OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press33010.17650/1818-8346-2019-14-1-8-13HEMATOLOGIC MALIGNANCIES: TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯEfficiency of pomalidomide therapy in patients with multiple myeloma refractory to lenalidomideЭффективность помалидомидсодержащих программ у больных множественной миеломой при рефрактерности к леналидомидуhttps://orcid.org/0000-0001-5440-4340RekhtinaI. G.РехтинаИ. Г.
Russian Federation
rekhtina.i@blood.ruhttps://orcid.org/0000-0002-4966-8146MendeleevaL. P.МенделееваЛ. П.
Russian Federation
National Research Center for Hematology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России4 Novyy Zykovskiy Proezd, Moscow 125167Россия, 125167 Москва, Новый Зыковский проезд, 4100420191418131004201910042019https://oncohematology.abvpress.ru/ongm/article/view/330

Currently, there has been a marked increase in the number of opportunities for relapsed and refractory multiple myeloma treatment due to emergence of new target drugs. These include pomalidomide, a 3 rd generation immunomodulator capable of treating double refractory multiple myeloma (to lenalidomide and bortezomib). Efficacy and safety of pomalidomide combined with low doses of dexamethasone have been established in MM-003 and STRATUS trials. The summary presents the data on opportunities to further enhance the efficacy of pomalidomide combined with other antitumor drugs in patients with relapsed and refractory multiple myeloma who previously received 4–5 lines of therapy. It has been shown that triplets based on pomalidomide and dexamethasone combined with cyclophosphamide, bendamustine, daratumumab, carfilzomib, elotuzumab are highly effective in double refractory multiple myeloma patients. A combination of pomalidomide with proteasome inhibitors is a promising treatment provided that there is no refractoriness to bortezomib.

В настоящее время существенно расширились возможности в лечении рефрактерной/рецидивирующей множественной миеломы ввиду появления новых препаратов таргетного действия, одним из которых является помалидомид. Помалидомид – иммуномодулирирующий препарат 3-го поколения, позволяющий преодолеть двойную рефрактерность (к леналидомиду и бортезомибу). Эффективность и безопасность помалидомида с низкими дозами дексаметазона подтверждены в исследованиях ММ-003 и STRATUS. В обзоре представлены данные о возможности повышения эффективности лечения при комбинации помалидомида с другими противоопухолевыми препаратами у больных рефрактерной/рецидивирующей множественной миеломой, которые ранее получили 4–5 линий терапии. Показано, что триплеты на основе помалидомида и дексаметазона в сочетании с циклофосфамидом, бендамустином, даратумумабом, карфилзомибом, элотузумабом высокоэффективны у пациентов с двойной рефрактерностью. Комбинация помалидомида с ингибиторами протеасом является перспективным подходом при отсутствии рефрактерности к бортезомибу.

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