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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">38</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2013-8-2-83-92</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>NEW TRENDS IN MEDICAL SCIENCE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>НОВЫЕ НАПРАВЛЕНИЯ МЕДИЦИНСКОЙ НАУКИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Antitumor activity of fullerene derivatives and their possible use for target drug delivery</article-title><trans-title-group xml:lang="ru"><trans-title>Противоопухолевая активность производных фуллерена и возможности их использования для адресной доставки лекарств</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Orlova</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Орлова</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Химический факультет, кафедра радиохимии</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Trofimova</surname><given-names>T. P.</given-names></name><name xml:lang="ru"><surname>Трофимова</surname><given-names>Т. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Химический факультет, кафедра радиохимии</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Orlov</surname><given-names>A. P.</given-names></name><name xml:lang="ru"><surname>Орлов</surname><given-names>А. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>медико-биологический факультет, кафедра медицинских нанобиотехнологий</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shatalov</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Шаталов</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>фармацевтический факультет, кафедра фармакологии</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Napolov</surname><given-names>Yu. K.</given-names></name><name xml:lang="ru"><surname>Наполов</surname><given-names>Ю. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>фармацевтический факультет, кафедра фармакологии</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Svistunov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Свистунов</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>фармацевтический факультет, кафедра фармакологии</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chekhonin</surname><given-names>V. P.</given-names></name><name xml:lang="ru"><surname>Чехонин</surname><given-names>В. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>медико-биологический факультет, кафедра медицинских нанобиотехнологий</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">M.V. Lomonosov Moscow State University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВПО «Московский государственный университет им. М.В. Ломоносова»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">I.M. Sechenov Moscow State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-05-22" publication-format="electronic"><day>22</day><month>05</month><year>2013</year></pub-date><volume>8</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>83</fpage><lpage>92</lpage><history><date date-type="received" iso-8601-date="2014-07-22"><day>22</day><month>07</month><year>2014</year></date></history><permissions><copyright-year>2013</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/38">https://oncohematology.abvpress.ru/ongm/article/view/38</self-uri><abstract xml:lang="en"><p>.</p></abstract><trans-abstract xml:lang="ru"><p>,</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Jalbout A.F., Hameed A.J., Trzaskowski B. Study of the structural and electronic properties of 1-(4, 5 and 6-selenenyl derivatives-3-formyl-phenyl) pyrrolidinofullerenes. J Organometal Chem 2007;692:1039–47.</mixed-citation><mixed-citation xml:lang="ru">Jalbout A.F., Hameed A.J., Trzaskowski B. Study of the structural and electronic properties of 1-(4, 5 and 6-selenenyl derivatives-3-formyl-phenyl) pyrrolidinofullerenes. J Organometal Chem 2007;692:1039–47.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Jiao F., Liu Y., Qu Y. et al. Studies on antitumor and antimetastatic activities of fullerenol in a mouse breast cancer model. Carbon 2010;48:2231–43.</mixed-citation><mixed-citation xml:lang="ru">Jiao F., Liu Y., Qu Y. et al. Studies on antitumor and antimetastatic activities of fullerenol in a mouse breast cancer model. Carbon 2010;48:2231–43.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Nishizawa C., Hashimoto N., Yokoo S. et al. Pyrrolidinium-type fullerene derivativeinduced apoptosis by the generation of reactive oxygen species in HL-60 cells. Free Radic Res 2009;43:1240–7.</mixed-citation><mixed-citation xml:lang="ru">Nishizawa C., Hashimoto N., Yokoo S. et al. Pyrrolidinium-type fullerene derivativeinduced apoptosis by the generation of reactive oxygen species in HL-60 cells. Free Radic Res 2009;43:1240–7.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Wang J., Chen C., Li B. et al. Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumorbearing mice. Biochem Pharmacol 2006;71:872–81.</mixed-citation><mixed-citation xml:lang="ru">Wang J., Chen C., Li B. et al. Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumorbearing mice. Biochem Pharmacol 2006;71:872–81.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Liu Y., Jiao F., Qiu Y. et al. Immunostimulatory properties and enhanced TNF-a mediated cellular</mixed-citation><mixed-citation xml:lang="ru">Liu Y., Jiao F., Qiu Y. et al. Immunostimulatory properties and enhanced TNF-a mediated cellular</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><mixed-citation>immunity for tumor therapy by C60(OH)20 nanoparticles. Nanotechnology 2009;20:415102–11.</mixed-citation></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">6. Liu Y., Jiao F., Qiu Y. et al. The effect of Gd@C82(OH)22 nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-α mediated cellular immunity. Biomaterials 2009;30:3934–45.</mixed-citation><mixed-citation xml:lang="ru">Liu Y., Jiao F., Qiu Y. et al. The effect of Gd@C82(OH)22 nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-α mediated cellular immunity. Biomaterials 2009;30:3934–45.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">7. Meng H., Xing G., Sun B. et al. Potent angiogenesis inhibition by the particulate form of fullerene derivatives. Acs Nano 2010;4:2773–83.</mixed-citation><mixed-citation xml:lang="ru">Meng H., Xing G., Sun B. et al. Potent angiogenesis inhibition by the particulate form of fullerene derivatives. Acs Nano 2010;4:2773–83.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">8. Prylutska S., Burlaka A.P., Klymenko P.P. et al. Using water-soluble C60 fullerenes in anticancer therapy. Cancer Nanotechnol 2011;2:105–10.</mixed-citation><mixed-citation xml:lang="ru">Prylutska S., Burlaka A.P., Klymenko P.P. et al. Using water-soluble C60 fullerenes in anticancer therapy. Cancer Nanotechnol 2011;2:105–10.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">9. Kharisov B.I., Kharissova O.V., Gomez M.J., Mendez U.O. Recent advances in the synthesis, characterization, and applications of fulleropyrrolidines. Ind Eng Chem Res 2009;48:545–71.</mixed-citation><mixed-citation xml:lang="ru">Kharisov B.I., Kharissova O.V., Gomez M.J., Mendez U.O. Recent advances in the synthesis, characterization, and applications of fulleropyrrolidines. Ind Eng Chem Res 2009;48:545–71.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">10. Mikawa M., Kato H., Okumura M. et al. Paramagnetic water-soluble metallofullerenes having the highest relaxivity for MRI contrast agents. Bioconjug Chem 2001;12:510–4.</mixed-citation><mixed-citation xml:lang="ru">Mikawa M., Kato H., Okumura M. et al. Paramagnetic water-soluble metallofullerenes having the highest relaxivity for MRI contrast agents. Bioconjug Chem 2001;12:510–4.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">11. Liu J.H., Cao L., Luo P.G. et al. Fullerene-conjugated doxorubicin in cells. Acs Appl Mater Interf 2010;2:1384–9.</mixed-citation><mixed-citation xml:lang="ru">Liu J.H., Cao L., Luo P.G. et al. Fullerene-conjugated doxorubicin in cells. Acs Appl Mater Interf 2010;2:1384–9.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">12. Montellano A., Da Ros T., Bianco A., Prato M. Fullerene C60 as a multifunctional system for drug and gene delivery. Nanoscale 2011;3:4035–44.</mixed-citation><mixed-citation xml:lang="ru">Montellano A., Da Ros T., Bianco A., Prato M. Fullerene C60 as a multifunctional system for drug and gene delivery. Nanoscale 2011;3:4035–44.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">13. Rancan F., Helmreich M., Molich A. et al. Fullerene-pyropheophorbide a complexes as sensitizer for photodynamic therapy: uptake and photo-induced cytotoxicity on Jurkat cells. J Photochem Photobiol B 2005;80:1–7.</mixed-citation><mixed-citation xml:lang="ru">Rancan F., Helmreich M., Molich A. et al. Fullerene-pyropheophorbide a complexes as sensitizer for photodynamic therapy: uptake and photo-induced cytotoxicity on Jurkat cells. J Photochem Photobiol B 2005;80:1–7.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">14. Boyd P.D., Hodgson M.C., Rickard C.E.F. et al. Selective supramolecular porphyrin/fullerene interactions. J Am Chem Soc 1999;121:10487–95.</mixed-citation><mixed-citation xml:lang="ru">Boyd P.D., Hodgson M.C., Rickard C.E.F. et al. Selective supramolecular porphyrin/fullerene interactions. J Am Chem Soc 1999;121:10487–95.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">15. Nishiyama N., Stapert H.R., Zhang G.D. et al. Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy. Bioconjugate Chem 2003;14:58–66.</mixed-citation><mixed-citation xml:lang="ru">Nishiyama N., Stapert H.R., Zhang G.D. et al. Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy. Bioconjugate Chem 2003;14:58–66.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">16. Rezayat S.M., Boushehri S.V.S., Salmanian B. et al. The porphyrin-fullerene nanoparticles to promote the ATP overproduction in myocardium: 25Mg2+-magnetic isotope effect. Eur J Med</mixed-citation><mixed-citation xml:lang="ru">Rezayat S.M., Boushehri S.V.S., Salmanian B. et al. The porphyrin-fullerene nanoparticles to promote the ATP overproduction in myocardium: 25Mg2+-magnetic isotope effect. Eur J Med</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><mixed-citation>Chem 2009;44:1554–69.</mixed-citation></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">17. Buchachenko A.L., Kuznetsov D.A., Breslavskaya N.N., Orlova M.A. Magnesium isotope effect in enzymatic phosphorylation. J Phys Chem B 2008;112:2548–56.</mixed-citation><mixed-citation xml:lang="ru">Buchachenko A.L., Kuznetsov D.A., Breslavskaya N.N., Orlova M.A. Magnesium isotope effect in enzymatic phosphorylation. J Phys Chem B 2008;112:2548–56.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">18. Nikolić N., Vranjes-Ethurić S., Janković D. et al. Preparation and biodistribution of radiolabeled fullerene C60 nanocrystals. Nanotechnol 2009;20:385102.</mixed-citation><mixed-citation xml:lang="ru">Nikolić N., Vranjes-Ethurić S., Janković D. et al. Preparation and biodistribution of radiolabeled fullerene C60 nanocrystals. Nanotechnol 2009;20:385102.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">19. Zhou Z., Lenk R.P., Dellinger A. et al. Liposomal formulation of amphiphilic fullerene antioxidants. Bioconj Chem 2010;21:1656–61.</mixed-citation><mixed-citation xml:lang="ru">Zhou Z., Lenk R.P., Dellinger A. et al. Liposomal formulation of amphiphilic fullerene antioxidants. Bioconj Chem 2010;21:1656–61.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">20. Chaudhuri P., Paraskar A., Soni S. et al. Fullerenol-cytotoxic conjugates for cancer chemotherapy. ACS Nano 2009;3: 2505–14.</mixed-citation><mixed-citation xml:lang="ru">Chaudhuri P., Paraskar A., Soni S. et al. Fullerenol-cytotoxic conjugates for cancer chemotherapy. ACS Nano 2009;3: 2505–14.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">21. Song H., Luo S., Wei H. et al. In vivo biological behavior of 99mTc(CO)3 labelled fullerol. J Radioanal Nucl Chem 2010;285:635–9.</mixed-citation><mixed-citation xml:lang="ru">Song H., Luo S., Wei H. et al. In vivo biological behavior of 99mTc(CO)3 labelled fullerol. J Radioanal Nucl Chem 2010;285:635–9.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">22. Roberts J.E., Wielgus A.R., Boyes W.K. et al. Phototoxicity and cytotoxicity of fullerol in human lens epithelial cells. Toxicol Appl Pharmacol 2008;228: 49–58.</mixed-citation><mixed-citation xml:lang="ru">Roberts J.E., Wielgus A.R., Boyes W.K. et al. Phototoxicity and cytotoxicity of fullerol in human lens epithelial cells. Toxicol Appl Pharmacol 2008;228: 49–58.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">23. Zhao B., Yin J.J., Bilski P. et al. Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles. Toxicol Appl Pharmacol 2009;241:163–72.</mixed-citation><mixed-citation xml:lang="ru">Zhao B., Yin J.J., Bilski P. et al. Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles. Toxicol Appl Pharmacol 2009;241:163–72.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">24. Prow T.W., Bhutto I., Kim S.Y. et al. Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium. Nanomedicine 2008;4:340–9.</mixed-citation><mixed-citation xml:lang="ru">Prow T.W., Bhutto I., Kim S.Y. et al. Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium. Nanomedicine 2008;4:340–9.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">25. Bejjani R.A., Benezra D., Cohen H. et al. Nanoparticles for gene delivery to retinal pigment epithelial cells. Mol Vis 2005;17:124–32.</mixed-citation><mixed-citation xml:lang="ru">Bejjani R.A., Benezra D., Cohen H. et al. Nanoparticles for gene delivery to retinal pigment epithelial cells. Mol Vis 2005;17:124–32.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">26. Мешалкин Ю.П., Бгатова Н.Р. Перспективы и проблемы использования неорганических материалов в онкологии. Ж Сиб Фед Ун-та В 2008;3:248–68.</mixed-citation><mixed-citation xml:lang="ru">Мешалкин Ю.П., Бгатова Н.Р. Перспективы и проблемы использования неорганических материалов в онкологии. Ж Сиб Фед Ун-та В 2008;3:248–68.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">27. Mroz P., Tegos G.P., Gali H. et al. Photodynamic therapy with fullerenes. Photochem Photobiol Sci 2007;6:1139–49.</mixed-citation><mixed-citation xml:lang="ru">Mroz P., Tegos G.P., Gali H. et al. Photodynamic therapy with fullerenes. Photochem Photobiol Sci 2007;6:1139–49.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">28. Burlaka A.P., Sidorik U.P., Pryl 2004;26:326–7.</mixed-citation><mixed-citation xml:lang="ru">Burlaka A.P., Sidorik U.P., Pryl 2004;26:326–7.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">29. Mroz P., Pawlak A., Satti M. Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism. Free Radical Biol Med 2007;43:711–9.</mixed-citation><mixed-citation xml:lang="ru">Mroz P., Pawlak A., Satti M. Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism. Free Radical Biol Med 2007;43:711–9.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">30. Yano S., Hirohara S., Obata M. et al. Current states and future views inphotodynamic therapy. J Photochem Photobiol C 2011;12:46–67.</mixed-citation><mixed-citation xml:lang="ru">Yano S., Hirohara S., Obata M. et al. Current states and future views inphotodynamic therapy. J Photochem Photobiol C 2011;12:46–67.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">31. Hu Z., Zhang C., Huang Y. et al. Photodynamic anticancer activities of water-soluble C60 derivatives nd their biological consequences in a HeLa cell line. Chem Biol Inter 2012;195:86–94.</mixed-citation><mixed-citation xml:lang="ru">Hu Z., Zhang C., Huang Y. et al. Photodynamic anticancer activities of water-soluble C60 derivatives nd their biological consequences in a HeLa cell line. Chem Biol Inter 2012;195:86–94.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">32. Liu J., Ohta S., Sonoda A. Preparation of PEG-conjugated fullerene containing Gd3+ ions for photodynamic therapy. J Controlled Release 2007;117:104–10.</mixed-citation><mixed-citation xml:lang="ru">Liu J., Ohta S., Sonoda A. Preparation of PEG-conjugated fullerene containing Gd3+ ions for photodynamic therapy. J Controlled Release 2007;117:104–10.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">33. Jiang G., Li G. Preparation, characterization, and properties of fullerene–vinylpyrrolidone copolymers. Biotechnol Prog 2012;28:215–22.</mixed-citation><mixed-citation xml:lang="ru">Jiang G., Li G. Preparation, characterization, and properties of fullerene–vinylpyrrolidone copolymers. Biotechnol Prog 2012;28:215–22.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">34. Vileno B., Jeney S., Sienkiewicz A. et al. Evidence of lipid peroxidation and protein phosphorylation in cells upon oxidative stress photo-generated by fullerols. Biophys Chem 2010;152:164–9.</mixed-citation><mixed-citation xml:lang="ru">Vileno B., Jeney S., Sienkiewicz A. et al. Evidence of lipid peroxidation and protein phosphorylation in cells upon oxidative stress photo-generated by fullerols. Biophys Chem 2010;152:164–9.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">35. Badireddy A.R., Hotze E.M., Chellam S. et al. Inactivation of bacteriophages via photosensitization of fullerol nanoparticles. Environ Sci Technol 2007;41:6627–32.</mixed-citation><mixed-citation xml:lang="ru">Badireddy A.R., Hotze E.M., Chellam S. et al. Inactivation of bacteriophages via photosensitization of fullerol nanoparticles. Environ Sci Technol 2007;41:6627–32.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">36. Taroni P., D’Andrea C., Valentini G. et al. Fullerol in human lens and retinal pigment epithelial cells: time domain fluorescence spectroscopy and imaging. Photochem Photobiol Sci 2011;10:904–10.</mixed-citation><mixed-citation xml:lang="ru">Taroni P., D’Andrea C., Valentini G. et al. Fullerol in human lens and retinal pigment epithelial cells: time domain fluorescence spectroscopy and imaging. Photochem Photobiol Sci 2011;10:904–10.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">37. Straface E., Santini M.T., Donelli G. et al. Vitamin E prevents UVB-induced cell blebbing and cell death in A431 epidermoid cells. Int J Rad Biol 1995;68:579–87.</mixed-citation><mixed-citation xml:lang="ru">Straface E., Santini M.T., Donelli G. et al. Vitamin E prevents UVB-induced cell blebbing and cell death in A431 epidermoid cells. Int J Rad Biol 1995;68:579–87.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">38. Ito S., Itoga K., Yamato M. et al. The co-application effects of fullerene and ascorbic acid on UV-B irradiated mouse skin. Toxicology 2010;267:27–38.</mixed-citation><mixed-citation xml:lang="ru">Ito S., Itoga K., Yamato M. et al. The co-application effects of fullerene and ascorbic acid on UV-B irradiated mouse skin. Toxicology 2010;267:27–38.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">39. Fumelli C., Marconi A., Salvioli S. et al. Carboxyfullerenes protect human keratinocytes from ultraviolet-B-induced apoptosis. J Invest Dermatol 2000;115: 835–41.</mixed-citation><mixed-citation xml:lang="ru">Fumelli C., Marconi A., Salvioli S. et al. Carboxyfullerenes protect human keratinocytes from ultraviolet-B-induced apoptosis. J Invest Dermatol 2000;115: 835–41.</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">40. Zhao B., He Y.Y., Chignell C.F. et al. Difference in phototoxicity of cyclodextrin complexed fullerene [(γ-CyD)2/C60] and its aggregated derivatives toward human lens epithelial cells. Chem Res Toxicol 2009;22:660–7.</mixed-citation><mixed-citation xml:lang="ru">Zhao B., He Y.Y., Chignell C.F. et al. Difference in phototoxicity of cyclodextrin complexed fullerene [(γ-CyD)2/C60] and its aggregated derivatives toward human lens epithelial cells. Chem Res Toxicol 2009;22:660–7.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">41. Mikata Y., Takagi S., Tanahashi M. et al. Detection of 1270 nm emission from singlet oxygen and photocytotoxic property of sugar-pendant 60 fullerenes. Bioorg Med Chem Lett 2003;13:3289–92.</mixed-citation><mixed-citation xml:lang="ru">Mikata Y., Takagi S., Tanahashi M. et al. Detection of 1270 nm emission from singlet oxygen and photocytotoxic property of sugar-pendant 60 fullerenes. Bioorg Med Chem Lett 2003;13:3289–92.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">42. Otake E., Sakuma S., Torii K. et al. Effect and mechanism of a new photodynamic therapy with glycoconjugated fullerene. Photochem Photobiol 2010;86:1356–63.</mixed-citation><mixed-citation xml:lang="ru">Otake E., Sakuma S., Torii K. et al. Effect and mechanism of a new photodynamic therapy with glycoconjugated fullerene. Photochem Photobiol 2010;86:1356–63.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">43. Palyvoda K.O., Grynyuk I.I., Prylutsk S.V. et al. Apoptosis photoinduction by C60 fullerene in human leukemic T cells. Ukr Biochem J 2010;82:121–7.</mixed-citation><mixed-citation xml:lang="ru">Palyvoda K.O., Grynyuk I.I., Prylutsk S.V. et al. Apoptosis photoinduction by C60 fullerene in human leukemic T cells. Ukr Biochem J 2010;82:121–7.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">44. Constantin C., Neagu M., Ion R. et al. Fullerene-porphyrin nanostructures in photodynamic therapy. Nanomedicine 2010;5:307–17.</mixed-citation><mixed-citation xml:lang="ru">Constantin C., Neagu M., Ion R. et al. Fullerene-porphyrin nanostructures in photodynamic therapy. Nanomedicine 2010;5:307–17.</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">45. Sharma S.K., Chiang L.Y., Hamblin M.R. Photodynamic therapy with fullerenes in vivo: reality or a dream? Nanomedicine 2011;6:1813–25.</mixed-citation><mixed-citation xml:lang="ru">Sharma S.K., Chiang L.Y., Hamblin M.R. Photodynamic therapy with fullerenes in vivo: reality or a dream? Nanomedicine 2011;6:1813–25.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">46. Ni J., Wu Q.Y., Li Y.G. et al. Cytotoxic and radiosensitizing effects of nano-C60 on tumor cells in vitro. J Nanoparticle Res 2008;10:643–51.</mixed-citation><mixed-citation xml:lang="ru">Ni J., Wu Q.Y., Li Y.G. et al. Cytotoxic and radiosensitizing effects of nano-C60 on tumor cells in vitro. J Nanoparticle Res 2008;10:643–51.</mixed-citation></citation-alternatives></ref><ref id="B49"><label>49.</label><citation-alternatives><mixed-citation xml:lang="en">47. Andrievsky G., Bruskov V.I., Tykhomyrov A.A., Gudkov S.V. Peculiarities of the antioxidant and radioprotective effects of hydrated C60 fullerene nanostuctures in vitro and in vivo. Free Radic Biol Med 2009;47:786–93.</mixed-citation><mixed-citation xml:lang="ru">Andrievsky G., Bruskov V.I., Tykhomyrov A.A., Gudkov S.V. Peculiarities of the antioxidant and radioprotective effects of hydrated C60 fullerene nanostuctures in vitro and in vivo. Free Radic Biol Med 2009;47:786–93.</mixed-citation></citation-alternatives></ref><ref id="B50"><label>50.</label><citation-alternatives><mixed-citation xml:lang="en">48. Huang S.Q., Gao Y., Li F. et al. Synthesis of fullerene derivative C(60)-Lys and its radioprotection effects in AHH-1 cell. J Rad Res Rad Proces 2010;1:37–41.</mixed-citation><mixed-citation xml:lang="ru">Huang S.Q., Gao Y., Li F. et al. Synthesis of fullerene derivative C(60)-Lys and its radioprotection effects in AHH-1 cell. J Rad Res Rad Proces 2010;1:37–41.</mixed-citation></citation-alternatives></ref><ref id="B51"><label>51.</label><citation-alternatives><mixed-citation xml:lang="en">49. Theriot A.C., Casey R.C., Moore V.C. et al. Dendro[C60]fullerene DF-1 provides radioprotection to radiosensitive mammalian cells. Rad Envir Biophys 2010;49:437–45.</mixed-citation><mixed-citation xml:lang="ru">Theriot A.C., Casey R.C., Moore V.C. et al. Dendro[C60]fullerene DF-1 provides radioprotection to radiosensitive mammalian cells. Rad Envir Biophys 2010;49:437–45.</mixed-citation></citation-alternatives></ref><ref id="B52"><label>52.</label><citation-alternatives><mixed-citation xml:lang="en">50. Chirico F., Fumelli C., Marconi A. et al. Carboxyfullerenes localize within mitochondria and prevent the UVB-induced intrinsic apoptotic pathway. Exp Dermatol 2007;16:429–36.</mixed-citation><mixed-citation xml:lang="ru">Chirico F., Fumelli C., Marconi A. et al. Carboxyfullerenes localize within mitochondria and prevent the UVB-induced intrinsic apoptotic pathway. Exp Dermatol 2007;16:429–36.</mixed-citation></citation-alternatives></ref><ref id="B53"><label>53.</label><citation-alternatives><mixed-citation xml:lang="en">51. Dobrovolskaia M.A., McNeil S.E. Immunological properties of engineered nanomaterials. Nat Nanotechnol 2007;2:469–78.</mixed-citation><mixed-citation xml:lang="ru">Dobrovolskaia M.A., McNeil S.E. Immunological properties of engineered nanomaterials. Nat Nanotechnol 2007;2:469–78.</mixed-citation></citation-alternatives></ref><ref id="B54"><label>54.</label><citation-alternatives><mixed-citation xml:lang="en">52. Cai X., Hao J., Zhang X. et al. The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizingradiation- induced immune and mitochondrial dysfunction. Toxicol Appl Pharmacol 2010;243:27–34.</mixed-citation><mixed-citation xml:lang="ru">Cai X., Hao J., Zhang X. et al. The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizingradiation- induced immune and mitochondrial dysfunction. Toxicol Appl Pharmacol 2010;243:27–34.</mixed-citation></citation-alternatives></ref><ref id="B55"><label>55.</label><citation-alternatives><mixed-citation xml:lang="en">53. Injac R., Perse M., Cerne M. et al. Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer. Biomaterials 2009;30:1184–96.</mixed-citation><mixed-citation xml:lang="ru">Injac R., Perse M., Cerne M. et al. Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer. Biomaterials 2009;30:1184–96.</mixed-citation></citation-alternatives></ref><ref id="B56"><label>56.</label><citation-alternatives><mixed-citation xml:lang="en">54. Dordević A., Bogdanović G. Fullerenol – a new nanopharmaceutic? Arch Oncol 2008;16:42–5.</mixed-citation><mixed-citation xml:lang="ru">Dordević A., Bogdanović G. Fullerenol – a new nanopharmaceutic? Arch Oncol 2008;16:42–5.</mixed-citation></citation-alternatives></ref><ref id="B57"><label>57.</label><citation-alternatives><mixed-citation xml:lang="en">55. Takada H., Kokubo K., Matsubayashi K., O evaluated by β-carotene bleaching assay. Biosci Biotechnol Biochem 2006;70: 3088–93.</mixed-citation><mixed-citation xml:lang="ru">Takada H., Kokubo K., Matsubayashi K., O evaluated by β-carotene bleaching assay. Biosci Biotechnol Biochem 2006;70: 3088–93.</mixed-citation></citation-alternatives></ref><ref id="B58"><label>58.</label><citation-alternatives><mixed-citation xml:lang="en">56. Vávrová J., Řezáčová M., Pejchal J. Fullerene nanoparticles and their antioxidative effects: a comparison to other radioprotective agents. J Appl Biomed 2012;10:1–8.</mixed-citation><mixed-citation xml:lang="ru">Vávrová J., Řezáčová M., Pejchal J. Fullerene nanoparticles and their antioxidative effects: a comparison to other radioprotective agents. J Appl Biomed 2012;10:1–8.</mixed-citation></citation-alternatives></ref><ref id="B59"><label>59.</label><citation-alternatives><mixed-citation xml:lang="en">57. Fourches D., Pu D., Tassa C. et al. Quantitative nanostructure-activity relationship modeling. Acs Nano 2010;4:5703–12.</mixed-citation><mixed-citation xml:lang="ru">Fourches D., Pu D., Tassa C. et al. Quantitative nanostructure-activity relationship modeling. Acs Nano 2010;4:5703–12.</mixed-citation></citation-alternatives></ref><ref id="B60"><label>60.</label><citation-alternatives><mixed-citation xml:lang="en">58. Kayat J., Gajbhiye V., Tekade R.K., Jain N.K. Pulmonary toxicity of carbon nanotubes: a systematic report. Nanomed Nanotechnol Biol Med 2011;7:40–9.</mixed-citation><mixed-citation xml:lang="ru">Kayat J., Gajbhiye V., Tekade R.K., Jain N.K. Pulmonary toxicity of carbon nanotubes: a systematic report. Nanomed Nanotechnol Biol Med 2011;7:40–9.</mixed-citation></citation-alternatives></ref><ref id="B61"><label>61.</label><citation-alternatives><mixed-citation xml:lang="en">59. Miller J., Lam M., Lebovitz R. Derivatized fullerenes: a new class of therapeutics and imaging agents. HeinOnline. Nanotech. L. &amp; Bus., 2007.</mixed-citation><mixed-citation xml:lang="ru">Miller J., Lam M., Lebovitz R. Derivatized fullerenes: a new class of therapeutics and imaging agents. HeinOnline. Nanotech. L. &amp; Bus., 2007.</mixed-citation></citation-alternatives></ref><ref id="B62"><label>62.</label><citation-alternatives><mixed-citation xml:lang="en">60. Kepley C. Use of fullerenes for the treatment of mast cell and basophil-mediated disease. US Patent, № 7947262, 2006.</mixed-citation><mixed-citation xml:lang="ru">Kepley C. Use of fullerenes for the treatment of mast cell and basophil-mediated disease. US Patent, № 7947262, 2006.</mixed-citation></citation-alternatives></ref><ref id="B63"><label>63.</label><citation-alternatives><mixed-citation xml:lang="en">61. Kateb B., Chiu K., Black K.L. et al. Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy?NeuroImage, 2011;54:106–24.</mixed-citation><mixed-citation xml:lang="ru">Kateb B., Chiu K., Black K.L. et al. Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy?NeuroImage, 2011;54:106–24.</mixed-citation></citation-alternatives></ref><ref id="B64"><label>64.</label><citation-alternatives><mixed-citation xml:lang="en">62. Bystrzejewska-Piotrowska G., Golimowski J., Urban P.L. Nanoparticles: Their potential toxicity, waste and environmental management. Waste Management 2009;29:2587–95.</mixed-citation><mixed-citation xml:lang="ru">Bystrzejewska-Piotrowska G., Golimowski J., Urban P.L. Nanoparticles: Their potential toxicity, waste and environmental management. Waste Management 2009;29:2587–95.</mixed-citation></citation-alternatives></ref><ref id="B65"><label>65.</label><citation-alternatives><mixed-citation xml:lang="en">63. Lewinski N., Colvin V., Drezek R. Cytotoxicity of nanoparticles. Small 2008;4:26–49.</mixed-citation><mixed-citation xml:lang="ru">Lewinski N., Colvin V., Drezek R. Cytotoxicity of nanoparticles. Small 2008;4:26–49.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
