OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press44310.17650/1818-8346-2020-15-4-29-37DIAGNOSIS AND TREATMENT OF HEMOBLASTOSESДИАГНОСТИКА И ЛЕЧЕНИЕ ГЕМОБЛАСТОЗОВCancer-testis antigen MAGE-C1/ CT7 in multiple myeloma: literature reviewРаково-тестикулярный антиген MAGE-C1 / CT7 при множественной миеломе: обзор литературыhttps://orcid.org/0000-0001-6736-064XMakuninaE. A.МакунинаЭ. А.
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

Элеонора Анатольевна Макунина

125167 Москва, Новый Зыковский проезд, 4

Candy-BE@yandex.ruNational Medical Research Center for Hematology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России0712202015429370612202006122020https://oncohematology.abvpress.ru/ongm/article/view/443

Group of tumor-associated antigens, which is normally expressed in placental cells and testicular germ cells, is called cancer-testis antigens. To date, more than 40 gene families have been identified that encode cancer-testis antigens, and their expression has been studied in many types of malignant diseases. It is assumed that the expression of cancer-testis antigens can contribute to the development of the tumor transformation process, including hematological diseases. Of particular interest in the pathogenesis of multiple myeloma is the MAGE-C1/CT7 antigen, the expression of which is most often detected in this case. According to data published by various authors, the expression of MAGEC1 in multiple myeloma can be considered as an additional marker of a poor disease prognosis, represent the effectiveness of chemotherapy approaches, and, possibly, be an earlier predictor of relapse or progression.

Группа опухолеассоциированных антигенов, экспрессия которых в норме описана в плацентарных клетках и зародышевых клетках яичка, получила название «раково-тестикулярные антигены». В настоящее время идентифицировано более 40 семейств генов, кодирующих раково-тестикулярные антигены, и их экспрессия изучена при многих типах злокачественных заболеваний. Предполагается, что экспрессия раково-тестикулярных антигенов может способствовать развитию процесса опухолевой трансформации, в том числе и при гематологических заболеваниях. Особый интерес в патогенезе множественной миеломы представляет антиген MAGE-C1/СT7, экспрессия которого наиболее часто выявляется при данном заболевании. Согласно опубликованным данным экспрессия MAGE-C1/СT7 при множественной миеломе может выступать в качестве дополнительного маркера неблагоприятного прогноза заболевания, отражать эффективность химиотерапевтических подходов и, возможно, являться более ранним предиктором рецидива или прогрессии.

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