OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press44410.17650/1818-8346-2020-15-4-38-51DIAGNOSIS AND TREATMENT OF HEMOBLASTOSESДИАГНОСТИКА И ЛЕЧЕНИЕ ГЕМОБЛАСТОЗОВRHD and RHCE genes polymorphism: literature reviewПолиморфизм генов RHD и RHCE: обзор зарубежной литературы и собственных публикацийhttps://orcid.org/0000-0002-9423-2640GolovkinaL. L.ГоловкинаЛ. Л.
Russian Federation

4a Novyy Zykovskiy Proezd, Moscow 125167

Лариса Леонидовна Головкина

125167 Москва, Новый Зыковский проезд, 4а

largol@mail.ruhttps://orcid.org/0000-0002-7730-8367KalandarovR. S.КаландаровР. С.
Russian Federation

4a Novyy Zykovskiy Proezd, Moscow 125167

125167 Москва, Новый Зыковский проезд, 4а

National Medical Research Center for Hematology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России0712202015438510612202006122020https://oncohematology.abvpress.ru/ongm/article/view/444

The article provides a literature review about RHD and RHCE polymorphisms which encode different RhD and RhC antigen variants. The data about genes RHD and RHCE polymorphisms, RhD weak types, RhD partial types and RhC variants in Russians is presented for the first time. The molecular and serological characteristics of rare RhD and RhC antigens are summarized. The role of serological and molecular methods in Rhesus system antigens identifying is shown.

В статье представлен обзор литературы, посвященной полиморфизмам генов RHD и RHCE, кодирующим различные варианты антигенов RhD и RhC. Впервые приведены данные о полиморфизмах этих генов – типах слабого и парциального антигенов RhD и вариантах антигена RhC, встречающихся у россиян, в основном у пациентов с заболеванием системы крови. Суммированы молекулярно-серологические характеристики редких антигенов системы Резус. Описаны особенности методических подходов определения резус-фенотипа эритроцитов серологическими методами, направленных на избежание ошибок при интерпретации результатов исследования.

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