose dexamethasone as therapy for relapsed multiple myeloma. J Clin Oncol 2009;27(3):5008–14. DOI: 10.1200/JCO.2009.23.6802.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Lacy M.Q., Hayman S.R., Gertz M.A. et al. Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM). Leukemia 2010;24(11):1934–99. DOI: 10.1038/leu.2010.190.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Lacy M.Q., Allred J.B., Gertz M.A. et al. Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dualrefractory disease. Blood 2011;118(11):2970–5. DOI: 10.1182/blood-2011-04-348896.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Kastritis E., Roussou M., Gavriatopoulou M. et al. Impact of last lenalidomide dose, duration, and IMiD-free interval in patients with myeloma treated with pomalidomide/dexamethasone. Blood Adv 2019;3(23):4095–103. DOI: 10.1182/bloodadvances.2019000539.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Hogan K.A., Chini C.C.S., Chini E.N. The multi-faceted ecto-enzyme CD38: roles in immunomodulation, cancer, aging, and metabolic diseases. Front Immunol 2019;10:1187. DOI: 10.3389/fimmu.2019.01187.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Van de Donk N. Immunomodulatory effects of CD38-targeting antibodies. Immunol Lett 2018;199:16–22. DOI: 10.1016/j.imlet.2018.04.005.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Campbell K.S., Cohen A.D., Pazina T. Mechanisms of NK cell activation and clinical activity of the therapeutic SLAMF7 antibody, elotuzumab in multiple myeloma. Front Immunol 2018;9:2551. DOI: 10.3389/fimmu.2018.02551.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Mateos M.V., Sonneveld P., Hungria V. et al. Daratumumab, bortezomib, and dexamethasone versus bortezomib and dexamethasone in patients with previously treated multiple myeloma: threeyear follow-up of CASTOR. Clin Lymphoma Myeloma Leuk. 2020;20(8): 509–18. DOI: 10.1016/j.clml.2019.09.623.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Bahlis N.J., Dimopoulos M.A., White D.J. et al. Daratumumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: extended follow-up of POLLUX, a randomized, open-label, phase 3 study. Leukemia 2020;34(7):1875–84. DOI: 10.1038/s41375-020-0711-6.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Dimopoulos M., Quach H., Mateos M.V., et al. Carfilzomib, dexamethasone, and daratumumab versus carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (CANDOR): results from a randomised, multicentre, open-label, phase 3 study. Lancet 2020;396(10245):186–97. DOI: 10.1016/S0140-6736(20)30734-0.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Dimopoulos M.A., Terpos E., Boccadoro M. et al. Daratumumab plus pomalidomide and dexamethasone versus pomalidomide and dexamethasone alone in previously treated multiple myeloma (APOLLO): an open-label, randomised, phase 3 trial. Lancet Oncol 2021;22(6):801–12. DOI: 10.1016/S1470-2045(21)00128-5.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Moreau P., Dimopoulos M.A., Yong K. et al. Isatuximab plus carfilzomib/ dexamethasone versus carfilzomib/ dexamethasone in patients with relapsed/ refractory multiple myeloma: IKEMA Phase III study design. Future Oncol 2020;16(2):4347–58. DOI: 10.2217/fon-2019-0431.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Attal M., Richardson P.G., Rajkumar S.V. et al. Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study. Lancet 2019;394(10214):2096–107. DOI: 10.1016/S0140-6736(19)32556-5.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Dimopoulos M.A., Lonial S., White D. et al. Elotuzumab, lenalidomide, and dexamethasone in RRMM: final overall survival results from the phase 3 randomized ELOQUENT-2 study. Blood Cancer J 2020;10(9):91. DOI: 10.1038/s41408-020-00357-4.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Dimopoulos M.A., Dytfeld D., Grosicki S. et al. Elotuzumab plus pomalidomide and dexamethasone for multiple myeloma. Engl J Med 2018;379(19):1811–22. DOI: 10.1056/NEJMoa1805762.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Shah N., Chari A., Scott E. et al. B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches. Leukemia 2020;34(4):985–1005. DOI: 10.1038/s41375-020-0734-z.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Novak A.J., Darce J.R., Arendt B.K. et al. Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood 2004;103(2):689–94. DOI: 10.1182/blood-2003-06-2043.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Pont M.J., Hill T., Cole G.O. et al. Gamma-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma. Blood 2019;134(19):1585–97. DOI: 10.1182/blood.2019000050.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Jew S., Chang T., Bujarski S. et al. Normalization of serum B-cell maturation antigen levels predicts overall survival among multiple myeloma patients starting treatment. Br J Haematol 2021;192(2): 272–80. DOI: 10.1111/bjh.16752.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Lonial S., Lee H.C., Badros A. et al. Belantamab mafodotin for relapsed or refractory multiple myeloma (DREAMM-2): a two-arm, randomised, open-label, phase 2 study. Lancet Oncol 2020;21(2):207–21. DOI: 10.1016/S1470-2045(19)30788-0.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Cohen A.D., Raje N., Fowler J.A. et al. How to train your T cells: overcoming immune dysfunction in multiple myeloma. Clin Cancer Res 2020;26(7):1541–54. DOI: 10.1158/1078-0432.CCR-19-2111.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Lejeune M., Köse M.C., Duray E. et al. Bispecific, T-cell-recruiting antibodies in B-cell malignancies. Front Immunol 2020; 11:762. DOI: 10.3389/fimmu.2020.00762.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Moreau P., Usmani S.Z., Garfall A.L. et al. Updated results from MajesTEC-1: phase 1/2 study of Teclistamab, a B-cell maturation antigen x CD3 bispecific antibody, in relapsed/refractory multiple myeloma. Blood 2021;138(S1):896. DOI: 10.1182/blood-2021-147915.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Harrison S.J., Minnema M.C., Lee H.C. et al. A Phase 1 First in Human (FIH) study of AMG 701, an Anti-B-Cell Maturation Antigen (BCMA) Half-Life Extended (HLE) BiTE® (bispecific T-cell engager) molecule, in Relapsed/Refractory (RR) Multiple Myeloma (MM). Blood 2020;136(S1):28–9. DOI: 10.1182/blood-2020-134063.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Kumar S., D’Souza A., Shah N. et al. A phase 1 first-in-human study of Tnb-383B, a BCMA x CD3 bispecific T-Cell redirecting antibody, in patients with relapsed/refractory multiple myeloma. Blood 2021;138(Suppl 1):900. DOI: 10.1182/blood-2021-150757.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Pillarisetti K., Edavettal S., Mendonça M. et al. A T-cell-redirecting bispecific Gprotein-coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma. Blood 2020;135(15):1232–43. DOI: 10.1182/blood.2019003342.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Krishnan A.Y., Monique C., Minnema M.C. et al. Updated Phase 1 results from MonumenTAL-1: first-in-human study of Talquetamab, a G protein-coupled receptor family C group 5 member D x CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma. Blood 2021;138(S1):158. DOI: 10.1182/blood-2021-146868.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Cohen A.C., Harrison S.J., Krishnan A. et al. Initial clinical activity and safety of BFCR4350A, a FcRH5/CD3 T-Cellengaging bispecific antibody, in relapsed/ refractory multiple myeloma. Blood 2020;136(S1):42–3. DOI: 10.1182/blood-2020-136985.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Munshi N.C., Anderson L.D. Shah N. et al. Idecabtagene vicleucel in relapsed and refractory multiple myeloma. N Engl J Med 2021;384(8):705–16. DOI: 10.1056/NEJMoa2024850.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Martin T., Usmani S.Z., Berdeja J.G. et al. Updated results from CARTITUDE-1: PHASE 1B/2STUDY of Ciltacabtagene Autoleucel, a B-cell maturation antigendirected chimeric antigen receptor T cell therapy, in patients with relapsed/refractory multiple myeloma. Blood 2021:138(S1):549. DOI: 10.1182/blood-2021-146060.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Zhang L., Jin G., Chen Z. et al. Lenalidomide improves the antitumor activity of CAR-T cells directed toward the intracellular Wilms Tumor 1 antigen. Hematology 2021;26(1):818–26. DOI: 10.1080/16078454.2021.1981534.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Martín-Rojas R.M., Gómez-Centurión I., Bailén R. et al. Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel. Clin Case Rep 2022;10(1):e05209. DOI: 10.1002/ccr3.5209.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Möhn N., Bonda V., Grote-Levi L. et al. Neurological management and work-up of neurotoxicity associated with CAR T cell therapy. Neurol Res Pract 2022;4(1):1. DOI: 10.1186/s42466-021-00166-5.</mixed-citation></ref></ref-list></back></article>
