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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">501</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2021-16-4-23-30</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>SUPPORTIVE THERAPY ASPECTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>АСПЕКТЫ ПОДДЕРЖИВАЮЩЕЙ ТЕРАПИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Immunocorrective treatment use in the prevention of hematological and infectious complications of chemotherapy in cancer patients</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности иммунокорригирующего лечения в профилактике гематологических и инфекционных осложнений химиотерапии у онкологических больных</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9103-9688</contrib-id><name-alternatives><name xml:lang="en"><surname>Grivtsova</surname><given-names>L. Yu.</given-names></name><name xml:lang="ru"><surname>Гривцова</surname><given-names>Л. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><bold>Lyudmila Yur’evna Grivtsova</bold></p><p><italic>4 Koroleva St., Obninsk 249031, Russia</italic></p></bio><bio xml:lang="ru"><p><bold>Людмила Юрьевна Гривцова</bold></p><p><italic>Россия, 249031 Обнинск, ул. Маршала Жукова, 10</italic></p></bio><email>grivtsova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3128-8102</contrib-id><name-alternatives><name xml:lang="en"><surname>Larionova</surname><given-names>V. B.</given-names></name><name xml:lang="ru"><surname>Ларионова</surname><given-names>В. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>24 Kashirskoe Shosse, Moscow 115478, Russia</italic></p></bio><bio xml:lang="ru"><p><italic>Россия, 115478 Москва, Каширское шоссе, 24</italic></p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0023-4216</contrib-id><name-alternatives><name xml:lang="en"><surname>Falaleeva</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Фалалеева</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>4 Koroleva St., Obninsk 249031, Russia</italic></p></bio><bio xml:lang="ru"><p><italic>Россия, 249031 Обнинск, ул. Маршала Жукова, 10</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">Медицинский радиологический научный центр им. А. Ф. Цыба – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-11-11" publication-format="electronic"><day>11</day><month>11</month><year>2021</year></pub-date><volume>16</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><history><date date-type="received" iso-8601-date="2021-11-10"><day>10</day><month>11</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-11-10"><day>10</day><month>11</month><year>2021</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/501">https://oncohematology.abvpress.ru/ongm/article/view/501</self-uri><abstract xml:lang="en"><p>The article analyzes the use of immunocorrection of hematological toxicity that occurs during chemotherapy in cancer patients. Hematological toxicity, along with cardiotoxicity and hepatotoxicity often prevents the implementation of the entire planned volume of chemotherapy.</p><p>Standard therapy (colony stimulating factor use) may not be always available and there is a need to develop new and more effective strategies for supportive care. Among the various methods and approaches, the most promising may be the use of systemic immunecorrecting therapy, the possibilities of which are far from being realized in oncological practice.</p><p>The analysis of the studies summarized in this review demonstrates the effectiveness of the immunomodulator/immu‑ noadjuvant – azoximer bromide in hematological toxicity prevention in patients with various types of cancer.</p></abstract><trans-abstract xml:lang="ru"><p>В статье проанализирована возможность иммунокоррекции развития гематологической токсичности, возникающей при проведении химиотерапии у онкологических пациентов. именно гематологическая токсичность наряду с кардиотоксичностью и гепатотоксичностью часто препятствует выполнению всего запланированного объема лекарственной терапии.</p><p>Стандартная терапия поддержки (использование колониестимулирующего фактора) не всегда может быть применена, и существует необходимость разработки новых более эффективных стратегий поддерживающей терапии. среди различных методов наиболее перспективным может оказаться применение системной иммуннокорригирующей терапии, возможности которой в онкологической практике не реализованы. Анализ результатов исследований, суммированных в данном обзоре, демонстрирует эффективность российского иммуномодулятора/иммуноадъюванта азоксимера бромида в отношении предотвращения гематологической токсичности у онкологических пациентов с различными нозологическими формами рака.</p></trans-abstract><kwd-group xml:lang="en"><kwd>oncology</kwd><kwd>chemotherapy</kwd><kwd>hematological toxicity</kwd><kwd>febrile neutropenia</kwd><kwd>supportive care</kwd><kwd>immunocorrection</kwd><kwd>infectious complication</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>онкология</kwd><kwd>химиотерапия</kwd><kwd>гематологическая токсичность</kwd><kwd>фебрильная нейтропения</kwd><kwd>поддерживающая терапия</kwd><kwd>иммунокоррекция</kwd><kwd>инфекционное осложнение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Abraham J.E., Guo Q., Dorling L. et al. 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