OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press4610.17650/1818-8346-2013-8-1-65-71NEW TRENDS IN MEDICAL SCIENCEНОВЫЕ НАПРАВЛЕНИЯ МЕДИЦИНСКОЙ НАУКИFullerene and apoptosisФуллерены и апоптозOrlovaM. A.ОрловаМ. А.
Russian Federation

Химический факультет, кафедра радиохимии

orlova.radiochem@mail.ruTrofimovaT. P.ТрофимоваТ. П.
Russian Federation

Химический факультет, кафедра радиохимии

OrlovA. P.ОрловА. П.
Russian Federation

медико-биологический факультет, кафедра медицинских нанобиотехнологий

ShatalovO. A.ШаталовО. А.
Russian Federation

фармацевтический факультет, кафедра фармакологии

NapolovYu. K.НаполовЮ. К.
Russian Federation

фармацевтический факультет, кафедра фармакологии

SvistunovA. A.СвистуновА. А.
Russian Federation

фармацевтический факультет, кафедра фармакологии

ChekhoninV. P.ЧехонинВ. П.
Russian Federation

медико-биологический факультет, кафедра медицинских нанобиотехнологий

M.V. Lomonosov Moscow State UniversityФГБОУ ВПО «Московский государственный университет им. М.В. Ломоносова»N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииI.M. Sechenov Moscow State Medical University, Ministry of Health of RussiaГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России2202201381657122072014220720142013https://oncohematology.abvpress.ru/ongm/article/view/46

Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immediately and long-term consequences of their effects in vivo which is a true obstacle on the way leading to practical medical use of them. First, this concerns their impact on the proliferation, apoptosis and necrosis regulation. Fullerene nanoparticle functionalization type, their sizes and surface nanopathology are of great importance to further promoting of either cytoprotective or cytotoxic effects. This lecture provides modern concept analysis regarding fullerenes effects on apoptosis pathway in normal and tumor cells.

Многие представители обширного семейства водорастворимых аддуктов фуллеренов и наночастиц на их основе привлек ают серьезное внимание как противовирусные агенты, противоопухолевые агенты и средства адресной доставки лекарств. Сегодня получено огромное количество таких производных фуллерена С60. Однако для внедрения фуллереновых производных в медицинскую практику необходимо понимание причин и механизмов прямых и отдаленных последствий их эффектов in vivo. В первую очередь это касается их влияния на регуляцию процессов пролиферации, апоптоза и некроза. Огромное значение имеют способ получения, функционализации и морфология фуллереновых наночастиц (их размеры, форма, рельеф поверхности, аффинность к клеточным структурам), т. е. параметры, в зависимости от которых биологические эффекты наночастиц могут меняться от цитопротекторного до цитотоксического. В данной лекции содержится анализ современных представлений о влиянии фуллеренов и их производных на сигнальные пути апоптоза нормальных и опухолевых клеток.

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