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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">40</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2013-8-1-17-32</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Translocation t(1;11)(p32;q23) with MLL-EPS15 fusion gene formation in acute leukemias: a review and 6 new case reports. Approaches to minimal residual disease monitoring</article-title><trans-title-group xml:lang="ru"><trans-title>Транслокация t(1;11)(p32;q23) с образованием химерного гена MLL-EPS15 при острых лейкозах: обзор литературы и описание 6 новых случаев. Подходы к мониторированию минимальной остаточной болезни</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tsaur</surname><given-names>G. A.</given-names></name><name xml:lang="ru"><surname>Цаур</surname><given-names>Г. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>tsaur@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Popov</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Попов</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Plekhanova</surname><given-names>O. M.</given-names></name><name xml:lang="ru"><surname>Плеханова</surname><given-names>О. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kustanovich</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Кустанович</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Aleynikova</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Алейникова</surname><given-names>О. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gindina</surname><given-names>T. L.</given-names></name><name xml:lang="ru"><surname>Гиндина</surname><given-names>Т. Л.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Demina</surname><given-names>A. S.</given-names></name><name xml:lang="ru"><surname>Демина</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Druy</surname><given-names>A. Ye.</given-names></name><name xml:lang="ru"><surname>Друй</surname><given-names>А. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kovalev</surname><given-names>S. Yu.</given-names></name><name xml:lang="ru"><surname>Ковалев</surname><given-names>С. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kondratchik</surname><given-names>K. L.</given-names></name><name xml:lang="ru"><surname>Кондратчик</surname><given-names>К. Л.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff7"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Misyurin</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Мисюрин</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff8"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Myakova</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Мякова</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff8"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Riger</surname><given-names>T. O.</given-names></name><name xml:lang="ru"><surname>Ригер</surname><given-names>Т. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Savelyev</surname><given-names>L. I.</given-names></name><name xml:lang="ru"><surname>Савельев</surname><given-names>Л. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sokova</surname><given-names>O. I.</given-names></name><name xml:lang="ru"><surname>Сокова</surname><given-names>О. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff9"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Streneva</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Стренева</surname><given-names>О. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Suchkova</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Сучкова</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff10"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Finashutina</surname><given-names>Yu. P.</given-names></name><name xml:lang="ru"><surname>Финашутина</surname><given-names>Ю. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff8"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fleyshman</surname><given-names>Ye. V.</given-names></name><name xml:lang="ru"><surname>Флейшман</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff9"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shorikov</surname><given-names>Ye. V.</given-names></name><name xml:lang="ru"><surname>Шориков</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yutskevich</surname><given-names>R. I.</given-names></name><name xml:lang="ru"><surname>Юцкевич</surname><given-names>Р. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Meyer</surname><given-names>C.</given-names></name><name xml:lang="ru"><surname>Meyer</surname><given-names>С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff11"/></contrib><contrib contrib-type="author"><name><surname>Marschalek</surname><given-names>R.</given-names></name><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff11"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fechina</surname><given-names>L. G.</given-names></name><name xml:lang="ru"><surname>Фечина</surname><given-names>Л. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Regional Childrenʼs Clinical Hospital №1&#13;
&#13;
Research Institute of Medical Cell Technologies</institution></aff><aff><institution xml:lang="ru">ГБУЗ CO «Областная детская клиническая больница № 1»&#13;
&#13;
ГБУЗ СО «Институт медицинских клеточных технологий»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Regional Childrenʼs Clinical Hospital №1</institution></aff><aff><institution xml:lang="ru">ГБУЗ CO «Областная детская клиническая больница № 1»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Belarusian Research Center for Pediatric Hematology, Oncology and Immunology</institution></aff><aff><institution xml:lang="ru">ГУ «Республиканский научно-практический центр детской онкологии, гематологии и иммунологии»</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Raisa Gorbacheva Memorial Institute of Children Hematology and Transplantation, St.-Petersburg I.P. Pavlov State Medical University,&#13;
Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">Институт детской гематологии и трансплантологии им. Р.М. Горбачевой ГБОУ ВПО «Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Regional Childrenʼs Clinical Hospital №1&#13;
&#13;
Research Institute of Medical Cell Technologies&#13;
&#13;
Ural State Medical Academy</institution></aff><aff><institution xml:lang="ru">ГБУЗ CO «Областная детская клиническая больница № 1»&#13;
&#13;
ГБУЗ СО «Институт медицинских клеточных технологий»&#13;
&#13;
ГБОУ ВПО «Уральская государственная медицинская академия»</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">The first President of Russia Boris Yeltsin Ural Federal University</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВПО «Уральский федеральный университет им. первого Президента России Б.Н. Ельцина»</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">Morozov Children Municipal Clinical Hospital</institution></aff><aff><institution xml:lang="ru">Морозовская детская городская клиническая больница</institution></aff></aff-alternatives><aff-alternatives id="aff8"><aff><institution xml:lang="en">Dmitriy Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии&#13;
им. Д. Рогачева» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff9"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН</institution></aff></aff-alternatives><aff-alternatives id="aff10"><aff><institution xml:lang="en">Hematology Research Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Гематологический научный центр» Минздрава России</institution></aff></aff-alternatives><aff id="aff11"><institution>Diagnostic Center of Acute Leukemia, Institute of Pharmaceutical Biology / ZAFES, Goethe-University of Frankfurt</institution></aff><pub-date date-type="pub" iso-8601-date="2013-02-22" publication-format="electronic"><day>22</day><month>02</month><year>2013</year></pub-date><volume>8</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>17</fpage><lpage>32</lpage><history><date date-type="received" iso-8601-date="2014-07-22"><day>22</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-22"><day>22</day><month>07</month><year>2014</year></date></history><permissions><copyright-year>2013</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/40">https://oncohematology.abvpress.ru/ongm/article/view/40</self-uri><abstract xml:lang="en"><p>We performed clinical and laboratory characterization of patients with rare translocation t(1;11)(p32;q23) leading to MLL-EPS15 fusion gene formation. Study cohort consisted of 33 primary acute leukemia (AL) cases including 6 newly diagnosed and 27 patients previously described in literature. Among study group patients t(1;11)(p32;q23) was found most frequently in infant AL cases (median age 8 months). In acute lymphoblastic leukemia (ALL) male/female ratio was 1:3, in acute myeloid leukemia (AML) it was 1:1. Additional cytogenetic aberrations in 38 % of patients were revealed. The most frequent breakpoint position in EPS15 gene was intron 1. Four different types of MLLEPS15 fusion gene transcripts were detected. Primers-probe-plasmid combination for MLL-EPS15 fusion gene transcript monitoring by realtime quantitative polymerase chain reaction (RQ-PCR) was developed and successfully applied. In 3 patients RQ-PCR was done on genomic DNA for absolute quantification of MLL-EPS15 fusion gene. High qualitative concordance rate (92 %) was noted between minimal residual disease data obtained in cDNA and genomic DNA for MLL-EPS15 fusion detection.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>acute leukemia</kwd><kwd>infants</kwd><kwd>MLL rearrangements</kwd><kwd>translocation t(1</kwd><kwd>11)(p32</kwd><kwd>q23)</kwd><kwd>MLL-EPS15 fusion gene</kwd><kwd>minimal residual disease</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>острый лейкоз</kwd><kwd>дети первого года жизни</kwd><kwd>перестройки гена MLL</kwd><kwd>транслокация t(1</kwd><kwd>11)(p32</kwd><kwd>q23)</kwd><kwd>химерный ген MLL-EPS15</kwd><kwd>минимальная остаточная болезнь</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Armstrong S., Look A. Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol 2005;23:6306–15.</mixed-citation><mixed-citation xml:lang="ru">Armstrong S., Look A. Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol 2005;23:6306–15.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Schoch C., Schnittger S., Klaus M. et al. AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic</mixed-citation><mixed-citation xml:lang="ru">Schoch C., Schnittger S., Klaus M. et al. AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><mixed-citation>impact in an unselected series of 1897 cytogenetically analyzed AML cases. Blood 2003;102:2395–402.</mixed-citation></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">3. Meyer С., Kowarz E., Hofmann J. et al. New insights to the MLL recombinome of acute leukemias. Leukemia 2009;23:1490–9.</mixed-citation><mixed-citation xml:lang="ru">Meyer С., Kowarz E., Hofmann J. et al. New insights to the MLL recombinome of acute leukemias. Leukemia 2009;23:1490–9.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">4. Harrison C., Cuneo A., Clark R. et al. Ten novel 11q23 chromosomal partner sites. Leukemia 1998;12:811–22.</mixed-citation><mixed-citation xml:lang="ru">Harrison C., Cuneo A., Clark R. et al. Ten novel 11q23 chromosomal partner sites. Leukemia 1998;12:811–22.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">5. Williams D., Look A., Melvin S. et al. New chromosomal translocations correlate with specific lmmunophenotypes of childhood acute lymphoblastic leukemia. Cell 1984;36:101–9.</mixed-citation><mixed-citation xml:lang="ru">Williams D., Look A., Melvin S. et al. New chromosomal translocations correlate with specific lmmunophenotypes of childhood acute lymphoblastic leukemia. Cell 1984;36:101–9.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">6. Kaneko Y., Maseki N., Takasaki N. et al. Clinical and hematologic characteristics in acute leukemia with 11q23 translocations. Blood 1986;67:484–91.</mixed-citation><mixed-citation xml:lang="ru">Kaneko Y., Maseki N., Takasaki N. et al. Clinical and hematologic characteristics in acute leukemia with 11q23 translocations. Blood 1986;67:484–91.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">7. Gregoire M., Peeters M., Bene M. et al. K lymphoblastic leukemia. Haematol Blood Transfus 1987;30:504–8.</mixed-citation><mixed-citation xml:lang="ru">Gregoire M., Peeters M., Bene M. et al. K lymphoblastic leukemia. Haematol Blood Transfus 1987;30:504–8.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">8. Selypes A., László A. A new translocation t(1;4;11) in congenital acute nonlymphocytic leukemia (acute myeloblastic leukemia). Hum Genet 1987;76:106–8.</mixed-citation><mixed-citation xml:lang="ru">Selypes A., László A. A new translocation t(1;4;11) in congenital acute nonlymphocytic leukemia (acute myeloblastic leukemia). Hum Genet 1987;76:106–8.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">9. Hagemeijer A., van Dongen J., Slater R. et al. Characterization of the blast cells in acute leukemia with translocation (4;11): report of eight additional cases and of one case with a variant translocation. Leukemia 1987;1:24–31.</mixed-citation><mixed-citation xml:lang="ru">Hagemeijer A., van Dongen J., Slater R. et al. Characterization of the blast cells in acute leukemia with translocation (4;11): report of eight additional cases and of one case with a variant translocation. Leukemia 1987;1:24–31.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">10. Raimondi S., Peiper S., Kitchingman G. et al. Childhood acute lymphoblastic leukemia with chromosomal breakpoints at 11q23. Blood 1989;73:1627–34.</mixed-citation><mixed-citation xml:lang="ru">Raimondi S., Peiper S., Kitchingman G. et al. Childhood acute lymphoblastic leukemia with chromosomal breakpoints at 11q23. Blood 1989;73:1627–34.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">11. Shippey C., Lawlor E., Secker-Walker L. Isochromosome 9q in acute lymphoblastic leukemia: a new non-random finding. Leukemia 1989;3:195–9.</mixed-citation><mixed-citation xml:lang="ru">Shippey C., Lawlor E., Secker-Walker L. Isochromosome 9q in acute lymphoblastic leukemia: a new non-random finding. Leukemia 1989;3:195–9.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">12. Abshire T., Buchanan G., Jackson J. et al. Morphologic, immunologic and cytogenetic studies in children with acute lymphoblastic leukemia at diagnosis and relapse: a Pediatric Oncology Group study. Leukemia 1992;6:357–62.</mixed-citation><mixed-citation xml:lang="ru">Abshire T., Buchanan G., Jackson J. et al. Morphologic, immunologic and cytogenetic studies in children with acute lymphoblastic leukemia at diagnosis and relapse: a Pediatric Oncology Group study. Leukemia 1992;6:357–62.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">13. Bernard O., Mauchauffe M., Mecucci C. et al. A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL. Oncogene 1994;9: 1039–45.</mixed-citation><mixed-citation xml:lang="ru">Bernard O., Mauchauffe M., Mecucci C. et al. A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL. Oncogene 1994;9: 1039–45.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">14. Felix C., Hosler M., Slater D. et al. MLL genomic breakpoint distribution within the breakpoint cluster region in de novo leukemia in children. J Pediatr Hematol Oncol 1998;20:299–308.</mixed-citation><mixed-citation xml:lang="ru">Felix C., Hosler M., Slater D. et al. MLL genomic breakpoint distribution within the breakpoint cluster region in de novo leukemia in children. J Pediatr Hematol Oncol 1998;20:299–308.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">15. Bergh von A., Emanuel B., Zelderen-Bhola van S. et al. A DNA probe combination for improved detection of MLL/11q23 breakpoints by double-color interphase-FISH in acute leukemias. Genes</mixed-citation><mixed-citation xml:lang="ru">Bergh von A., Emanuel B., Zelderen-Bhola van S. et al. A DNA probe combination for improved detection of MLL/11q23 breakpoints by double-color interphase-FISH in acute leukemias. Genes</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><mixed-citation>Chromosomes and Cancer 2000;28:14–22.</mixed-citation></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">16. Chessells J., Harrison C., Kempski H. et al. Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party.Leukemia 2002;16:776–84.</mixed-citation><mixed-citation xml:lang="ru">Chessells J., Harrison C., Kempski H. et al. Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party.Leukemia 2002;16:776–84.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">17. Park K., Lee D., Lee H. et al. Granulocytic Sarcoma in MLL-Positive Infant Acute Myelogenous Leukemia: Fluorescence in Situ Hybridization Study of Childhood Acute Myelogenous Leukemia for</mixed-citation><mixed-citation xml:lang="ru">Park K., Lee D., Lee H. et al. Granulocytic Sarcoma in MLL-Positive Infant Acute Myelogenous Leukemia: Fluorescence in Situ Hybridization Study of Childhood Acute Myelogenous Leukemia for</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><mixed-citation>Detecting MLL Rearrangement. Am J Pathol 2001;159(6):2011–6.</mixed-citation></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">18. Kim H., Cho H., Kim E. et al. A study on 289 consecutive Korean patients with acute leukaemias revealed fluorescence in situ hybridization detects the MLL translocation without cytogenetic evidence both initially and during follow-up. Br J Haematol 2002;119(4):930–9.</mixed-citation><mixed-citation xml:lang="ru">Kim H., Cho H., Kim E. et al. A study on 289 consecutive Korean patients with acute leukaemias revealed fluorescence in situ hybridization detects the MLL translocation without cytogenetic evidence both initially and during follow-up. Br J Haematol 2002;119(4):930–9.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">19. Douet-Guilbert N., Morel F., Le Bris M. et al. Rearrangement of the MLL gene in acute myeloblastic leukemia: report of two rare translocations. Cancer Genet Cytogenet2005;157:169–74.</mixed-citation><mixed-citation xml:lang="ru">Douet-Guilbert N., Morel F., Le Bris M. et al. Rearrangement of the MLL gene in acute myeloblastic leukemia: report of two rare translocations. Cancer Genet Cytogenet2005;157:169–74.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">20. Sagawa M., Shimizu T., Shimizu T. et al. Establishment of a new human acute monocytic leukemia cell line TZ-1 with t(1;11)(p32;q23) and fusion gene MLLEPS15. Leukemia 2006;20:1566–71.</mixed-citation><mixed-citation xml:lang="ru">Sagawa M., Shimizu T., Shimizu T. et al. Establishment of a new human acute monocytic leukemia cell line TZ-1 with t(1;11)(p32;q23) and fusion gene MLLEPS15. Leukemia 2006;20:1566–71.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">21. Kotecha R., Ford J., Beesley A. et al. Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins with acute</mixed-citation><mixed-citation xml:lang="ru">Kotecha R., Ford J., Beesley A. et al. Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins with acute</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><mixed-citation>lymphoblastic leukemia. Haematologica 2012;97:1447–50.</mixed-citation></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">22. Kotecha R., Murch A. Kees U., Cole C. Pre-natal, clonal origin of t(1;11)(p32;q23) acute lymphoblastic leukemia in monozygotic twins. Leuk Res 2012;36:46–50. 23. Nakamura H., Hata T., Tagawa M. et al. Chromosome 1 abnormalities at band 1p32in two atomic bomb survivors with myelodysplastic syndrome. Rinsho Ketsueki 2000;41:152–8.</mixed-citation><mixed-citation xml:lang="ru">Kotecha R., Murch A. Kees U., Cole C. Pre-natal, clonal origin of t(1;11)(p32;q23) acute lymphoblastic leukemia in monozygotic twins. Leuk Res 2012;36:46–50. 23. Nakamura H., Hata T., Tagawa M. et al. Chromosome 1 abnormalities at band 1p32in two atomic bomb survivors with myelodysplastic syndrome. Rinsho Ketsueki 2000;41:152–8.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">24. http://www.genecards.org/cgi-bin/ carddisp.pl?gene=EPS15.25. http://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085832; r=1:51819935-51985000.</mixed-citation><mixed-citation xml:lang="ru">http://www.genecards.org/cgi-bin/ carddisp.pl?gene=EPS15.25. http://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085832; r=1:51819935-51985000.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">26. Su A., Wiltshire T., Batalov S. et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci USA 2004;101:6062–7.</mixed-citation><mixed-citation xml:lang="ru">Su A., Wiltshire T., Batalov S. et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci USA 2004;101:6062–7.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">27. Salcini A., Chen H., Iannolo G. et al. Epidermal growth factor pathway substrate 15, Eps15. Int J Biochem Cell Biol 1999;31:805–9.</mixed-citation><mixed-citation xml:lang="ru">Salcini A., Chen H., Iannolo G. et al. Epidermal growth factor pathway substrate 15, Eps15. Int J Biochem Cell Biol 1999;31:805–9.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">28. Parachoniak C., Park M. Distinct recruitment of Eps15 via its coiled-coil domain is required for efficient down-regulation of the MET receptor tyrosine kinase. J Biol Chem 2009;284(13):8382–94.</mixed-citation><mixed-citation xml:lang="ru">Parachoniak C., Park M. Distinct recruitment of Eps15 via its coiled-coil domain is required for efficient down-regulation of the MET receptor tyrosine kinase. J Biol Chem 2009;284(13):8382–94.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">29. Hess J. MLL: a histone methyltransferase disrupted in leukemia. Trends in Molecular Medicine 2004;10(10):500–7.</mixed-citation><mixed-citation xml:lang="ru">Hess J. MLL: a histone methyltransferase disrupted in leukemia. Trends in Molecular Medicine 2004;10(10):500–7.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">30. Slany R. The molecular biology of mixed lineage leukemia. Haematol 2009;94:984–93.</mixed-citation><mixed-citation xml:lang="ru">Slany R. The molecular biology of mixed lineage leukemia. Haematol 2009;94:984–93.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">31. Armstrong S., Staunton J., Silverman L. et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2002;30:41–7.</mixed-citation><mixed-citation xml:lang="ru">Armstrong S., Staunton J., Silverman L. et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2002;30:41–7.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">32. Ferrando A., Armstrong S., Neuberg D. et al. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregu lation. Blood 2003;102:262–8.</mixed-citation><mixed-citation xml:lang="ru">Ferrando A., Armstrong S., Neuberg D. et al. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregu lation. Blood 2003;102:262–8.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">33. Yeoh E., Ross M., Shurtleff S. et al. Classification, subtype discovery, and prediction of out-come in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002;1:133–43.</mixed-citation><mixed-citation xml:lang="ru">Yeoh E., Ross M., Shurtleff S. et al. Classification, subtype discovery, and prediction of out-come in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002;1:133–43.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">34. Ayton P., Cleary M. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes and Development 2003;17:2298–307.</mixed-citation><mixed-citation xml:lang="ru">Ayton P., Cleary M. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes and Development 2003;17:2298–307.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">35. Trentin L., Giordan M., Dingermann Th. et al. Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients. Euro J Haematol 2009;83:406–19.</mixed-citation><mixed-citation xml:lang="ru">Trentin L., Giordan M., Dingermann Th. et al. Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients. Euro J Haematol 2009;83:406–19.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">36. Pallisgaard N., Hokland P., Riishoj D. et al. Multiplex reverse transcriptionpolymerase chain reaction for simultaneous screening of 29 translocations and chromosomal aberrations in acute leukemia. Blood 1998;92:574–88.</mixed-citation><mixed-citation xml:lang="ru">Pallisgaard N., Hokland P., Riishoj D. et al. Multiplex reverse transcriptionpolymerase chain reaction for simultaneous screening of 29 translocations and chromosomal aberrations in acute leukemia. Blood 1998;92:574–88.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">37. Dongen van J., Macintyre E., Gabert J. et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Leukemia 1999;13:1901–18.</mixed-citation><mixed-citation xml:lang="ru">Dongen van J., Macintyre E., Gabert J. et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Leukemia 1999;13:1901–18.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">38. Fechina L., Shorikov E., Tsaur G. et al. Contribution of all-trans retinoic acid to improved early relapse-free outcome in infant acute lymphoblastic leukemia comparing to the chemotherapy alone.</mixed-citation><mixed-citation xml:lang="ru">Fechina L., Shorikov E., Tsaur G. et al. Contribution of all-trans retinoic acid to improved early relapse-free outcome in infant acute lymphoblastic leukemia comparing to the chemotherapy alone.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><mixed-citation>Blood 2007;110(11):832А; abstr. 2828.</mixed-citation></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">39. ISCN 1995: An International System for Human Cytogenetic Nomenclature (1995). Ed. Mitelman F. Basel: S. Karger, 1995.</mixed-citation><mixed-citation xml:lang="ru">ISCN 1995: An International System for Human Cytogenetic Nomenclature (1995). Ed. Mitelman F. Basel: S. Karger, 1995.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">40. ISCN 2005: An International System For Human Cytogenetic Nomenclature (2005). Eds.: Shaffer L., Tommerup N. Basel: S. Karger, 2005.</mixed-citation><mixed-citation xml:lang="ru">ISCN 2005: An International System For Human Cytogenetic Nomenclature (2005). Eds.: Shaffer L., Tommerup N. Basel: S. Karger, 2005.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">41. ISCN 2009: An International System For Human Cytogenetic Nomenclature (2009). Eds.: Schaffer L., Slovak M., Campbell L. Basel: S. Karger, 2009.</mixed-citation><mixed-citation xml:lang="ru">ISCN 2009: An International System For Human Cytogenetic Nomenclature (2009). Eds.: Schaffer L., Slovak M., Campbell L. Basel: S. Karger, 2009.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">42. Coenen E., Raimondi S., Harbott J. et al. Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL -rearranged AML patients: results of an international study. Blood 2011;117:7102–11.</mixed-citation><mixed-citation xml:lang="ru">Coenen E., Raimondi S., Harbott J. et al. Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL -rearranged AML patients: results of an international study. Blood 2011;117:7102–11.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">43. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Eds.: Swerdlow S., Campo E., Harris N. et al. Lyon, France: IARC, 2008.</mixed-citation><mixed-citation xml:lang="ru">WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Eds.: Swerdlow S., Campo E., Harris N. et al. Lyon, France: IARC, 2008.</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">44. Betts D., Ammann R., Hirt A. et al. The prognostic significance of cytogenetic aberrations in childhood acute myeloid leukaemia. A study of the Swiss Paediatric Oncology Group (SPOG). Eur J Haematol 2007;78(6):468–76.</mixed-citation><mixed-citation xml:lang="ru">Betts D., Ammann R., Hirt A. et al. The prognostic significance of cytogenetic aberrations in childhood acute myeloid leukaemia. A study of the Swiss Paediatric Oncology Group (SPOG). Eur J Haematol 2007;78(6):468–76.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">45. Meyer C., Schneider B., Reichel M. et al. Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci USA2005;102(2):449–54.</mixed-citation><mixed-citation xml:lang="ru">Meyer C., Schneider B., Reichel M. et al. Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci USA2005;102(2):449–54.</mixed-citation></citation-alternatives></ref><ref id="B49"><label>49.</label><citation-alternatives><mixed-citation xml:lang="en">46. Цаур Г.А., Наседкина Т.В., Попов А.М. и др. Время достижения молекулярной ремиссии как фактор прогноза у детей первого года жизни острым лимфобластным лейкозом. Онкогематол 2010;2:46–54.</mixed-citation><mixed-citation xml:lang="ru">Цаур Г.А., Наседкина Т.В., Попов А.М. и др. Время достижения молекулярной ремиссии как фактор прогноза у детей первого года жизни острым лимфобластным лейкозом. Онкогематол 2010;2:46–54.</mixed-citation></citation-alternatives></ref><ref id="B50"><label>50.</label><citation-alternatives><mixed-citation xml:lang="en">47. Цаур Г.А., Друй А.Е., Попов А.М. и др. Возможность использования микроструйных биочипов для оценки качества и количества РНК у пациентов с онкологическими и онкогематологическими заболеваниями. Вестн Урал мед акад науки 2011;4:107–11.</mixed-citation><mixed-citation xml:lang="ru">Цаур Г.А., Друй А.Е., Попов А.М. и др. Возможность использования микроструйных биочипов для оценки качества и количества РНК у пациентов с онкологическими и онкогематологическими заболеваниями. Вестн Урал мед акад науки 2011;4:107–11.</mixed-citation></citation-alternatives></ref><ref id="B51"><label>51.</label><citation-alternatives><mixed-citation xml:lang="en">48. Gabert J., Beillard E., Velden van der V. et al. Standardization and quality control studies of ‘real-time’ quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia – a Europe Against Cancer Program. Leukemia 2003;17:2318–57.</mixed-citation><mixed-citation xml:lang="ru">Gabert J., Beillard E., Velden van der V. et al. Standardization and quality control studies of ‘real-time’ quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia – a Europe Against Cancer Program. Leukemia 2003;17:2318–57.</mixed-citation></citation-alternatives></ref><ref id="B52"><label>52.</label><citation-alternatives><mixed-citation xml:lang="en">49. Beillard E., Pallisgaard N., Velden van der V. et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using ‘real-time’ quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) – a Europe Against Cancer Program. Leukemia</mixed-citation><mixed-citation xml:lang="ru">Beillard E., Pallisgaard N., Velden van der V. et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using ‘real-time’ quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) – a Europe Against Cancer Program. Leukemia</mixed-citation></citation-alternatives></ref><ref id="B53"><label>53.</label><citation-alternatives><mixed-citation xml:lang="en">2003;17:2474–86.</mixed-citation><mixed-citation xml:lang="ru">;17:2474–86.</mixed-citation></citation-alternatives></ref><ref id="B54"><label>54.</label><citation-alternatives><mixed-citation xml:lang="en">50. Burmeister T., Marschalek R., Schneider B. et al. Monitoring minimal residual disease by quantification of genomic chromosomal breakpoint sequences in acute leukemias with MLL aberrations. Leukemia 2006;20:451–7.</mixed-citation><mixed-citation xml:lang="ru">Burmeister T., Marschalek R., Schneider B. et al. Monitoring minimal residual disease by quantification of genomic chromosomal breakpoint sequences in acute leukemias with MLL aberrations. Leukemia 2006;20:451–7.</mixed-citation></citation-alternatives></ref><ref id="B55"><label>55.</label><citation-alternatives><mixed-citation xml:lang="en">51. Velden van der V., Cazzaniga G., Schrauder A. et al. Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.</mixed-citation><mixed-citation xml:lang="ru">Velden van der V., Cazzaniga G., Schrauder A. et al. Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.</mixed-citation></citation-alternatives></ref><ref id="B56"><label>56.</label><mixed-citation>Leukemia 2007;21:604–11.</mixed-citation></ref><ref id="B57"><label>57.</label><citation-alternatives><mixed-citation xml:lang="en">52. Kaplan E., Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457–81.</mixed-citation><mixed-citation xml:lang="ru">Kaplan E., Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457–81.</mixed-citation></citation-alternatives></ref><ref id="B58"><label>58.</label><citation-alternatives><mixed-citation xml:lang="en">53. Nilson I., Loechner K., Siegler G. et al. Exon/intron structure of ALL1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukemias. Br J Haematol 1996;94(4):966–72.</mixed-citation><mixed-citation xml:lang="ru">Nilson I., Loechner K., Siegler G. et al. Exon/intron structure of ALL1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukemias. Br J Haematol 1996;94(4):966–72.</mixed-citation></citation-alternatives></ref><ref id="B59"><label>59.</label><citation-alternatives><mixed-citation xml:lang="en">54. Mitelman database of chromosome aberrations and gene fusions in cancer (2012). Mitelman F., Johansson B. Mertens F. (eds.). http://cgap.nci.nih.gov/ Chromosomes/Mitelman.</mixed-citation><mixed-citation xml:lang="ru">Mitelman database of chromosome aberrations and gene fusions in cancer (2012). Mitelman F., Johansson B. Mertens F. (eds.). http://cgap.nci.nih.gov/ Chromosomes/Mitelman.</mixed-citation></citation-alternatives></ref><ref id="B60"><label>60.</label><citation-alternatives><mixed-citation xml:lang="en">55. Huret J.-L. t(1;11)(p32;q23). Atlas Genet Cytogenet Oncol Haematol (September 2010). http://</mixed-citation><mixed-citation xml:lang="ru">Huret J.-L. t(1;11)(p32;q23). Atlas Genet Cytogenet Oncol Haematol (September 2010). http://</mixed-citation></citation-alternatives></ref><ref id="B61"><label>61.</label><mixed-citation>AtlasGeneticsOncology.org/Anomalies/t0111p32q23ID1046.html.</mixed-citation></ref><ref id="B62"><label>62.</label><citation-alternatives><mixed-citation xml:lang="en">56. Chowdhury T., Brady H. Insights from clinical studies into the role of the MLL gene in infant and childhood leukemia. Blood Cells Mol Dis 2008;40:192–9.</mixed-citation><mixed-citation xml:lang="ru">Chowdhury T., Brady H. Insights from clinical studies into the role of the MLL gene in infant and childhood leukemia. Blood Cells Mol Dis 2008;40:192–9.</mixed-citation></citation-alternatives></ref><ref id="B63"><label>63.</label><citation-alternatives><mixed-citation xml:lang="en">57. Forestier E., Schmiegelow K. The incidence peaks of the childhood acute leukemias reflect specific cytogenetic aberrations. J Pediatr Hematol Oncol 2006;28:486–95.</mixed-citation><mixed-citation xml:lang="ru">Forestier E., Schmiegelow K. The incidence peaks of the childhood acute leukemias reflect specific cytogenetic aberrations. J Pediatr Hematol Oncol 2006;28:486–95.</mixed-citation></citation-alternatives></ref><ref id="B64"><label>64.</label><citation-alternatives><mixed-citation xml:lang="en">58. Zweidler-McKay P., Hilden J. The ABCs of Infant Leukemia. Curr Probl Pediatr Adolesc Health Care 2008;38(3):78–94.</mixed-citation><mixed-citation xml:lang="ru">Zweidler-McKay P., Hilden J. The ABCs of Infant Leukemia. Curr Probl Pediatr Adolesc Health Care 2008;38(3):78–94.</mixed-citation></citation-alternatives></ref><ref id="B65"><label>65.</label><citation-alternatives><mixed-citation xml:lang="en">59. Цаур Г.А., Флейшман Е.В., Гиндина Т.Л. и др. Характеристика перестроек 11q23/MLL при остром миелоидном лейкозе у детей первого года жизни. Клин онкогематол 2012;5(4):365–71.</mixed-citation><mixed-citation xml:lang="ru">Цаур Г.А., Флейшман Е.В., Гиндина Т.Л. и др. Характеристика перестроек 11q23/MLL при остром миелоидном лейкозе у детей первого года жизни. Клин онкогематол 2012;5(4):365–71.</mixed-citation></citation-alternatives></ref><ref id="B66"><label>66.</label><citation-alternatives><mixed-citation xml:lang="en">60. Цаур Г.А., Попов А.М., Алейникова О.В. и др. Характеристика перестроек 11q23 (MLL) у детей первого года жизни с острым лимфобластнымлейкозом. Онкогематол 2011;3:57–64.</mixed-citation><mixed-citation xml:lang="ru">Цаур Г.А., Попов А.М., Алейникова О.В. и др. Характеристика перестроек 11q23 (MLL) у детей первого года жизни с острым лимфобластнымлейкозом. Онкогематол 2011;3:57–64.</mixed-citation></citation-alternatives></ref><ref id="B67"><label>67.</label><citation-alternatives><mixed-citation xml:lang="en">61. Meyer C., Schneider B., Jakob S. et al. The MLL recombinome of acute leukemias. Leukemia 2006;20:777–84.</mixed-citation><mixed-citation xml:lang="ru">Meyer C., Schneider B., Jakob S. et al. The MLL recombinome of acute leukemias. Leukemia 2006;20:777–84.</mixed-citation></citation-alternatives></ref><ref id="B68"><label>68.</label><citation-alternatives><mixed-citation xml:lang="en">62. Цаур Г.А., Попов А.М., Наседкина Т.В. и др. Прогностическое значение минимальной остаточной болезни, определенной путем выявления химерных транскриптов у детей первого года жизни,</mixed-citation><mixed-citation xml:lang="ru">Цаур Г.А., Попов А.М., Наседкина Т.В. и др. Прогностическое значение минимальной остаточной болезни, определенной путем выявления химерных транскриптов у детей первого года жизни,</mixed-citation></citation-alternatives></ref><ref id="B69"><label>69.</label><mixed-citation>больных острым лимфобластным лейкозом, получающих терапию по протоколу MLL-BABY. Гематол и трансфузиол 2012;57(4):12–22.</mixed-citation></ref><ref id="B70"><label>70.</label><citation-alternatives><mixed-citation xml:lang="en">63. Jansen M., Corral L., Velden van der V. et al. Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement. Leukemia 2007;21:633–41.</mixed-citation><mixed-citation xml:lang="ru">Jansen M., Corral L., Velden van der V. et al. Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement. Leukemia 2007;21:633–41.</mixed-citation></citation-alternatives></ref><ref id="B71"><label>71.</label><citation-alternatives><mixed-citation xml:lang="en">64. Peham M., Panzer S., Fasching K. et al. Low frequency of clonotypic Ig and T-cell receptor gene rearrangements in t(4;11) infant acute lymphoblastic leukaemia and its implication for the detection of minimal residual disease. Br J Haematol 2002;117:315–21.</mixed-citation><mixed-citation xml:lang="ru">Peham M., Panzer S., Fasching K. et al. Low frequency of clonotypic Ig and T-cell receptor gene rearrangements in t(4;11) infant acute lymphoblastic leukaemia and its implication for the detection of minimal residual disease. Br J Haematol 2002;117:315–21.</mixed-citation></citation-alternatives></ref><ref id="B72"><label>72.</label><citation-alternatives><mixed-citation xml:lang="en">65. De Zen L., Bicciato S., te Kronnie G., Basso G. Computational analysis of flowcytometry antigen expression profiles in childhood acute lymphoblastic leukemia: an MLL/AF4 identification. Leukemia</mixed-citation><mixed-citation xml:lang="ru">De Zen L., Bicciato S., te Kronnie G., Basso G. Computational analysis of flowcytometry antigen expression profiles in childhood acute lymphoblastic leukemia: an MLL/AF4 identification. Leukemia</mixed-citation></citation-alternatives></ref><ref id="B73"><label>73.</label><citation-alternatives><mixed-citation xml:lang="en">2003;17:1557–65.</mixed-citation><mixed-citation xml:lang="ru">;17:1557–65.</mixed-citation></citation-alternatives></ref><ref id="B74"><label>74.</label><citation-alternatives><mixed-citation xml:lang="en">66. Schwartz S., Rieder H., Schlaeger B. et al. Expression of the human homologue of rat NG2 in adult acute lymphoblastic leukemia: close association with MLL rearrangement and a CD10(-)/CD24(-)/CD65s(+)/CD15(+) B-cell phenotype. Leukemia 2003;17:1589–95.</mixed-citation><mixed-citation xml:lang="ru">Schwartz S., Rieder H., Schlaeger B. et al. Expression of the human homologue of rat NG2 in adult acute lymphoblastic leukemia: close association with MLL rearrangement and a CD10(-)/CD24(-)/CD65s(+)/CD15(+) B-cell phenotype. Leukemia 2003;17:1589–95.</mixed-citation></citation-alternatives></ref><ref id="B75"><label>75.</label><citation-alternatives><mixed-citation xml:lang="en">67. Attarbaschi A., Mann G., König M. et al. Mixed lineage leukemia-rearranged childhood pro-B and CD10-negative pre-B acute lymphoblastic leukemia constitute a distinct clinical entity. Clin Cancer Res 2006;12:2988–94.</mixed-citation><mixed-citation xml:lang="ru">Attarbaschi A., Mann G., König M. et al. Mixed lineage leukemia-rearranged childhood pro-B and CD10-negative pre-B acute lymphoblastic leukemia constitute a distinct clinical entity. Clin Cancer Res 2006;12:2988–94.</mixed-citation></citation-alternatives></ref><ref id="B76"><label>76.</label><citation-alternatives><mixed-citation xml:lang="en">68. Попов А.М., Вержбицкая Т.Ю., Цаур Г.А. и др. Особенности мониторинга минимальной остаточной болезни при B-линейных острых лимфобластных лейкозах методом проточной цитометрии у детей первого года жизни. Дет онкол 2008;2:32–5.</mixed-citation><mixed-citation xml:lang="ru">Попов А.М., Вержбицкая Т.Ю., Цаур Г.А. и др. Особенности мониторинга минимальной остаточной болезни при B-линейных острых лимфобластных лейкозах методом проточной цитометрии у детей первого года жизни. Дет онкол 2008;2:32–5.</mixed-citation></citation-alternatives></ref><ref id="B77"><label>77.</label><citation-alternatives><mixed-citation xml:lang="en">69. Попов А.М., Вержбицкая Т.Ю., Цаур Г.А. и др. Возможности применения NG2 для мониторинга минимальной остаточной болезни методом проточной цитометрии у детей первого года жизни</mixed-citation><mixed-citation xml:lang="ru">Попов А.М., Вержбицкая Т.Ю., Цаур Г.А. и др. Возможности применения NG2 для мониторинга минимальной остаточной болезни методом проточной цитометрии у детей первого года жизни</mixed-citation></citation-alternatives></ref><ref id="B78"><label>78.</label><mixed-citation>с острым лимфобластным лейкозом, ассоциированным с реарранжировками гена MLL. Гематол и трансфузиол 2009;6:19–22.</mixed-citation></ref><ref id="B79"><label>79.</label><citation-alternatives><mixed-citation xml:lang="en">70. Velden van der V., Сorral L. Valsecchi M. et al. Prognostic significance of minimal residual disease in infants with acute lymphoblastic leukemia treated within the Interfant- 99 protocol. Leukemia 2009;23:1073–9.</mixed-citation><mixed-citation xml:lang="ru">Velden van der V., Сorral L. Valsecchi M. et al. Prognostic significance of minimal residual disease in infants with acute lymphoblastic leukemia treated within the Interfant- 99 protocol. Leukemia 2009;23:1073–9.</mixed-citation></citation-alternatives></ref><ref id="B80"><label>80.</label><citation-alternatives><mixed-citation xml:lang="en">71. Jansen M., Velden van der V., Dongen van J. Efficient and easy detection of MLL-AF4, MLL-AF9 and MLL-ENL fusion gene transcripts by multiplex real-time quantitative RT-PCR in TaqMan and</mixed-citation><mixed-citation xml:lang="ru">Jansen M., Velden van der V., Dongen van J. Efficient and easy detection of MLL-AF4, MLL-AF9 and MLL-ENL fusion gene transcripts by multiplex real-time quantitative RT-PCR in TaqMan and</mixed-citation></citation-alternatives></ref><ref id="B81"><label>81.</label><mixed-citation>LightCycler. Leukemia 2005;19(11):2016–18.</mixed-citation></ref><ref id="B82"><label>82.</label><citation-alternatives><mixed-citation xml:lang="en">72. Szczepanski T. Why and how to quantify minimal residual disease in acute lymphoblastic leukaemia. Leukemia 2007;21:622–6</mixed-citation><mixed-citation xml:lang="ru">Szczepanski T. Why and how to quantify minimal residual disease in acute lymphoblastic leukaemia. Leukemia 2007;21:622–6</mixed-citation></citation-alternatives></ref></ref-list></back></article>
