OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press4310.17650/1818-8346-2013-8-1-46-51HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯTrends in the treatment of cytomegalovirus infection in oncohematological patientsСовременные подходы к лечению цитомегаловирусной инфекции у онкогематологических больныхBalashovD. N.БалашовД. Н.
Russian Federation
bala8@yandex.ruDmitriy Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава России2202201381465122072014220720142013https://oncohematology.abvpress.ru/ongm/article/view/43

Cytomegalovirus (CMV)-related complications remain an extremely serious and urgent problem in immunocompromised patients. Ganciclovir (GCV) is efficient for the treatment of CMV-infection, but myelotoxicity limits the possibilities of their application. In addition, prolonged or intermittent courses of antiviral drugs predispose to the development of CMV drug-resistant strains. Valganciclovir is a safe and effective alternative to intravenous GCV. Despite the well-spread application of effective methods of early detection and pre-emptive treatment, the issue of the control of CMV-infection is not resolved. High intensive immunoablative therapy (alemtuzumab, ATG, еtс.) and hematopoietic stem cell transplantation (HSCT) from alternative donors greatly increase the risk of life-threatening visceral CMV-infections in patients. Thereby, studies of new therapeutic approaches (for example, transfusion of CMV-specific T-cells) are actually in process.

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