<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">48</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2012-7-3-8-16</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="ru">Практические аспекты терапии хронического миелолейкоза в хронической фазе</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Туркина</surname><given-names>А. Г.</given-names></name><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Хельманна</surname><given-names>Р.</given-names></name><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Поспелова</surname><given-names>Т. И.</given-names></name><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name><surname>Виноградова</surname><given-names>Т. И.</given-names></name><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Ионова</surname><given-names>Т. И.</given-names></name><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff id="aff1"><institution>ФГБУ «Гематологический научный центр» Минздрава России</institution></aff><aff id="aff2"><institution>Гейдельбергский университет</institution></aff><aff id="aff3"><institution>ГБОУ ВПО «Новосибирский государственный медицинский университет» Минздрава России</institution></aff><aff id="aff4"><institution>Межнациональный центр исследования качества жизни</institution></aff><pub-date date-type="pub" iso-8601-date="2012-08-22" publication-format="electronic"><day>22</day><month>08</month><year>2012</year></pub-date><volume>7</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>8</fpage><lpage>16</lpage><history><date date-type="received" iso-8601-date="2014-07-22"><day>22</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-22"><day>22</day><month>07</month><year>2014</year></date></history><permissions><copyright-year>2012</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/48">https://oncohematology.abvpress.ru/ongm/article/view/48</self-uri><abstract xml:lang="ru"><p>.</p></abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Marin D., Bazeos A., Mahon F‑X. et al. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol 2010;28:2381−8.</mixed-citation><mixed-citation xml:lang="ru">Marin D., Bazeos A., Mahon F‑X. et al. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol 2010;28:2381−8.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Baccarani M., Cortes J., Pane F. et al. Chronic myeloid leukemia: an update of concepts and management recommendations of European Leukemia Net. J Clin Oncol 2009;27:6041−51.</mixed-citation><mixed-citation xml:lang="ru">Baccarani M., Cortes J., Pane F. et al. Chronic myeloid leukemia: an update of concepts and management recommendations of European Leukemia Net. J Clin Oncol 2009;27:6041−51.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Shah N.P., Kantarjian H.M., Kim D‑W. et al. Six‑year follow‑up of patients with imatinib-resistant or -intolerant chronicphase chronic myeloid leukemia (CML‑CP) receiving dasatinib. ASCO 2012, abstract 6506.</mixed-citation><mixed-citation xml:lang="ru">Shah N.P., Kantarjian H.M., Kim D‑W. et al. Six‑year follow‑up of patients with imatinib-resistant or -intolerant chronicphase chronic myeloid leukemia (CML‑CP) receiving dasatinib. ASCO 2012, abstract 6506.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Kantarjian H.M., Giles F.J., Bhalla K.N. et al. Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24‑month follow‑up results. Blood 2011; 117(4):1141−5.</mixed-citation><mixed-citation xml:lang="ru">Kantarjian H.M., Giles F.J., Bhalla K.N. et al. Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24‑month follow‑up results. Blood 2011; 117(4):1141−5.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Cortes J.E., Kantarjian H.M., Brummendorf T.H. et al. Safety and efficacy of bosutinib (SKI‑606) in chronic phase Philadelphia chromosome — positive chronic myeloid leukemia patients with resistance or intolerance to imatinib. Blood 2011;118(17):4567−76.</mixed-citation><mixed-citation xml:lang="ru">Cortes J.E., Kantarjian H.M., Brummendorf T.H. et al. Safety and efficacy of bosutinib (SKI‑606) in chronic phase Philadelphia chromosome — positive chronic myeloid leukemia patients with resistance or intolerance to imatinib. Blood 2011;118(17):4567−76.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Porkka K., Khoury H.J., Paquette R.L. et al. Dasatinib 100 mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukemia in chronic phase and efficacy is unaffected in patients who develop pleural effusion. Cancer 2010; 116:377−86.</mixed-citation><mixed-citation xml:lang="ru">Porkka K., Khoury H.J., Paquette R.L. et al. Dasatinib 100 mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukemia in chronic phase and efficacy is unaffected in patients who develop pleural effusion. Cancer 2010; 116:377−86.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Jabbour E., Deininger M. and Hochhaus A. Management of adverse events associated with tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia. Leukemia 2011; 25(2):201−10.</mixed-citation><mixed-citation xml:lang="ru">Jabbour E., Deininger M. and Hochhaus A. Management of adverse events associated with tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia. Leukemia 2011; 25(2):201−10.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Masiello D., Gorospe G. and Yang A.S. The occurrence and management of fluid retention associated with TKI therapy in CML, with a focus on dasatinib. J Hematol Oncol 2009;2:46.</mixed-citation><mixed-citation xml:lang="ru">Masiello D., Gorospe G. and Yang A.S. The occurrence and management of fluid retention associated with TKI therapy in CML, with a focus on dasatinib. J Hematol Oncol 2009;2:46.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Le Coutre P., Rea D., Abruzzese E. et al. Severe peripheral arterial disease during nilotinib therapy. JNCI 2011;103(17):1347−8.</mixed-citation><mixed-citation xml:lang="ru">Le Coutre P., Rea D., Abruzzese E. et al. Severe peripheral arterial disease during nilotinib therapy. JNCI 2011;103(17):1347−8.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Giles F.J., Mauro M.J., Hong F. et al. Retrospective Cohort analysis of Peripheral Arterial Occlusive Disease (PAOD) events in patients (pts) with Chronic Myeloid Leukemia in Chronic Phase (CML‑CP). Blood (ASH Annual Meeting Abstracts), Nov 2011;118:2757.</mixed-citation><mixed-citation xml:lang="ru">Giles F.J., Mauro M.J., Hong F. et al. Retrospective Cohort analysis of Peripheral Arterial Occlusive Disease (PAOD) events in patients (pts) with Chronic Myeloid Leukemia in Chronic Phase (CML‑CP). Blood (ASH Annual Meeting Abstracts), Nov 2011;118:2757.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Montani, D., Bergot E., Guenther S. et al. Pulmonary Arterial hypertension in patients treated by dasatinib. Circulation 2012;125:2128−37.</mixed-citation><mixed-citation xml:lang="ru">Montani, D., Bergot E., Guenther S. et al. Pulmonary Arterial hypertension in patients treated by dasatinib. Circulation 2012;125:2128−37.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Cortes J.E., Kim D‑W., Pinilla‑Ibarz J. et al. Initial findings from the PACE Trial: A pivotal phase 2 study of ponatinib in patients with CML and Ph+ all resistant or intolerant to dasatinib or nilotinib, or with the T315I mutation. Blood (ASH Annual Meeting Abstracts), Nov 2011;118:109.</mixed-citation><mixed-citation xml:lang="ru">Cortes J.E., Kim D‑W., Pinilla‑Ibarz J. et al. Initial findings from the PACE Trial: A pivotal phase 2 study of ponatinib in patients with CML and Ph+ all resistant or intolerant to dasatinib or nilotinib, or with the T315I mutation. Blood (ASH Annual Meeting Abstracts), Nov 2011;118:109.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Druker B.J., Guilhot F., O’Brien S.G. et al. Five‑year follow‑up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006;355:2408−17.</mixed-citation><mixed-citation xml:lang="ru">Druker B.J., Guilhot F., O’Brien S.G. et al. Five‑year follow‑up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006;355:2408−17.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Saglio G., Kim D‑W., Issaragrisil S. et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 2010;362:2251−9.</mixed-citation><mixed-citation xml:lang="ru">Saglio G., Kim D‑W., Issaragrisil S. et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 2010;362:2251−9.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. De Lavallade H., Apperley J.F., Khorashad J.S. et al. Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to‑treat analysis. J Clin Oncol 2008;26:3358−63.</mixed-citation><mixed-citation xml:lang="ru">De Lavallade H., Apperley J.F., Khorashad J.S. et al. Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to‑treat analysis. J Clin Oncol 2008;26:3358−63.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Hochhaus A., Shah N.P., Cortes J.E. et al. Dasatinib vs. imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: DASISION 3‑year follow‑up. ASCO 2012, abstract 6504.</mixed-citation><mixed-citation xml:lang="ru">Hochhaus A., Shah N.P., Cortes J.E. et al. Dasatinib vs. imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: DASISION 3‑year follow‑up. ASCO 2012, abstract 6504.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Kantarjian H.P., Hochhaus A., Saglio G. et al. Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosomepositiva, chronic myeloid leukemia: 24‑month minimum follow‑up of the phase 3 randomised ENESTnd trial. Lancet Oncol 2011;12:841−51.</mixed-citation><mixed-citation xml:lang="ru">Kantarjian H.P., Hochhaus A., Saglio G. et al. Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosomepositiva, chronic myeloid leukemia: 24‑month minimum follow‑up of the phase 3 randomised ENESTnd trial. Lancet Oncol 2011;12:841−51.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Quintás‑Cardama A. and Cortes J. Molecular biology of bcr‑abl1‑positive chronic myeloid leukemia. Blood 2009 Feb 19;113(8):1619−30.</mixed-citation><mixed-citation xml:lang="ru">Quintás‑Cardama A. and Cortes J. Molecular biology of bcr‑abl1‑positive chronic myeloid leukemia. Blood 2009 Feb 19;113(8):1619−30.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Dierov J., Sanchez P.V., Burke B.A. et al. BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold. Leukemia 2009 Feb;23(2):279−86.</mixed-citation><mixed-citation xml:lang="ru">Dierov J., Sanchez P.V., Burke B.A. et al. BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold. Leukemia 2009 Feb;23(2):279−86.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Skorski T. BCR/ABL, DNA damage and DNA repair: implications for new treatment concepts. Leuk Lymphoma 2008 Apr;49(4):610−4.</mixed-citation><mixed-citation xml:lang="ru">Skorski T. BCR/ABL, DNA damage and DNA repair: implications for new treatment concepts. Leuk Lymphoma 2008 Apr;49(4):610−4.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Neverova L., Zakharova A., Udovichenko A. et al. Additional chromosome aberrations in chronic myeloid leukemia patients undergoing tyrosine kinase inhibitors therapy. EHA 2010, poster 0822.</mixed-citation><mixed-citation xml:lang="ru">Neverova L., Zakharova A., Udovichenko A. et al. Additional chromosome aberrations in chronic myeloid leukemia patients undergoing tyrosine kinase inhibitors therapy. EHA 2010, poster 0822.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
